IEMN
  • Home
  • News
    • IEMN Newsletters
    • M2-Ingé Internships
    • Job offers
    • All news
  • The Institute
    • Presentation
    • Organization of the institute
    • The Scientific Department
    • The Technological Department
    • Administrative and financial management
    • Rules of procedure
    • Our commitments
  • The Research
    • Scientific departments
      • Nanostructured Materials and Components
      • Micro / nano optoelectronics
      • Telecommunications Technologies and Intelligent Systems
      • Acoustic
    • Research groups
    • Flagship
  • Scientific Production
    • IEMN publications
    • Scientific production resources
  • The platforms
    • CMNF - Central Platform for Micro Nano Manufacturing
      • Engraving and implantation pole
      • In Line Analysis Unit
      • Soft Lithography and Bio Microfluidics
      • Deposits and epitaxy division
      • Lithography Unit
      • Packaging Division
      • CMNF Staff
    • PCMP - Multi-Physics Characterization Platform
      • Scanning Probe Microscopy Facility
      • Hyperfrequency, Optical and Photonic Characterization (CHOP)
      • Advanced Communications Systems and Prototyping cluster (SigmaCOM)
      • Characterisation, ElectroMagnetic Compatibility and Prototyping Centre (C2EM)
      • PCMP Staff
    • Services offered by our platforms
  • Partnership - Valuation
    • Academic Collaborations
    • ANR Projects
    • Main international collaborations
    • Industrial partnerships
    • The joint IEMN-Industry laboratories
    • Startups
  • Research Training
    • After the thesis
      • Do a post-doc at the IEMN
      • Towards the world of business and industry
      • Become a teacher-researcher
      • Become a Researcher
      • Starting a business at IEMN
      • FOCUS on a SATT engineer from the IEMN
    • A thesis at IEMN
      • Thesis and HDR defenses
      • Thesis topics
      • Financing
      • Doctoral studies
    • Master - Engineer
      • Masters ULille
        • Master Life Sciences and Technologies graduate programme
        • Master Nanosciences and Nanotechnologies - Speciality ETECH
        • Master Networks and Telecommunications
      • UPHF-INSA Masters
        • Master in Embedded Systems and Mobile Communications Engineering
        • Master Cyber Defense and Information Security
        • Master in Materials, Control and Safety
        • Master in Image and Sound Systems Engineering
      • Partner/Tutoring Engineering Schools
      • M2-Ingé Internships
    • The Lille branch of the GIP-CNFM
    • Nano-École Lille
  • Contact Us
    • Location
    • Contact form
    • Annuaire Intranet
  • Our support
  • fr_FR
  • Rechercher
  • Menu Menu
GROUPE DE RECHERCHE : PHYSIQUE
GROUPE DE RECHERCHE : PHYSIQUE

LIMMS-UGSF-CANTHER-IEMN project

Researchers from Lille and Tokyo have joined forces to design specific sensors for proteins in the SARS-CoV-2 virus.
Simulations aim to elucidate the molecular mechanisms of recognition and interaction of these proteins.

The image shows the Spike protein (grey-cyan) interacting with the ACE2 human receptor (blue) and a candidate ssDNA aptamer (red) binding to the same receptor binding site.

In a project involving experimental and modelling teams at LIMMS (Tokyo), IEMN, UGSF and CANTHER CNRS units (Lille), we are using large-scale molecular simulations to design nanoscale quantum-dot sensors, aimed at recognising the 'spike' protein and the N-protein of the SARS-CoV-2 virus, by means of ssDNA aptamers. Very cheap to produce in large quantities, extremely biocompatible with practically no adverse effects, aptamers are capable of specifically binding to targets and modulating or blocking their activity, just like natural antibodies. Generated by an in-vitro selection process from pools of random sequence oligonucleotides (the SELEX technique), a typical aptamer is 10-30 kDa in size (about 30-60 DNA or RNA nucleotides), it binds its target with sub-nanomolar affinity, and can discriminate against closely related targets. Our molecular simulations elucidate the microscopic details of the DNA interaction with key proteins of the virus. Furthermore, in the framework of CoVid-19 innovative therapies, we are investigating the possibility that the same DNA aptamers could actively block, or at least slow down, the "opening" mechanism of the S-protein, thereby suppressing or strongly reducing the cell-receptor binding, which is the key lead to virus infection.

Contact: Fabrizio CLERI

.


This work is supported by the national supercomputing initiative GENCI.

Logo
Cité Scientifique
Avenue Henri Poincaré
CS 60069
59 652 Villeneuve d'Ascq Cedex, France
Tel : 03 20 19 79 79
CNRS Logo University of Lille Logo University Polytech Logo Junia Logo Centrale Lille Logo Renatech Logo RFnet Logo
Site map
Copyright Service ECM et pôle SISR 2024
  • Scientific production
  • Legal information
  • Privacy policy
Faire défiler vers le haut
fr_FR
fr_FR
en_GB
We use cookies to ensure you have the best experience on our website. If you continue to use this site, we will assume that you are happy with it.OKNoPrivacy policy