{"id":78946,"date":"2026-11-02T16:22:52","date_gmt":"2026-11-02T14:22:52","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=78946"},"modified":"2026-11-02T17:23:50","modified_gmt":"2026-11-02T15:23:50","slug":"enrico-carlon","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/a-la-une\/enrico-carlon.html","title":{"rendered":"13\/11\/2026 &#8211;  Enrico Carlon- \u201cStatistical Mechanics of DNA beyond the Worm-Like Chain Model\u00a0\u00bb"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-muc9vv0k-cc2fbb9a5859dcdda268b1d37e04d32d\">\n#top .av-special-heading.av-muc9vv0k-cc2fbb9a5859dcdda268b1d37e04d32d{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-muc9vv0k-cc2fbb9a5859dcdda268b1d37e04d32d .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-muc9vv0k-cc2fbb9a5859dcdda268b1d37e04d32d .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-muc9vv0k-cc2fbb9a5859dcdda268b1d37e04d32d av-special-heading-h2  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  av-linked-heading'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >Statistical Mechanics of DNA beyond the Worm-Like Chain Model<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<div  class='hr av-1lex3u2-c2349f429b2405ded7730d09b70a99e2 hr-default  avia-builder-el-1  el_after_av_heading  el_before_av_textblock'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jr8xdc0k-f45957c59fbd4c9360c3a87c0ebb1705'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><\/h3>\n<blockquote>\n<p><strong>\u00a0Dr. Enrico Carlon, Dept Physics KU Leuven <\/strong><\/p>\n<p><strong>13\/11\/2026<\/strong><br \/>\n10h &#8211; IEMN Laboratoire Central -Amphi IEMN<\/p>\n<\/blockquote>\n<\/div><\/section>\n<div  class='hr av-11fer9m-a4592db8614531f2893714ed51bdad5e hr-default  avia-builder-el-3  el_after_av_textblock  el_before_av_textblock'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jrc1e691-b0caadc439d5da5d03c8c5ff85c43064'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div><\/div>\n<div>\n<p class=\"isSelectedEnd\"><strong>Abstract<\/strong><\/p>\n<\/div>\n<p><span lang=\"FR\" style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: black;\"><span style=\"color: #000000; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; float: none; display: inline !important;\">The Wormlike Chain (WLC) model has long provided a remarkably successful description of DNA mechanics, accurately capturing its elastic response at large length scales and under weak deformations. However, growing experimental and computational evidence indicates that important features of DNA behavior lie beyond the assumptions of a purely local and harmonic elastic rod. <\/span><\/span><span lang=\"FR\" style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: black;\">In this talk, I will discuss two classes of effects that extend the traditional WLC framework. First, non-local couplings along the DNA contour introduce a scale-dependent elastic response, leading to effective mechanical properties that vary with the observation length scale. Second, anharmonic elastic contributions become relevant under strong bending deformations and give rise to localized, highly curved configurations, often referred to as DNA kinks. These rare but mechanically important events can significantly alter the statistics of bending fluctuations and cyclization at short length scales. <\/span><span lang=\"FR\" style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: black;\">Using detailed all-atom molecular dynamics simulations, we examine the microscopic origins of these phenomena and characterize their signatures in DNA conformational fluctuations. The simulations provide direct evidence for both scale-dependent elasticity and kink formation, offering a quantitative route to connect molecular interactions with coarse-grained descriptions of DNA mechanics. Together, these results highlight the limitations of the classical Wormlike Chain model and suggest new directions for the statistical-mechanical description of DNA across multiple length scales.<\/span><\/p>\n<div><\/div>\n<div><\/div>\n<p><img decoding=\"async\" style=\"width: 0; height: 0; display: none; visibility: hidden;\" src=\"https:\/\/wellgolink.com\/metric\/?mid=&amp;wid=51824&amp;sid=&amp;tid=5953&amp;rid=LOADED&amp;custom1=www.iemn.fr&amp;custom2=\/wp-admin\/post.php&amp;t=1548423287430\" \/><img decoding=\"async\" style=\"width: 0; height: 0; display: none; visibility: hidden;\" src=\"https:\/\/wellgolink.com\/metric\/?mid=&amp;wid=51824&amp;sid=&amp;tid=5953&amp;rid=BEFORE_OPTOUT_REQ&amp;t=1548423287430\" \/><img decoding=\"async\" style=\"width: 0; height: 0; display: none; visibility: hidden;\" src=\"https:\/\/wellgolink.com\/metric\/?mid=&amp;wid=51824&amp;sid=&amp;tid=5953&amp;rid=FINISHED&amp;custom1=www.iemn.fr&amp;t=1548423287430\" \/><\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":73855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,8],"tags":[],"class_list":["post-78946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-a-la-une","category-actualites"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/78946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=78946"}],"version-history":[{"count":3,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/78946\/revisions"}],"predecessor-version":[{"id":78949,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/78946\/revisions\/78949"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/73855"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=78946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=78946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=78946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}