{"id":76362,"date":"2025-12-10T17:07:07","date_gmt":"2025-12-10T15:07:07","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=76362"},"modified":"2025-12-15T10:44:33","modified_gmt":"2025-12-15T08:44:33","slug":"new-hope-in-the-fight-against-one-of-the-most-aggressive-paediatric-cancers-contre-lun-des-cancers-pediatriques-les-plus-agressifs-2","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/newsletter\/new-hope-in-the-fight-against-one-of-the-most-aggressive-paediatric-cancers-contre-lun-des-cancers-pediatriques-les-plus-agressifs-2.html","title":{"rendered":"New advance in the fight against one of the most aggressive paediatric cancers"},"content":{"rendered":"<div  class='flex_column av-2wo5xtj-fea3e9b7cfb64e774d7c6f7e6914db5c av_one_full  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  first flex_column_div'     ><section  class='av_textblock_section av-swmx9z-fa3e3cd9aca324bd791df9aba61dceb8'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2 style=\"text-align: center;\">New advance in the fight against one of the most aggressive paediatric cancers<\/h2>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2i9rtef-600472cd3cf2111b2d07a851baaa2b0e\">\n#top .hr.av-2i9rtef-600472cd3cf2111b2d07a851baaa2b0e{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-2i9rtef-600472cd3cf2111b2d07a851baaa2b0e .hr-inner{\nwidth:200;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-2i9rtef-600472cd3cf2111b2d07a851baaa2b0e hr-custom  avia-builder-el-2  el_after_av_one_full  el_before_av_three_fourth  hr-center hr-icon-yes'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue808' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-243lh4n-2e4572d8cfdaada1730945fe1a025e85\">\n@keyframes av_boxShadowEffect_av-243lh4n-2e4572d8cfdaada1730945fe1a025e85-column {\n0%   { box-shadow:  0 0 0 0 #dbdbdb; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #dbdbdb; opacity: 1; }\n}\n.flex_column.av-243lh4n-2e4572d8cfdaada1730945fe1a025e85{\nwidth:73.5%;\nbox-shadow: 0 0 10px 0 #dbdbdb;\nborder-radius:15px 15px 15px 15px;\npadding:40px 40px 40px 40px;\nbackground-color:#d8d8d8;\nbackground:linear-gradient( to top, #d8d8d8, #e5e5e5, #ffffff );\n}\n.flex_column.av-243lh4n-2e4572d8cfdaada1730945fe1a025e85 .avia-divider-svg-top{\nborder-radius:15px 15px 0 0;\n}\n.flex_column.av-243lh4n-2e4572d8cfdaada1730945fe1a025e85 .avia-divider-svg-top svg{\nheight:35px;\nwidth:calc(100% + 1.3px);\nfill:#ed9e17;\n}\n<\/style>\n<div  class='flex_column av-243lh4n-2e4572d8cfdaada1730945fe1a025e85 av_three_fourth  avia-builder-el-3  el_after_av_hr  el_before_av_one_fourth  first av-break-at-tablet flex_column_div av-animated-generic fade-in shadow-not-animated'     ><div class='avia-divider-svg avia-divider-svg-triangle avia-divider-svg-top avia-svg-original'><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path d=\"M500,98.9L0,6.1V0h1000v6.1L500,98.9z\"\/>\n<\/svg><\/div><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m0zakv6p-780a94cb8a8b06afee76298e29cd3b3c\">\n#top .av_textblock_section.av-m0zakv6p-780a94cb8a8b06afee76298e29cd3b3c .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-m0zakv6p-780a94cb8a8b06afee76298e29cd3b3c'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"introduction\" style=\"text-align: justify;\">\n<div class=\"clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item\">\n<div class=\"tex2jax_process\">\n<p><strong><span style=\"color: #333399;\">\u00a0<\/span><\/strong><\/p>\n<p><strong><span style=\"color: #008080;\"><span style=\"color: #ff7b0f;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-a271d0d206916d71f6272c97868fc8fa\">\n.av_font_icon.av-mqde7m-a271d0d206916d71f6272c97868fc8fa{\ncolor:#08080;\nborder-color:#08080;\n}\n.av_font_icon.av-mqde7m-a271d0d206916d71f6272c97868fc8fa .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-a271d0d206916d71f6272c97868fc8fa avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue885' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/span> <\/span><\/strong><\/p>\n<p><strong>Diffuse midline gliomas (DMG) are among the most aggressive and devastating paediatric brain tumours, with very rapid progression and a mortality rate of approximately 98% within one year of diagnosis.<\/strong> Located in deep and vital regions of the brain, they are almost impossible to remove surgically, and radiotherapy, which offers only temporary relief, remains the only standard treatment more than fifty years after its introduction.<a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-76406\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-845x321.png\" alt=\"\" width=\"380\" height=\"224\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-300x177.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-1030x608.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-768x453.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-1536x907.png 1536w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-18x12.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-1500x886.png 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2-705x416.png 705w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/cancer2.png 1714w\" sizes=\"auto, (max-width: 380px) 100vw, 380px\" \/><\/a><\/p>\n<p>Over the past decade, new discoveries about the genetic [1] and epigenetic [2] factors of GMD have raised hopes for new therapies. Scientists have identified specific mutations in histone genes [3] that profoundly alter the way tumour cells regulate their DNA, suggesting that \u201cepi-drugs\u201d, which target these epigenetic changes, may be promising. In laboratory studies, several of these drugs have shown strong anti-tumour effects. However, in clinical trials, they have failed to improve patient survival.<\/p>\n<p>Why is there such a discrepancy? One of the main reasons lies in how we test therapies before they reach patients. Most preclinical models<a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftn4\"> [4]<\/a> rely on cancer cells grown in 2D on plastic surfaces, under conditions that are very different from the complex environment of a real tumour. Inside the brain, tumour cells live in a dense, three-dimensional matrix of proteins, surrounded by gradients of oxygen [5] and nutrients. These physical and chemical constraints strongly influence their growth, stress resistance and response to treatment.<\/p>\n<hr \/>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\"><\/a><\/p>\n<div id=\"attachment_76307\" style=\"width: 918px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-76307\" class=\"wp-image-76307 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1.png\" alt=\"\" width=\"908\" height=\"304\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1.png 908w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1-300x100.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1-768x257.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1-18x6.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/12\/dmg-1-705x236.png 705w\" sizes=\"auto, (max-width: 908px) 100vw, 908px\" \/><\/a><p id=\"caption-attachment-76307\" class=\"wp-caption-text\">Schematic representation of the DMG-on-Chip<\/p><\/div>\n<hr \/>\n<p>To fill this gap, as part of a highly interdisciplinary project led by Dr Furlan and Dr Meignan from the OncoLille Institute and the Oscar-Lambret Centre in collaboration with the IEMN and funded by the INCA, a new \u2018DMG-on-Chip\u2019 model \u00a0\u00bb \u2013 a miniature, transparent device that recreates the essential characteristics of the tumour&rsquo;s natural habitat.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"section-elements\" style=\"text-align: left;\">\n<div id=\"person-1008\" class=\"field__item vcard node node--type-personne node--view-mode-block\"><\/div>\n<\/div>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-5j0kjb-82cbccc7707a49d97d26a38e3c8032fa\">\n@keyframes av_boxShadowEffect_av-5j0kjb-82cbccc7707a49d97d26a38e3c8032fa-column {\n0%   { box-shadow:  0 0 0 0 #cecece; opacity: 1; }\n100% { box-shadow:  0 0 20px 0 #cecece; opacity: 1; }\n}\n.flex_column.av-5j0kjb-82cbccc7707a49d97d26a38e3c8032fa{\nwidth:20.5%;\nmargin-left:6%;\nbox-shadow: 0 0 20px 0 #cecece;\nborder-radius:20px 20px 20px 20px;\npadding:10px 10px 10px 10px;\nbackground-color:#f2f2f2;\nbackground:linear-gradient( to top, #f2f2f2, #edd4aa, #ffffff );\n}\n.flex_column.av-5j0kjb-82cbccc7707a49d97d26a38e3c8032fa .avia-divider-svg-top{\nborder-radius:20px 20px 0 0;\n}\n.flex_column.av-5j0kjb-82cbccc7707a49d97d26a38e3c8032fa .avia-divider-svg-top svg{\nheight:25px;\nwidth:calc(100% + 1.3px);\nfill:#cccccc;\n}\n<\/style>\n<div  class='flex_column av-5j0kjb-82cbccc7707a49d97d26a38e3c8032fa av_one_fourth  avia-builder-el-6  el_after_av_three_fourth  el_before_av_one_third  av-break-at-tablet flex_column_div shadow-not-animated'     ><div class='avia-divider-svg avia-divider-svg-triangle avia-divider-svg-top avia-svg-original'><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path d=\"M500,98.9L0,6.1V0h1000v6.1L500,98.9z\"\/>\n<\/svg><\/div><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6jduhqy-14f796ec1c2242936a1642046da33530\">\n#top .hr.hr-invisible.av-m6jduhqy-14f796ec1c2242936a1642046da33530{\nheight:50px;\n}\n<\/style>\n<div  class='hr av-m6jduhqy-14f796ec1c2242936a1642046da33530 hr-invisible  avia-builder-el-7  el_before_av_textblock  avia-builder-el-first'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-10w0uzb-60de89e9989bb5799194996ef970595b\">\n#top .av_textblock_section.av-10w0uzb-60de89e9989bb5799194996ef970595b .avia_textblock{\nfont-size:12px;\ntext-align:left;\n}\n<\/style>\n<section  class='av_textblock_section av-10w0uzb-60de89e9989bb5799194996ef970595b'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h5><b><u>Caption<\/u><\/b>:<\/h5>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftnref1\"><i>[1]<\/i><\/a><i> Most cancers are caused by changes in genes that usually occur randomly and are not necessarily hereditary. They are acquired at some point in a person&rsquo;s life. These genetic changes are called sporadic (spontaneous) or acquired mutations.<\/i><\/p>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftnref2\"><i>[2]<\/i><\/a><em> Epigenetics is the study of the biochemical mechanisms that regulate gene expression without altering the DNA sequence. In fact, it is not always the sequence that matters, but how it is used. The link between epigenetics and cancer stems from epigenetic dysregulation (histone acetylation, DNA methylation, etc.) which, for example, can inactivate tumour suppressor genes that are naturally present in the genome.<\/em><\/p>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftnref3\"><i>[3]<\/i><\/a><em> DNA-binding proteins in the cell nucleus. Each strand of DNA, approximately 50 nanometres long, is typically wound into small \u2018beads\u2019 around a block of eight histones, resulting in a \u2018string of beads\u2019 structure called chromatin, which forms the basis of the structural organisation of chromosomes. This dense organisation allows the entire length of human DNA, approximately 1.5 metres when uncoiled, to be compacted into the cell nucleus, a spheroid with a diameter of approximately 10 micrometres.<\/em><\/p>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftnref4\"><i>[4]<\/i><\/a><em> A cancer model is an artificially induced or natural system that shares characteristics with human malignant tumours, for example isolated cells or laboratory animals. Preclinical studies aim to determine the potential efficacy of a drug, procedure or treatment and must be carried out before any human trials (regulated in France by Law 2012-300 of 5 March 2012 on research involving human subjects, and subsequent amendments).<\/em><\/p>\n<hr \/>\n<div class=\"section-elements\">\n<div id=\"person-1823\" class=\"field__item vcard node node--type-personne node--view-mode-block\">\n<div class=\"section-elements\">\n<div id=\"person-1008\" class=\"field__item vcard node node--type-personne node--view-mode-block\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/section><\/p><\/div><\/p>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-22r2s1c-955bef19e5cd92185f78469a2ec2c7ad\">\n@keyframes av_boxShadowEffect_av-22r2s1c-955bef19e5cd92185f78469a2ec2c7ad-column {\n0%   { box-shadow:  0 0 0 0 #dbdbdb; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #dbdbdb; opacity: 1; }\n}\n#top .flex_column.av-22r2s1c-955bef19e5cd92185f78469a2ec2c7ad{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n.flex_column.av-22r2s1c-955bef19e5cd92185f78469a2ec2c7ad{\nwidth:30%;\nbox-shadow: 0 0 10px 0 #dbdbdb;\nborder-radius:10px 10px 10px 10px;\npadding:40px 40px 40px 40px;\nbackground-color:#d8d8d8;\nbackground:linear-gradient( to top, #d8d8d8, #e5e5e5, #ffffff );\n}\n.responsive #top #wrap_all .flex_column.av-22r2s1c-955bef19e5cd92185f78469a2ec2c7ad{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n<\/style>\n<div  class='flex_column av-22r2s1c-955bef19e5cd92185f78469a2ec2c7ad av_one_third  avia-builder-el-9  el_after_av_one_fourth  el_before_av_one_third  first av-break-at-tablet flex_column_div av-animated-generic fade-in shadow-not-animated  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mizrvb26-cdffd81f07cfe14feb3a2023b8733082\">\n#top .av_textblock_section.av-mizrvb26-cdffd81f07cfe14feb3a2023b8733082 .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-mizrvb26-cdffd81f07cfe14feb3a2023b8733082'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"introduction\" style=\"text-align: justify;\">\n<div class=\"clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item\">\n<div class=\"tex2jax_process\">\n<p><strong><span style=\"color: #333399;\">\u00a0<\/span><\/strong><\/p>\n<hr \/>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\"><\/a><\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\"><\/a><\/p>\n<p><strong><span style=\"color: #008080;\"><span style=\"color: #ff7b0f;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1tytbhs-32d275ab1fa084652c7a36ba34d6eb97\">\n.av_font_icon.av-1tytbhs-32d275ab1fa084652c7a36ba34d6eb97{\ncolor:#08080;\nborder-color:#08080;\n}\n.av_font_icon.av-1tytbhs-32d275ab1fa084652c7a36ba34d6eb97 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-1tytbhs-32d275ab1fa084652c7a36ba34d6eb97 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue885' data-av_iconfont='entypo-fontello' ><\/span><\/span> <\/span><\/span><\/strong><\/p>\n<p>To address this gap, a new \u2018DMG-on-Chip\u2019 model \u2013 a miniature, transparent device that recreates the essential characteristics of the tumour&rsquo;s natural habitat \u2013 has been developed. In this microfluidic chip, <a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftn1\">[6]<\/a> a 3D tumour is embedded in a gel containing key components of the brain&rsquo;s extracellular matrix, such as collagen, laminin and hyaluronic acid. Oxygen is supplied only at the edges, creating a gradient similar to what occurs inside real tumours: well-oxygenated cells at the periphery and stressed, oxygen-deprived cells at the centre.<\/p>\n<p>Unlike conventional \u2018passive\u2019 cell cultures, this configuration allows scientists to monitor in real time how tumour cells behave under these realistic conditions, and to continuously modify and adjust the experimental conditions. As oxygen levels drop, brain cells slow down their division, rewire their metabolism and activate genetic programmes that help them survive. Using advanced imaging and transcriptomic analyses<a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftn1\"> [7]<\/a>, the researchers mapped these changes on the chip and discovered the molecular signatures of stress and resistance that occur when brain cells are hypoxic.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"section-elements\" style=\"text-align: left;\">\n<div id=\"person-1008\" class=\"field__item vcard node node--type-personne node--view-mode-block\"><\/div>\n<\/div>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-18jqtxs-7ef9e576bd94214b50ff9e65efbb9340\">\n@keyframes av_boxShadowEffect_av-18jqtxs-7ef9e576bd94214b50ff9e65efbb9340-column {\n0%   { box-shadow:  0 0 0 0 #dbdbdb; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #dbdbdb; opacity: 1; }\n}\n#top .flex_column.av-18jqtxs-7ef9e576bd94214b50ff9e65efbb9340{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n.flex_column.av-18jqtxs-7ef9e576bd94214b50ff9e65efbb9340{\nwidth:30%;\nmargin-left:5%;\nbox-shadow: 0 0 10px 0 #dbdbdb;\nborder-radius:15px 15px 15px 15px;\npadding:40px 40px 40px 40px;\nbackground-color:#d8d8d8;\nbackground:linear-gradient( to top, #d8d8d8, #e5e5e5, #ffffff );\n}\n.responsive #top #wrap_all .flex_column.av-18jqtxs-7ef9e576bd94214b50ff9e65efbb9340{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n<\/style>\n<div  class='flex_column av-18jqtxs-7ef9e576bd94214b50ff9e65efbb9340 av_one_third  avia-builder-el-12  el_after_av_one_third  el_before_av_one_third  av-break-at-tablet flex_column_div av-animated-generic fade-in shadow-not-animated  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mj03akr8-a65f90a3d5afad7b3dc45becc4d017fc\">\n#top .av_textblock_section.av-mj03akr8-a65f90a3d5afad7b3dc45becc4d017fc .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-mj03akr8-a65f90a3d5afad7b3dc45becc4d017fc'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"introduction\" style=\"text-align: justify;\">\n<div class=\"clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item\">\n<div class=\"tex2jax_process\">\n<p><strong><span style=\"color: #333399;\">\u00a0<\/span><\/strong><\/p>\n<hr \/>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\"><\/a><\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\"><\/a><\/p>\n<p><strong><span style=\"color: #008080;\"><span style=\"color: #ff7b0f;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kkvawg-9825ff3585bab169f5c25c6e4690312c\">\n.av_font_icon.av-kkvawg-9825ff3585bab169f5c25c6e4690312c{\ncolor:#08080;\nborder-color:#08080;\n}\n.av_font_icon.av-kkvawg-9825ff3585bab169f5c25c6e4690312c .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-kkvawg-9825ff3585bab169f5c25c6e4690312c avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue885' data-av_iconfont='entypo-fontello' ><\/span><\/span> <\/span><\/span><\/strong><\/p>\n<p>The platform also allows for more precise testing of the effects of therapies. By analysing how different regions of the chip respond to drugs or radiation, we were able to reveal striking spatial heterogeneity: while some cells die, others \u2013 protected by their microenvironment \u2013 survive and continue to grow. Such trends seem to reflect what clinicians have observed in patients and may help explain why some treatments fail, even when they appear effective in standard laboratory tests.<\/p>\n<p>The immediate application to DMG, the DMG-on-Chip approach developed with the IEMN, represents a transformative shift in cancer research: moving towards more realistic and interdisciplinary models that integrate biology, physics and engineering, as well as mathematical modelling.<\/p>\n<p>By faithfully reproducing the biophysical conditions of a tumour, this model could accelerate the arrival of more effective treatments for these children, who currently have virtually no therapeutic options. More than just a scientific tool, DMG-on-Chip could well become an indispensable link between the laboratory and the patient&rsquo;s bedside, helping to transform one of the most tragic childhood diseases into a field of hope and progress.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"section-elements\" style=\"text-align: left;\">\n<div id=\"person-1008\" class=\"field__item vcard node node--type-personne node--view-mode-block\"><\/div>\n<\/div>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-z6l228-5f681d319ed27482e34e69879227fc18\">\n@keyframes av_boxShadowEffect_av-z6l228-5f681d319ed27482e34e69879227fc18-column {\n0%   { box-shadow:  0 0 0 0 #cecece; opacity: 1; }\n100% { box-shadow:  0 0 20px 0 #cecece; opacity: 1; }\n}\n#top .flex_column.av-z6l228-5f681d319ed27482e34e69879227fc18{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n.flex_column.av-z6l228-5f681d319ed27482e34e69879227fc18{\nwidth:30%;\nmargin-left:5%;\nbox-shadow: 0 0 20px 0 #cecece;\nborder-radius:20px 20px 20px 20px;\npadding:15px 15px 15px 15px;\nbackground-color:#f2f2f2;\nbackground:linear-gradient( to top, #f2f2f2, #edd4aa, #ffffff );\n}\n.flex_column.av-z6l228-5f681d319ed27482e34e69879227fc18 .avia-divider-svg-top{\nborder-radius:20px 20px 0 0;\n}\n.flex_column.av-z6l228-5f681d319ed27482e34e69879227fc18 .avia-divider-svg-top svg{\nheight:25px;\nwidth:calc(100% + 1.3px);\nfill:#cccccc;\n}\n.responsive #top #wrap_all .flex_column.av-z6l228-5f681d319ed27482e34e69879227fc18{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n<\/style>\n<div  class='flex_column av-z6l228-5f681d319ed27482e34e69879227fc18 av_one_third  avia-builder-el-15  el_after_av_one_third  el_before_av_two_third  av-break-at-tablet flex_column_div shadow-not-animated  column-top-margin'     ><div class='avia-divider-svg avia-divider-svg-triangle avia-divider-svg-top avia-svg-original'><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path d=\"M500,98.9L0,6.1V0h1000v6.1L500,98.9z\"\/>\n<\/svg><\/div><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-loa75c-1b120ef4f4f183a68ce2135e804d1502\">\n#top .hr.hr-invisible.av-loa75c-1b120ef4f4f183a68ce2135e804d1502{\nheight:50px;\n}\n<\/style>\n<div  class='hr av-loa75c-1b120ef4f4f183a68ce2135e804d1502 hr-invisible  avia-builder-el-16  el_before_av_textblock  avia-builder-el-first'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mizrvx1r-7cd6367c62288e4abca3f0e5f5babdd3\">\n#top .av_textblock_section.av-mizrvx1r-7cd6367c62288e4abca3f0e5f5babdd3 .avia_textblock{\nfont-size:12px;\ntext-align:left;\n}\n<\/style>\n<section  class='av_textblock_section av-mizrvx1r-7cd6367c62288e4abca3f0e5f5babdd3'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h5><b><u>Caption<\/u><\/b>:<\/h5>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftnref5\"><i>[5]<\/i><\/a><em> The word \u2018gradient\u2019 is the mathematical definition of the spatial variation of a measured quantity, in this case the variation (decrease) in oxygen concentration in tissues. Hypoxic brain injury is damage to certain parts of the brain resulting from insufficient oxygen supply to the affected area. The decrease in oxygen supply to tissues, called hypoxia, damages cells and can lead to their destruction.<\/em><\/p>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftn1\"><i>[6]<\/i><\/a><em> The term microfluidics encompasses all the sciences and techniques of systems that manipulate fluids in circuits manufactured by printing on transparent materials (allowing access and visualisation), at least one of whose characteristic dimensions is in the order of a micrometre. These devices can handle microscopic quantities of fluid (billionths of a litre) comparable to the size of cells.<\/em><\/p>\n<p><a href=\"https:\/\/www.deepl.com\/fr\/translator#_ftn1\"><i>[7]<\/i><\/a><em> Transcriptomics is a sub-discipline of genomics devoted to the study of the transcriptome, i.e. all the RNA molecules (transcripts) resulting from the transcription of DNA comprising the entire genome of an organism. Transcriptomics emerged with the advent of high-throughput analysis techniques such as DNA microarrays and, more recently, high-capacity DNA sequencers. Comparing transcriptomes makes it possible to identify genes that are differentially expressed between distinct cell populations or in response to different treatments.<\/em><\/p>\n<hr \/>\n<div class=\"section-elements\">\n<div id=\"person-1823\" class=\"field__item vcard node node--type-personne node--view-mode-block\">\n<div class=\"section-elements\">\n<div id=\"person-1008\" class=\"field__item vcard node node--type-personne node--view-mode-block\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/section><\/p><\/div>\n<div  class='flex_column av-pnadxz-79a5356e461c81b91c276ec92ec199b6 av_two_third  avia-builder-el-18  el_after_av_one_third  avia-builder-el-last  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-m0w1tcs2-24e2179493fa83b73db7bc6748d641d2'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>More information :<\/p>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-9-3da894629ace77743dc4a203d39b2bbb\">\n.av_font_icon.av-mqde7m-1-9-3da894629ace77743dc4a203d39b2bbb{\ncolor:#bob1b5;\nborder-color:#bob1b5;\n}\n.av_font_icon.av-mqde7m-1-9-3da894629ace77743dc4a203d39b2bbb .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-9-3da894629ace77743dc4a203d39b2bbb avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue803' data-av_iconfont='entypo-fontello' ><\/span><\/span>\n<p><a href=\"https:\/\/doi.org\/10.1002\/smll.202505343\" target=\"_blank\" rel=\"noopener\"> https:\/\/doi.org\/10.1002\/smll.202505343<\/a><\/p>\n<p><div  class='avia-button-wrap av-1yorzw-949d1bb3315bdb1fec8584f15f1e6640-wrap avia-button-left  avia-builder-el-21  el_after_av_font_icon  el_before_av_button'><a href='mailto:anthony.treizebre@iemn.fr'  class='avia-button av-1yorzw-949d1bb3315bdb1fec8584f15f1e6640 av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-silver'   aria-label=\"anthony.treizebre@iemn.fr\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >anthony.treizebre@iemn.fr<\/span><\/a><\/div><br \/>\n<div  class='avia-button-wrap av-1yorzw-1-65fda2b0b8f876164bb1c27d58f2ab3c-wrap avia-button-left  avia-builder-el-22  el_after_av_button  avia-builder-el-last'><a href='mailto:fabrizio.cleri@iemn.fr'  class='avia-button av-1yorzw-1-65fda2b0b8f876164bb1c27d58f2ab3c av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-silver'   aria-label=\"fabrizio.cleri@iemn.fr\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >fabrizio.cleri@iemn.fr<\/span><\/a><\/div><\/p>\n<\/div><\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[297],"tags":[],"class_list":["post-76362","post","type-post","status-publish","format-standard","hentry","category-newsletter"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/76362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=76362"}],"version-history":[{"count":17,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/76362\/revisions"}],"predecessor-version":[{"id":76621,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/76362\/revisions\/76621"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=76362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=76362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=76362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}