{"id":72353,"date":"2025-02-06T11:47:00","date_gmt":"2025-02-06T09:47:00","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=72353"},"modified":"2025-02-25T12:03:37","modified_gmt":"2025-02-25T10:03:37","slug":"un-nano-radar-pour-limagerie-cellulaire-microscopie-3d-micro-ondes-et-fluorescence-en-milieu-liquide-2","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/newsletter\/un-nano-radar-pour-limagerie-cellulaire-microscopie-3d-micro-ondes-et-fluorescence-en-milieu-liquide-2.html","title":{"rendered":"Un nano-radar pour l\u2019imagerie cellulaire : microscopie 3D micro-ondes et fluorescence en milieu liquide"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6kfb4m4-5fe157acfb2922d6c407feb1ffed48f7\">\n.flex_column.av-m6kfb4m4-5fe157acfb2922d6c407feb1ffed48f7{\nbackground-color:#efefef;\n}\n<\/style>\n<div  class='flex_column av-m6kfb4m4-5fe157acfb2922d6c407feb1ffed48f7 av_one_full  avia-builder-el-0  el_before_av_hr  avia-builder-el-first  first flex_column_div'     ><section  class='av_textblock_section av-m6jedv7s-f02ac12b1e6a08b878e74e6ad2838672'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6kez784-1fe73fb4b3ef6c606bd74ffef34da566\">\n#top .hr.hr-invisible.av-m6kez784-1fe73fb4b3ef6c606bd74ffef34da566{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-m6kez784-1fe73fb4b3ef6c606bd74ffef34da566 hr-invisible  avia-builder-el-2  el_after_av_one_full  el_before_av_textblock'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-m6jef3f8-4b1f1086f555bb536f399d768a41c089'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h1>Un nano-radar pour l\u2019imagerie cellulaire : microscopie 3D micro-ondes et fluorescence en milieu liquide<\/h1>\n<h2 style=\"text-align: center;\"><span style=\"color: #f16728;\">\u00a0<\/span><\/h2>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6jek97m-f0703278816439aa8e71459b1f9e7835\">\n#top .hr.av-m6jek97m-f0703278816439aa8e71459b1f9e7835{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-m6jek97m-f0703278816439aa8e71459b1f9e7835 .hr-inner{\nwidth:100px;\nborder-color:#f16728;\nmax-width:45%;\n}\n.hr.av-m6jek97m-f0703278816439aa8e71459b1f9e7835 .av-seperator-icon{\ncolor:#f16728;\n}\n<\/style>\n<div  class='hr av-m6jek97m-f0703278816439aa8e71459b1f9e7835 hr-custom  avia-builder-el-4  el_after_av_textblock  el_before_av_one_half  hr-center hr-icon-yes'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue87b' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<div  class='flex_column av-m6jdpaok-1bd26374588bb9bb424562183b62b4b8 av_one_half  avia-builder-el-5  el_after_av_hr  el_before_av_one_half  first flex_column_div'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6jdswo0-e63a1ab9558d0f038f3210deb76b9b3d\">\n#top .av_textblock_section.av-m6jdswo0-e63a1ab9558d0f038f3210deb76b9b3d .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-m6jdswo0-e63a1ab9558d0f038f3210deb76b9b3d'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><blockquote>\n<p class=\"Standard\"><strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-53082-4\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #ff7b00;\"><span style=\"color: #008080;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1524bcfe1dd544a44cfe81886c34073c\">\n.av_font_icon.av-mqde7m-1524bcfe1dd544a44cfe81886c34073c{\ncolor:#ff7b00;\nborder-color:#ff7b00;\n}\n.av_font_icon.av-mqde7m-1524bcfe1dd544a44cfe81886c34073c .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1524bcfe1dd544a44cfe81886c34073c avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue885' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/span><\/span><\/a><\/strong><\/p>\n<p>L\u2019activit\u00e9 \u00e9lectrique des organites cellulaires, comme les mitochondries, joue un r\u00f4le cl\u00e9 en biologie et en m\u00e9decine, mais reste mal comprise. Son lien avec le vieillissement, l\u2019apoptose et des maladies comme le cancer ou le diab\u00e8te soul\u00e8ve des questions essentielles. D\u00e9velopper une interface \u00e9lectronique large bande et calibr\u00e9e permettrait d\u2019explorer ces ph\u00e9nom\u00e8nes et d\u2019ouvrir la voie \u00e0 de nouvelles approches th\u00e9rapeutiques.<\/p>\n<\/blockquote>\n<h5><strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-53082-4\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #ff7b00;\"><span style=\"color: #008080;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-3-9ddbbfcf8e1204fc5bc3927ac48288f3\">\n.av_font_icon.av-mqde7m-3-9ddbbfcf8e1204fc5bc3927ac48288f3{\ncolor:#ff7b00;\nborder-color:#ff7b00;\n}\n.av_font_icon.av-mqde7m-3-9ddbbfcf8e1204fc5bc3927ac48288f3 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-3-9ddbbfcf8e1204fc5bc3927ac48288f3 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span> <\/span><\/span><span style=\"text-decoration: underline;\"><span style=\"color: #808080; text-decoration: underline;\">Les premiers travaux<\/span><\/span><\/a><\/strong><\/h5>\n<p>En 2017, un consortium compos\u00e9 de l&rsquo;IEMN, de l&rsquo;Universit\u00e9 de Californie Irvine, du Centre de m\u00e9decine mitochondriale et \u00e9pig\u00e9nomique de l\u2019H\u00f4pital pour enfants de Philadelphie, aux \u00c9tats-Unis, r\u00e9alise pour la premi\u00e8re fois l\u2019imagerie de mitochondries vivantes en utilisant la microscopie \u00e0 balayage micro-ondes. Les mitochondries, isol\u00e9es de cellules HeLa cultiv\u00e9es, sont fix\u00e9es sur un support en graph\u00e8ne et maintenues en vie gr\u00e2ce \u00e0 un buffer respiratoire qui leur fournit les nutriments n\u00e9cessaires au cycle de Krebs. Les organites sont analys\u00e9s par une mesure capacitive \u00e0 une fr\u00e9quence de 7 GHz.<\/p>\n<h5><strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-53082-4\" target=\"_blank\" rel=\"noopener\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-3-1-c8fdedcec6442f52611db09fc073032b\">\n.av_font_icon.av-mqde7m-3-1-c8fdedcec6442f52611db09fc073032b{\ncolor:#ff7b00;\nborder-color:#ff7b00;\n}\n.av_font_icon.av-mqde7m-3-1-c8fdedcec6442f52611db09fc073032b .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-3-1-c8fdedcec6442f52611db09fc073032b avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/a><\/strong><span style=\"text-decoration: underline; color: #808080;\">Une interface nano-\u00e9lectronique \u00e0 tr\u00e8s large bande pour l\u2019int\u00e9rieur des cellules vivantes avec lecture int\u00e9gr\u00e9e par fluorescence de l\u2019activit\u00e9 m\u00e9tabolique.<br \/>\n<\/span><\/h5>\n<p>En 2020, le consortium r\u00e9alise une avanc\u00e9e majeure en pr\u00e9sentant la toute premi\u00e8re connexion \u00e9lectrique large bande et calibr\u00e9e \u00e0 l\u2019int\u00e9rieur d\u2019une cellule vivante int\u00e9grant une lecture par fluorescence de l\u2019activit\u00e9 m\u00e9tabolique. Des \u00e9talons de calibration de la capacit\u00e9 \u00e0 l\u2019\u00e9chelle nanom\u00e9trique, int\u00e9gr\u00e9s sur puce, sont utilis\u00e9s pour quantifier la r\u00e9ponse micro-ondes avec des images cellulaires obtenues \u00e0 22 GHz. Une telle interface ouvre de nombreuses perspectives pour l\u2019int\u00e9gration des sciences du vivant avec la nano\u00e9lectronique, notamment pour des tests \u00e9lectroniques des dynamiques du potentiel membranaire, l\u2019activation nano\u00e9lectronique de processus cellulaires, ainsi que l\u2019imagerie tomographique par nano-radar de la morphologie des organites vitaux au sein du cytoplasme, tout au long du cycle de vie cellulaire, dans diff\u00e9rents environnements physiologiques et sous diverses conditions pharmacologiques.<\/p>\n<h5><span style=\"text-decoration: underline; color: #808080;\">\u00a0<\/span><\/h5>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6t4tzi4-48dfd75c4d498bba82221a22425211d8\">\n#top .hr.hr-invisible.av-m6t4tzi4-48dfd75c4d498bba82221a22425211d8{\nheight:100px;\n}\n<\/style>\n<div  class='hr av-m6t4tzi4-48dfd75c4d498bba82221a22425211d8 hr-invisible  avia-builder-el-10  el_after_av_textblock  el_before_av_hr'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-sfujoh-160513e48c6ee555680daf9d1b6da8e4\">\n#top .hr.av-sfujoh-160513e48c6ee555680daf9d1b6da8e4{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-sfujoh-160513e48c6ee555680daf9d1b6da8e4 .hr-inner{\nwidth:125;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-sfujoh-160513e48c6ee555680daf9d1b6da8e4 hr-custom  avia-builder-el-11  el_after_av_hr  el_before_av_hr  hr-center hr-icon-yes'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue84e' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6z4hzq6-326276a21f8e0621c7e3fa1756dba512\">\n#top .hr.hr-invisible.av-m6z4hzq6-326276a21f8e0621c7e3fa1756dba512{\nheight:50px;\n}\n<\/style>\n<div  class='hr av-m6z4hzq6-326276a21f8e0621c7e3fa1756dba512 hr-invisible  avia-builder-el-12  el_after_av_hr  el_before_av_textblock'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6je98a0-926e80372703b8dd4483c2112b7b4148\">\n#top .av_textblock_section.av-m6je98a0-926e80372703b8dd4483c2112b7b4148 .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-m6je98a0-926e80372703b8dd4483c2112b7b4148'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h5><strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-53082-4\" target=\"_blank\" rel=\"noopener\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-3-1-2-39a5fe3bb2295eae626f4e1fc366d716\">\n.av_font_icon.av-mqde7m-3-1-2-39a5fe3bb2295eae626f4e1fc366d716{\ncolor:#ff7b00;\nborder-color:#ff7b00;\n}\n.av_font_icon.av-mqde7m-3-1-2-39a5fe3bb2295eae626f4e1fc366d716 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-3-1-2-39a5fe3bb2295eae626f4e1fc366d716 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/a><\/strong> <span style=\"text-decoration: underline;\"><span style=\"color: #999999; text-decoration: underline;\">Microscopie micro-ondes coaxiale 3D et fluorescence \u00e0 super-r\u00e9solution combin\u00e9es : Preuve de concept d\u2019imagerie de cellules vivantes en milieu liquide \u2013 Vers un nano-radar biologique.<\/span><\/span><\/h5>\n<p>En 2024, le m\u00eame consortium poursuit ses travaux en d\u00e9veloppant une nouvelle preuve de concept de microscopie micro-ondes en 3D combin\u00e9e \u00e0 la fluorescence \u00e0 super-r\u00e9solution. Cette nouvelle version repose sur des sondes micro- ou nano-coaxiales afin de pallier au probl\u00e8me du couplage parasite. L\u2019architecture coaxiale am\u00e9liore la r\u00e9solution spatiale et la sensibilit\u00e9 des mesures en r\u00e9duisant l\u2019absorption ind\u00e9sirable du signal micro-ondes par le milieu biologique. Ces avanc\u00e9es jettent les bases d\u2019un v\u00e9ritable nano-radar biologique capable de sonder, en milieu liquide et en temps r\u00e9el, les dynamiques \u00e9lectromagn\u00e9tiques des organites cellulaires.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6jenubk-2d51498c88dc44c60061ccabb10b1621\">\n#top .av_textblock_section.av-m6jenubk-2d51498c88dc44c60061ccabb10b1621 .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-m6jenubk-2d51498c88dc44c60061ccabb10b1621'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h5><strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-53082-4\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #ff7b00;\"><span style=\"color: #008080;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-2-70a66f18ecee0847b59470b90592f8ca\">\n.av_font_icon.av-mqde7m-2-70a66f18ecee0847b59470b90592f8ca{\ncolor:#ff7b00;\nborder-color:#ff7b00;\n}\n.av_font_icon.av-mqde7m-2-70a66f18ecee0847b59470b90592f8ca .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-2-70a66f18ecee0847b59470b90592f8ca avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/span><\/span><\/a><\/strong> <span style=\"text-decoration: underline; color: #808080;\">A suivre<\/span><\/h5>\n<p>En Janvier 2025, METAS, l\u2019Institut f\u00e9d\u00e9ral de m\u00e9trologie suisse, a rejoint le consortium en apportant son expertise dans le d\u00e9veloppement de sondes nano-coaxiales. Ces nouvelles sondes, issues des avanc\u00e9es en nano-fabrication sont actuellement en cours d\u2019int\u00e9gration. Leur d\u00e9ploiement vise \u00e0 \u00e9tendre les capacit\u00e9s du dispositif, tant en termes de r\u00e9solution spatiale que de couverture spectrale. Par ailleurs, ces travaux ouvrent la voie \u00e0 la conception d\u2019un <strong>\u00e9quipement m\u00e9trologique de r\u00e9f\u00e9rence<\/strong>, destin\u00e9 \u00e0 garantir la tra\u00e7abilit\u00e9 et la calibration des mesures micro-ondes \u00e0 l\u2019\u00e9chelle nanom\u00e9trique en environnement biologique. Ces d\u00e9veloppements offrent \u00e9galement de nouvelles perspectives en d\u00e9tection quantique radiofr\u00e9quence en cours d\u2019optimisation. L\u2019objectif est d\u2019explorer des r\u00e9gimes de mesure encore inaccessibles, avec une pr\u00e9cision et une stabilit\u00e9 accrues.<\/p>\n<\/div><\/section><\/p><\/div>\n<div  class='flex_column av-pkjtzx-ae0e0864cfa130247f8f40aa1ae8dbfb av_one_half  avia-builder-el-17  el_after_av_one_half  el_before_av_hr  flex_column_div'     ><p><section  class='av_textblock_section av-m6je9ub6-2b241e8a69fef25c12221b3f2c441c5c'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/K-Haddadi-fig2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-72357\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/K-Haddadi-fig2.jpg\" alt=\"\" width=\"400\" height=\"456\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/K-Haddadi-fig2.jpg 600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/K-Haddadi-fig2-263x300.jpg 263w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/K-Haddadi-fig2-11x12.jpg 11w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><\/p>\n<p><em><strong>(a)<\/strong> Un analyseur de r\u00e9seau vectoriel micro-ondes (Keysight N5222A PNA) mesure le signal r\u00e9fl\u00e9chi par une pointe AFM m\u00e9tallique. Un scanner AFM standard est utilis\u00e9 pour d\u00e9placer la pointe AFM au-dessus de l\u2019\u00e9chantillon \u00e9tudi\u00e9. <strong>(b)<\/strong> Le circuit \u00e9lectrique \u00e9quivalent \u00e0 l&rsquo;extr\u00e9mit\u00e9 de la sonde est principalement constitu\u00e9 de la capacit\u00e9 entre la pointe et le plan de masse, qui varie lorsque la pointe est d\u00e9plac\u00e9e. Cependant, des \u00e9l\u00e9ments parasites ind\u00e9sirables sont \u00e9galement pr\u00e9sents. Bien qu\u2019ils soient suppos\u00e9s constants lors du balayage de la pointe, ils doivent \u00eatre calibr\u00e9s afin d\u2019obtenir une image corrig\u00e9e. <strong>(c)<\/strong> Chambre d\u2019\u00e9chantillon contenant des cellules vivantes et des \u00e9talons calibr\u00e9s, ainsi que le plan de masse \u00e9lectrique optiquement transparent (ITO). <strong>(d)<\/strong> Image MEB des disques de calibration. <strong>(e)<\/strong>Image superpos\u00e9e en champ clair et fluorescence d\u2019une culture de cellules HeLa vivantes. Le marqueur fluorescent TMRE est utilis\u00e9 pour indiquer le potentiel membranaire mitochondrial. <strong>(f)<\/strong>Photographie de la chambre d\u2019\u00e9chantillon<strong>.\u00a0<\/strong><\/em><\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6t4e7yl-9acacd42373b9af487c7d8476f6e98f0\">\n.avia-video.av-m6t4e7yl-9acacd42373b9af487c7d8476f6e98f0{\nbackground-image:url(https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/video-kamel-H.jpg);\n}\n<\/style>\n<div  class='avia-video av-m6t4e7yl-9acacd42373b9af487c7d8476f6e98f0 avia-video-16-9 av-preview-image avia-video-load-always avia-video-html5'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/video_agrandissement_kamel_web.mp4'><video class='avia_video' poster=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/video-kamel-H.jpg\"   preload=\"auto\"  controls id='player_72353_1202662288_130198824'><source src='https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/video_agrandissement_kamel_web.mp4' type='video\/mp4' \/><\/video><\/div><br \/>\n<section  class='av_textblock_section av-m6z96muz-2f0670cde273cde42c974ce73f9adc2b'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Imagerie par microscopie micro-ondes d\u2019une cellule HELA vivante en mode tapping.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6t583xm-3597def24dbdfd405d9b1c1a35b90a5a\">\n#top .hr.av-m6t583xm-3597def24dbdfd405d9b1c1a35b90a5a{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-m6t583xm-3597def24dbdfd405d9b1c1a35b90a5a .hr-inner{\nwidth:125;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-m6t583xm-3597def24dbdfd405d9b1c1a35b90a5a hr-custom  avia-builder-el-21  el_after_av_textblock  el_before_av_textblock  hr-center hr-icon-yes'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue84e' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6jdvgw4-4e10fbe8871ac32cc0c4a990921f9217\">\n#top .av_textblock_section.av-m6jdvgw4-4e10fbe8871ac32cc0c4a990921f9217 .avia_textblock{\ntext-align:justify;\n}\n<\/style>\n<section  class='av_textblock_section av-m6jdvgw4-4e10fbe8871ac32cc0c4a990921f9217'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div id=\"attachment_72365\" style=\"width: 460px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Partie-4-figure-1.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-72365\" class=\"wp-image-72365\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Partie-4-figure-1.jpg\" alt=\"\" width=\"450\" height=\"320\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Partie-4-figure-1.jpg 650w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Partie-4-figure-1-300x213.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Partie-4-figure-1-18x12.jpg 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Partie-4-figure-1-260x185.jpg 260w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/a><p id=\"caption-attachment-72365\" class=\"wp-caption-text\">Mise en \u0153uvre du syst\u00e8me pour la preuve de concept de la microscopie micro-ondes 3D coaxiale combin\u00e9e \u00e0 la fluorescence haute r\u00e9solution.<\/p><\/div>\n<div id=\"attachment_72374\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Pattie-4-figure-2.gif\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-72374\" class=\"wp-image-72374\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2025\/02\/Pattie-4-figure-2.gif\" alt=\"\" width=\"600\" height=\"156\" \/><\/a><p id=\"caption-attachment-72374\" class=\"wp-caption-text\">(a) Mesure large bande au-dessus d\u2019une plaque m\u00e9tallique avec une distance de s\u00e9paration fix\u00e9e \u00e0 80 \u03bcm. (b) Coefficient de r\u00e9flexion complexe S11 mesur\u00e9 en fonction de la position absolue en Z pour les fr\u00e9quences de test 3,75375 GHz, 3,99335 GHz et 5,76040 GHz (MUT = cellules HeLa [ATCC CCL-2] dans un buffer physiologique, ZSTEP = 50 \u03bcm). IFBW = 100 Hz.<\/p><\/div>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-m6kg6dp4-0a0341a118e8e82382779cf552f32e66\">\n#top .hr.av-m6kg6dp4-0a0341a118e8e82382779cf552f32e66{\nmargin-top:30px;\nmargin-bottom:30px;\n}\n.hr.av-m6kg6dp4-0a0341a118e8e82382779cf552f32e66 .hr-inner{\nwidth:550;\nmax-width:45%;\n}\n<\/style>\n<div  class='hr av-m6kg6dp4-0a0341a118e8e82382779cf552f32e66 hr-custom  avia-builder-el-23  el_after_av_one_half  el_before_av_textblock  hr-center hr-icon-yes'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><span class='av-seperator-icon' aria-hidden='true' data-av_icon='\ue84e' data-av_iconfont='entypo-fontello'><\/span><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-m6kfyqx5-5c24a44740cc8a2bc2d2d74fa2861b11'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>References<\/p>\n<p>[1] Li, Jinfeng, Zahra Nernati, Kamel Haddadi, Douglas C. Wallace, and Peter J. Burke. \u00ab\u00a0Scanning microwave microscopy of vital mitochondria in respiration buffer.\u00a0\u00bb In 2018 IEEE\/MTT-S International Microwave Symposium-IMS, pp. 115-118. IEEE, 2018. <a href=\"https:\/\/hal.science\/hal-03224648v1\" target=\"_blank\" rel=\"noopener\">https:\/\/hal.science\/hal-03224648v1<\/a><\/p>\n<p>[2] Ren, Dandan, Zahra Nemati, Chia-Hung Lee, Jinfeng Li, Kamel Haddadi, Douglas C. Wallace, and Peter J. Burke. \u00ab\u00a0An ultra-high bandwidth nano-electronic interface to the interior of living cells with integrated fluorescence readout of metabolic activity.\u00a0\u00bb Scientific reports 10, no. 1 (2020): 10756.\u00a0 <a href=\"https:\/\/hal.science\/hal-03224644v1\" target=\"_blank\" rel=\"noopener\">https:\/\/hal.science\/hal-03224644v1<\/a><\/p>\n<p>[3] Lee, Chia-Hung, Kamel Haddadi, and Peter J. Burke. \u00ab\u00a0Combined Super-Resolution Fluorescence and Coaxial 3-D Scanning Microwave Microscopy: Proof-of-Concept In-Liquid Live-Cell Imaging: Toward a Biological Nano-Radar.\u00a0\u00bb IEEE Microwave and Wireless Technology Letters (2024).\u00a0 <a href=\"https:\/\/hal.science\/hal-04815101v1\" target=\"_blank\" rel=\"noopener\">https:\/\/hal.science\/hal-04815101v1<\/a><\/p>\n<p>[4] Kamel Haddadi, IEEE Member, Cl\u00e9ment Lenoir, Mohamed Sebbache, Chia-Hung Lee, Peter Burke, IEEE fellow. \u00ab\u00a0Microwave Imaging with Open-Ended Coaxial Probes.\u00a0\u00bb IEEE 2024 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), Delft, Netherlands, (2024). <a href=\"https:\/\/hal.science\/hal-04946860v1\" target=\"_blank\" rel=\"noopener\">https:\/\/hal.science\/hal-04946860v1<\/a><\/p>\n<p>Contact us:<\/p>\n<p><div  class='avia-button-wrap av-rpqvoq-9e49efa2cc96472cdaff5b05d2780920-wrap avia-button-left  avia-builder-el-25  el_before_av_button  avia-builder-el-first'><a href='mailto:kamel.haddadi@iemn.fr'  class='avia-button av-rpqvoq-9e49efa2cc96472cdaff5b05d2780920 av-link-btn avia-icon_select-yes-left-icon avia-size-light avia-position-left avia-color-silver'   aria-label=\"Kamel Haddadi\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Kamel Haddadi<\/span><\/a><\/div> <div  class='avia-button-wrap av-rpqvoq-a6916327a67a975f1ede808483948a8a-wrap avia-button-left  avia-builder-el-26  el_after_av_button  avia-builder-el-last'><a href='mailto:pburke@uci.edu'  class='avia-button av-rpqvoq-a6916327a67a975f1ede808483948a8a av-link-btn avia-icon_select-yes-left-icon avia-size-light avia-position-left avia-color-silver'   aria-label=\"Peter J. Burke\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Peter J. Burke<\/span><\/a><\/div><\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[297],"tags":[],"class_list":["post-72353","post","type-post","status-publish","format-standard","hentry","category-newsletter"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/72353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=72353"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/72353\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=72353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=72353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=72353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}