{"id":55530,"date":"2022-12-01T12:20:40","date_gmt":"2022-12-01T10:20:40","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=55530"},"modified":"2022-12-01T12:20:40","modified_gmt":"2022-12-01T10:20:40","slug":"these-v-mishyn-le-role-de-la-chimie-de-surface-sur-la-performance-de-biocapteurs-a-base-de-graphene","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/these\/these-2021\/these-v-mishyn-le-role-de-la-chimie-de-surface-sur-la-performance-de-biocapteurs-a-base-de-graphene.html","title":{"rendered":"THESIS: V. MISHYN - The role of surface chemistry on the performance of graphene-based biosensors"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_heading  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_58_160m0z6ckxwkd\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;border-style:solid;border-color:#000;background-position:0% 0%;background-repeat:no-repeat;width:180px;height:30px;left:0px;top:231px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-quote-right\" style=\"color:#ffffff;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>ACTUALITES<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-55530'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lb4xdr4b-bac236ddfb35d1e0f3849ddf22625643\">\n#top .av-special-heading.av-lb4xdr4b-bac236ddfb35d1e0f3849ddf22625643{\nmargin:0 0 10px 0;\npadding-bottom:4px;\n}\nbody .av-special-heading.av-lb4xdr4b-bac236ddfb35d1e0f3849ddf22625643 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-lb4xdr4b-bac236ddfb35d1e0f3849ddf22625643 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-lb4xdr4b-bac236ddfb35d1e0f3849ddf22625643 av-special-heading-h2  avia-builder-el-1  el_after_av_layerslider  el_before_av_hr  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >THESIS: V. MISHYN - The role of surface chemistry on the performance of graphene-based biosensors <\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-18u73nj-dad6a947580930e400fc42ba200e80f1\">\n#top .hr.av-18u73nj-dad6a947580930e400fc42ba200e80f1{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n.hr.av-18u73nj-dad6a947580930e400fc42ba200e80f1 .hr-inner{\nwidth:100%;\n}\n<\/style>\n<div  class='hr av-18u73nj-dad6a947580930e400fc42ba200e80f1 hr-custom  avia-builder-el-2  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jriy64i8-2f4600354c0449b610997916bbd9b6bc'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" >\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13ewzjw-68e036126b913e5028f77311dc66b825\">\n.av_font_icon.av-13ewzjw-68e036126b913e5028f77311dc66b825{\ncolor:#bfbfbf;\nborder-color:#bfbfbf;\n}\n.av_font_icon.av-13ewzjw-68e036126b913e5028f77311dc66b825 .av-icon-char{\nfont-size:60px;\nline-height:60px;\n}\n<\/style>\n<span  class='av_font_icon av-13ewzjw-68e036126b913e5028f77311dc66b825 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue8c9' data-av_iconfont='entypo-fontello' ><\/span><\/span>\n<p><strong>V. MISHYN<\/strong><\/p>\n<p>Soutenance : <strong> 9 December 2021<br \/>\n<\/strong>Th\u00e8se de doctorat en Electronique, micro\u00e9lectronique, nano\u00e9lectronique et micro-ondes, Universit\u00e9 de Lille, ENGSYS Sciences de l\u2019ing\u00e9nierie et des syst\u00e8mes,<br \/>\nAssociated projects: RENATECH, Flagship GRAPHENE<\/p>\n<\/div><\/section>\n<section  class='av_textblock_section av-jtefqx33-628129dba2299b2ecd65ebfc92eac29d'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div  class='hr av-kjh3zw-4dff888f744b728a1aca9b3a0971493a hr-default  avia-builder-el-6  avia-builder-el-no-sibling'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<h5>Summary:<\/h5>\n<p>Clinical analysis benefits worldwide from a variety of diagnostic tests. Interest in developing new clinical tests stems partly from the need to detect new analytes such as viruses and biomarkers, and partly from a strong demand to reduce the cost, complexity and excessive analysis times of current techniques. Among the many possibilities available today, point-of-care (PoC) devices incorporating graphene and its derivatives are key players. The aim of this work is to study and compare the potential of reduced graphene oxide (rGO) and graphene formed by chemical vapour deposition (CVD) for electrical and electrochemical transduction PoC devices. The complete development of biosensors, from the fabrication of graphene-based transducers to the detection of biological molecules, is presented. Emphasis will be placed on the choice of receptors grafted onto the graphene surface. In this context, non-covalent grafting of receptors using different pyrene-based ligands and covalent grafting using 4 - ((triisopropylsilyl) ethylenyl) benzene diazonium salts will be demonstrated and compared. The detection examples discussed are based on the detection of the E7 capsid protein of the human papillomavirus (HPV) and on the level of cardiac troponin I (cTnI) associated with cardiovascular disease, in various biological samples.<\/p>\n<h5>Abstract:<\/h5>\n<p>Clinical analysis benefits worldwide from a variety of diagnostic tests. The interest in developing new clinical tests is driven by the need to detect new analytes such as viruses and biomarkers, as well as a strong demand to reduce the cost, complexity and excessive analysis time of current techniques. Among the many possibilities available today, point-of-care (PoC) devices incorporating graphene and its derivatives are major players. This work aims to investigate and compare the potential of reduced graphene oxide (rGO) and chemical vapor deposition (CVD) formed graphene for electrical and electrochemical transduction PoC devices. The complete development of biosensors, from the fabrication of graphene-based transducers to the detection of biological molecules, is presented. The focus will be on the choice of receptors grafted on the graphene surface. In this context, non-covalent grafting of receptors using different pyrene-based ligands as well as covalent grafting via 4 - ((triisopropylsilyl) ethylenyl) benzene diazonium salts will be demonstrated and compared. The detection examples discussed are based on the detection of the human papillomavirus (HPV) E7 capsid protein and the level of cardiac troponin I (cTnI) associated with cardiovascular disease in different biological samples.<\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[317],"tags":[],"class_list":["post-55530","post","type-post","status-publish","format-standard","hentry","category-these-2021"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/55530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=55530"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/55530\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=55530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=55530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=55530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}