{"id":54291,"date":"2022-08-30T14:33:06","date_gmt":"2022-08-30T12:33:06","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=54291"},"modified":"2022-09-01T09:35:59","modified_gmt":"2022-09-01T07:35:59","slug":"et-si-les-nouveau-nes-et-les-nourrissons-pouvaient-nous-aider-a-faire-progresser-la-nanomedecine-du-diabete","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/newsletter\/et-si-les-nouveau-nes-et-les-nourrissons-pouvaient-nous-aider-a-faire-progresser-la-nanomedecine-du-diabete.html","title":{"rendered":"Et si les nouveau-n\u00e9s et les nourrissons pouvaient nous aider \u00e0 faire progresser la nanom\u00e9decine du diab\u00e8te ?"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-nk0usz-36f2683419e610837eba21ec6c6f96f3\">\n.flex_column.av-nk0usz-36f2683419e610837eba21ec6c6f96f3{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-nk0usz-36f2683419e610837eba21ec6c6f96f3 av_one_full  avia-builder-el-0  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding'     ><section  class='av_textblock_section av-l7g56yna-261f242fe78f0d610c6d75bcb46747b0'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h4 style=\"text-align: center;\"><b>What if newborns and infants could help us advance diabetes nanomedicine?<\/b><\/h4>\n<hr \/>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/montage_bebe2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-54308 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/montage_bebe2.jpg\" alt=\"\" width=\"600\" height=\"200\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/montage_bebe2.jpg 600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/montage_bebe2-300x100.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/montage_bebe2-18x6.jpg 18w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n<h4 style=\"text-align: center;\"><span style=\"color: #4da4a8;\"><em>\"Collect in your youth, you will find in your old age\".<\/em> <\/span><\/h4>\n<p><strong>In this popular Berber saying, several messages can be heard. One of them is the importance of the health capital of youth for \"aging well\". In reality, this health capital is amassed from the time of the newborn and the infant. If blood sugar is finely regulated and we do not develop diabetes, it is thanks to the amazing capacity of the insulin-secreting cells, called pancreatic beta cells, to adapt its cell mass and the quantity of insulin produced during changes in eating habits or during a pregnancy, for example. In fact, this tremendous plasticity, expressed in the form of a partition or epigenetic code, is created during the feeding periods of newborns and infants. This same code is found in the performing cells of overweight or obese individuals who do not develop diabetes.<\/strong><\/p>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1a41ys3-1b14031d69cb9a8b788a90f2f518e3d6\">\n.flex_column.av-1a41ys3-1b14031d69cb9a8b788a90f2f518e3d6{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-1a41ys3-1b14031d69cb9a8b788a90f2f518e3d6 av_one_half  avia-builder-el-2  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-l7g69cp2-9a1197fa76aa80d2d7577669c0781b8a'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h5>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089\">\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089{\ncolor:#4da4a8;\nborder-color:#4da4a8;\n}\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 .av-icon-char{\nfont-size:30px;\nline-height:30px;\n}\n<\/style>\n<span  class='av_font_icon av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue857' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/h5>\n<p><span style=\"color: #016878;\">All cells in our body have the same DNA. If we were to compare a cell to a computer, this DNA would be the \"hardware\". In fact, all cells also have the same genes. However, the genes are not expressed in the same way in all cells. This is what determines the identity of a cell and, consequently, what characterizes the organs between them.<\/span> This character of a cell is determined by its genetics and by its epigenetics. Epigenetics refers to the hundreds or even thousands of biochemical modifications that a cell's DNA and the proteins that surround it undergo in response to its environment. In fact, these epigenetic modifications constitute a kind of software that programs and above all adapts the functioning of a cell to its environment. Cells specialize in their environment thanks to epigenetics.<\/p>\n<h5>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089\">\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089{\ncolor:#4da4a8;\nborder-color:#4da4a8;\n}\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 .av-icon-char{\nfont-size:30px;\nline-height:30px;\n}\n<\/style>\n<span  class='av_font_icon av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue857' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/h5>\n<p><span style=\"color: #016878;\">Beta cells have the exclusive right to produce insulin, the only hormone that reduces blood sugar in the body. They secrete a significant amount of this hormone into the bloodstream when blood sugar levels rise. Architecturally, beta cells are also very plastic. They are able to increase in volume and number when body mass increases and when overeating rich in fats and carbohydrates is chronic.<\/span> This plasticity and the ability of cells to secrete insulin in response to glucose are established by a software set up between the period of exclusive breastfeeding of the newborn and the period of weaning, characterized by the appearance of a diet rich in sugar. Once the diet is acquired, this software becomes silent in adulthood. However, a body of evidence supports the hypothesis that this software becomes active again in adult beta cells, when we are confronted with weight gain, pregnancy or excessive feeding, in order to increase cell mass and insulin production...<\/p>\n<div  class='avia-button-wrap av-rpqvoq-9ee1afe9be48970673cc7f7eb1463fed-wrap avia-button-left  avia-builder-el-6  el_after_av_font_icon  avia-builder-el-last'><a href='mailto:amar.abderrahmani@univ-lille.fr'  class='avia-button av-rpqvoq-9ee1afe9be48970673cc7f7eb1463fed av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-silver'   aria-label=\"amar.abderrahmani@univ-lille.fr\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >amar.abderrahmani@univ-lille.fr<\/span><\/a><\/div>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-v87uc3-ffbae556f5d5412c5bc5da570605183c\">\n.flex_column.av-v87uc3-ffbae556f5d5412c5bc5da570605183c{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-v87uc3-ffbae556f5d5412c5bc5da570605183c av_one_half  avia-builder-el-7  el_after_av_one_half  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-l7g69cp2-9a1197fa76aa80d2d7577669c0781b8a'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h5>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089\">\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089{\ncolor:#4da4a8;\nborder-color:#4da4a8;\n}\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 .av-icon-char{\nfont-size:30px;\nline-height:30px;\n}\n<\/style>\n<span  class='av_font_icon av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue857' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/h5>\n<p><strong>In diabetic patients, some of the epigenetic modifications that make up this software are altered, suggesting that a breakdown in the software may be responsible for the inability of beta cells to adapt their mass and insulin production to chronic hyperglycemia. Newborns of diabetic parents also have a higher risk of developing diabetes, suggesting that this failure is passed on to offspring. Let's not forget that diabetes is a scourge, which kills several million people in the world every year, and that it reduces on average 6 years of life expectancy to the patient. <\/strong><br \/>\n<strong>\u00a0<\/strong><\/p>\n<h5>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089\">\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089{\ncolor:#4da4a8;\nborder-color:#4da4a8;\n}\n.av_font_icon.av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 .av-icon-char{\nfont-size:30px;\nline-height:30px;\n}\n<\/style>\n<span  class='av_font_icon av-qawvnx-415dcbfc005ab2de3d58f9fb408a4089 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue857' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/h5>\n<p><strong>Some defective sequences of the software have been identified, but much remains to be discovered. Their identification will allow to find new drug targets, whose delivery and transport in the blood could be optimized thanks to nanotechnologies, one of the research axes undertaken by <a href=\"https:\/\/www.iemn.fr\/en\/la-recherche\/les-groupes\/groupe-nbi\/\" target=\"_blank\" rel=\"noopener\">the NBI team...<\/a><\/strong><\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-54303 size-medium\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3-300x296.jpg\" alt=\"\" width=\"300\" height=\"296\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3-300x296.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3-80x80.jpg 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3-12x12.jpg 12w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3-36x36.jpg 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/08\/equipe3.jpg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-qawvnx-8c93e5b0b32cca0a515c5d07bb7925b8\">\n.av_font_icon.av-qawvnx-8c93e5b0b32cca0a515c5d07bb7925b8{\ncolor:#4da4a8;\nborder-color:#4da4a8;\n}\n.av_font_icon.av-qawvnx-8c93e5b0b32cca0a515c5d07bb7925b8 .av-icon-char{\nfont-size:22px;\nline-height:22px;\n}\n<\/style>\n<span  class='av_font_icon av-qawvnx-8c93e5b0b32cca0a515c5d07bb7925b8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue826' data-av_iconfont='entypo-fontello' ><\/span><\/span><strong><a href=\"https:\/\/www.cell.com\/trends\/endocrinology-metabolism\/fulltext\/S1043-2760(22)00054-6\" target=\"_blank\" rel=\"noopener\">2022-jun | Trends in endocrinology and metabolism: TEM 33 (6) , pp.378-389<\/a><\/strong><\/p>\n<\/div><\/section><\/div><\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[297],"tags":[],"class_list":["post-54291","post","type-post","status-publish","format-standard","hentry","category-newsletter"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/54291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=54291"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/54291\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=54291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=54291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=54291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}