{"id":48197,"date":"2021-11-09T11:55:55","date_gmt":"2021-11-09T09:55:55","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=48197"},"modified":"2021-12-10T16:07:05","modified_gmt":"2021-12-10T14:07:05","slug":"these-de-lea-rosselle-development-of-biological-models-to-test-new-treatments-for-chronic-and-infected-wounds","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/these-de-lea-rosselle-development-of-biological-models-to-test-new-treatments-for-chronic-and-infected-wounds.html","title":{"rendered":"Th\u00e8se de L\u00e9a Rosselle \u2013 Development of biological models to test new treatments for chronic and infected wounds"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-jmspet-3ad00e7ddd5b61c9c31ef0cadd3fe5a3\">\n.flex_column.av-jmspet-3ad00e7ddd5b61c9c31ef0cadd3fe5a3{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-jmspet-3ad00e7ddd5b61c9c31ef0cadd3fe5a3 av_one_full  avia-builder-el-0  avia-builder-el-no-sibling  first flex_column_div av-zero-column-padding'     ><section  class='av_textblock_section av-kvrx4kae-c935641fa4a1080ce109e7740a6946d4'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Th\u00e8se de L\u00e9a Rosselle<\/h3>\n<h4 style=\"text-align: center;\">Development of biological models to test new treatments for chronic and infected wounds<\/h4>\n<blockquote>\n<p style=\"text-align: left;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lsfmjh-c1197c6330eaa22ba3742b8dc792c261\">\n.av_font_icon.av-lsfmjh-c1197c6330eaa22ba3742b8dc792c261 .av-icon-char{\nfont-size:30px;\nline-height:30px;\n}\n<\/style>\n<span  class='av_font_icon av-lsfmjh-c1197c6330eaa22ba3742b8dc792c261 avia_animate_when_visible av-icon-style- avia-icon-pos-left av-no-color avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue8c9' data-av_iconfont='entypo-fontello' ><\/span><\/span><strong>Thesis defence<\/strong> : 7 d\u00e9cembre 2021 \u00e0 14h.<\/p>\n<p>IRCICA Amphitheatre - Villeneuve d'Ascq<\/p>\n<\/blockquote>\n<h5>Jury :<\/h5>\n<p>Jean-Luc CRACOWSKI, Professeur, CHU Grenoble Alpes, Rapporteur<br \/>\nTijani GHARBI, Professeur, Universit\u00e9 de Franche-Comt\u00e9, Rapporteur<br \/>\nRachel AUZELY-VELTY, Professeur, Universit\u00e9 Grenoble Alpes, Examinatrice<br \/>\nAnna-Rita CANTELMO, Professeur,\u00a0Institut Pasteur, Examinatrice<br \/>\nSabine SZUNERITS, Professeur, Universit\u00e9 de Lille, Directrice de th\u00e8se<br \/>\nNadia SKANDRANI, Docteur, Co-encadrante de th\u00e8se, TissueAegis<\/p>\n<h5>Summary:<\/h5>\n<p>La peau poss\u00e8de d&rsquo;excellentes propri\u00e9t\u00e9s de r\u00e9g\u00e9n\u00e9ration qui lui permettent de cicatriser rapidement en cas de blessure. Si les plaies ne gu\u00e9rissent pas de mani\u00e8re ordonn\u00e9e et spontan\u00e9e, des plaies chroniques se d\u00e9veloppent et trouver un traitement efficace reste un d\u00e9fi mondial. Bien qu&rsquo;il existe une myriade de th\u00e9rapies et de pansements, tr\u00e8s peu se sont av\u00e9r\u00e9s efficaces pour favoriser la gu\u00e9rison de ces plaies. Une nouvelle avanc\u00e9e consistant \u00e0 int\u00e9grer des nanomat\u00e9riaux dans des pansements cicatrisants combin\u00e9e \u00e0 l&rsquo;administration transdermique de m\u00e9dicaments semble une solution innovante et encourageante. Actuellement, les \u00e9tudes sont principalement men\u00e9es sur des mod\u00e8les animaux, ce qui peut limiter la transf\u00e9rabilit\u00e9 directe \u00e0 l&rsquo;homme et poser des probl\u00e8mes \u00e9thiques. Certaines de ces limitations peuvent \u00eatre surmont\u00e9es en utilisant des mod\u00e8les de peau ex vivo obtenus \u00e0 partir de d\u00e9chets hospitaliers provenant de chirurgie esth\u00e9tique, comme d\u00e9crit dans ce travail. La viabilit\u00e9 des \u00e9chantillons de peau nous permet de tester les traitements sur une p\u00e9riode de 7 jours. Le mod\u00e8le de peau humaine ex vivo d\u00e9velopp\u00e9 s&rsquo;est av\u00e9r\u00e9 prometteur dans le contexte des plaies colonis\u00e9es par des bact\u00e9ries en suivant l&rsquo;impact de la structure de la peau, le profil d&rsquo;expression g\u00e9n\u00e9tique et la colonisation des bact\u00e9ries. Il pourrait alors \u00eatre utilis\u00e9 pour analyser les performances de nouveaux pansements tels que des hydrogels activables par la lumi\u00e8re proche infrarouge, des cryogels photothermiquement actifs et des micro-aiguilles activables par photothermie.<\/p>\n<h5>Abstract:<\/h5>\n<p>Skin processes excellent regeneration properties allowing its rapid healing upon dermal injury. If wounds fail to heal in an orderly and timely manner, chronic wounds (e.g. diabetic foot ulcers, venous leg ulcers, pressure ulcers, etc.) develop and their treatment remains a global challenge. In addition, these diseases might be accompanied by severe infections. While a myriad of topical therapies and dressings are available, very few have shown to be effective in promoting wound repair. The integration of nanomaterials into wound healing bandages combined with transdermal drug delivery are such innovative dressings for both wound healing and infection treatment. These approaches seem to be adapted to overcome current developments in local passive therapies that have shown nonsignificant efficacy. Efficiently testing is currently mainly conducted on animal models, which can limit direct transferability to humans and poses ethnic issues. Some of these limitations can be overcome by using ex vivo skin models obtained from leftover skin parts after esthetical surgery, as described in this work. The viability of the skin samples allows us to test treatments over a period of 7 days. The developed ex vivo human skin model proved promising in the context of bacteria colonized wounds by following skin structure impact, gene expression profile and bacteria colonization. It could be in addition used to indicate the performance of novel skin bandages such as near-infrared light activatable hydrogels, antibacterial peptide loaded photothermally active cryogels and photothermal activatable microneedles.<\/p>\n<\/div><\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":48203,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-48197","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/48197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=48197"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/48197\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/48203"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=48197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=48197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=48197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}