{"id":47992,"date":"2021-10-15T12:05:19","date_gmt":"2021-10-15T10:05:19","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=47992"},"modified":"2021-11-29T11:18:59","modified_gmt":"2021-11-29T09:18:59","slug":"these-de-melanie-lavancier-approche-heuristique-pour-relever-les-defis-de-la-spectroscopie-terahertz-dans-le-domaine-temporel-pour-la-biologie","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/these-de-melanie-lavancier-approche-heuristique-pour-relever-les-defis-de-la-spectroscopie-terahertz-dans-le-domaine-temporel-pour-la-biologie.html","title":{"rendered":"Th\u00e8se de M\u00e9lanie Lavancier \u2013 Approche heuristique pour relever les d\u00e9fis de la spectroscopie TeraHertz dans le domaine temporel pour la biologie"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_full-25347b0a799d5b9f7058434b2a9c3182\">\n.flex_column.av-av_one_full-25347b0a799d5b9f7058434b2a9c3182{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_full-25347b0a799d5b9f7058434b2a9c3182 av_one_full  avia-builder-el-0  avia-builder-el-no-sibling  first flex_column_div av-zero-column-padding'     ><section  class='av_textblock_section av-kus7177k-a63647a55287f3d66c23180a8a83ace3'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>Th\u00e8se \u2013 Approche heuristique pour relever les d\u00e9fis de la spectroscopie TeraHertz dans le domaine temporel pour la biologie<\/h4>\n<blockquote>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_font_icon-75acef453ae55ba5c8e347ae6517e93b\">\n.av_font_icon.av-av_font_icon-75acef453ae55ba5c8e347ae6517e93b .av-icon-char{\nfont-size:30px;\nline-height:30px;\n}\n<\/style>\n<span  class='av_font_icon av-av_font_icon-75acef453ae55ba5c8e347ae6517e93b avia_animate_when_visible av-icon-style- avia-icon-pos-left av-no-color avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue8c9' data-av_iconfont='entypo-fontello' ><\/span><\/span>\n<p>M\u00e9lanie Lavancier<\/p>\n<p>Soutenance de th\u00e8se : 15 octobre 2021 \u00e0 10h<\/p>\n<p>Amphitheater of the IEMN - Central Laboratory - Villeneuve d'Ascq<\/p>\n<\/blockquote>\n<h5>Jury :<\/h5>\n<p>\u2013 Fr\u00e9d\u00e9ric GARET, Professeur des Universit\u00e9s, IEMP-LAHC, rapporteur<br \/>\n\u2013 Guilhem GALLOT, Directeur de recherche, LOB, rapporteur<br \/>\n\u2013 Dominique COQUILLAT, Directrice de recherche, L2C, examinatrice<br \/>\n\u2013 Sophie ELIET BAROIS, Ing\u00e9nieur de recherche, IEMN, examinateur<br \/>\n\u2013 Romain PERETTI, Charg\u00e9 de recherche, IEMN, encadrant de th\u00e8se<br \/>\n\u2013 Jean-Fran\u00e7ois LAMPIN, Directeur de recherche, IEMN, directeur de th\u00e8se<\/p>\n<h5>Summary:<\/h5>\n<p>Le domaine TeraHertz (THz) est de plus en plus attractif gr\u00e2ce \u00e0 ses propri\u00e9t\u00e9s particuli\u00e8res. Il se situe \u00e0 la limite haute des fr\u00e9quences pour l\u2019\u00e9lectronique et entre naturellement en jeu pour de nombreuses applications en t\u00e9l\u00e9communications. De plus, la faible \u00e9nergie du photon THz le rend non ionisant, ce qui cr\u00e9e des applications dans des domaines vari\u00e9s tels que la s\u00e9curit\u00e9, le contr\u00f4le non-destructif dans l\u2019industrie, ou la conservation d\u2019art. Un autre important domaine d\u2019application est la biologie.<br \/>\nLe nombre d\u2019articles publi\u00e9s dans la litt\u00e9rature ces vingt derni\u00e8res ann\u00e9es n\u2019a fait qu\u2019augmenter, ce qui a \u00e9t\u00e9 rendu possible par les avanc\u00e9es sur les dispositifs de spectroscopie THz dans le domaine temporel. De nombreuses \u00e9tudes ont \u00e9t\u00e9 r\u00e9alis\u00e9es sur des sucres, des solvants, ainsi que sur de l\u2019ADN et des prot\u00e9ines. Cependant, il n\u2019y a toujours pas de consensus dans la communaut\u00e9 THz concernant les protocoles exp\u00e9rimentaux et d\u2019analyse des donn\u00e9es \u00e0 impl\u00e9menter.<br \/>\nCette th\u00e8se expose trois avanc\u00e9es dans cette direction. Tout d\u2019abord, elle pr\u00e9sente un protocole de \u00ab\u00a0fit\u00a0\u00bb (ou d\u2019ajustement des donn\u00e9es) dans le domaine temporel fiable et quantitatif, ainsi qu\u2019un crit\u00e8re de comparaison, ce qui permet une plus grande confiance dans les r\u00e9sultats obtenus et de les comparer \u00e0 la th\u00e9orie. Nous pouvons donc avancer et analyser des \u00e9chantillons toujours plus complexes, de mani\u00e8re \u00e0 \u00eatre de plus en plus proche des conditions in vivo pour les \u00e9chantillons biologiques. En effet, j\u2019ai pu fournir de nouvelles perspectives \u00e0 l\u2019analyse de l\u2019eau liquide, qui est un sujet phare depuis les d\u00e9buts de la spectroscopie TeraHertz \u00e0 domaine temporel, et sur l\u2019influence des ions et des prot\u00e9ines sur la structure de son r\u00e9seau. En outre, nous avons rendu possible l\u2019analyse de petits \u00e9chantillons, que ce soit en taille ou en quantit\u00e9, gr\u00e2ce \u00e0 notre dispositif appel\u00e9 \u00ab\u00a0papillon\u00a0\u00bb.<br \/>\nLes protocoles ainsi que le logiciel de fit peuvent encore \u00eatre am\u00e9lior\u00e9s, mais ils ont permis de fournir des r\u00e9sultats fiables et donnent un crit\u00e8re pour la comparaison d\u2019information. Nous esp\u00e9rons que ce travail ouvrira la voie \u00e0 une meilleure compr\u00e9hension et \u00e0 de plus complexes exp\u00e9riences sur les \u00e9chantillons biologiques gr\u00e2ce \u00e0 la spectroscopie TeraHertz dans le domaine temporel.<\/p>\n<h5>Abstract:<\/h5>\n<p>There is growing interest for the terahertz (THz) frequency range due to several specificities. Located at the highest frequencies reached in electronics, there are applications for faster data bit rate in telecommunications. Moreover, due to the low energy of the photons, there are also applications in security, non-destructive monitoring for the industry and art conservation. Since this radiation is non-ionizing, another field of interest is biology.<br \/>\nThese last two decades have seen the rise of published articles in the literature, made possible by the advances in terahertz time-domain spectroscopy setups. Many studies have been conducted on sugars, solvents, and even DNA and proteins. However, there is still no consensus in the Terahertz (THz) community on the experimental or data analysis protocols to implement.<br \/>\nThis thesis displays three advances towards this direction. First, it presents a reliable and quantitative time-domain fitting process with a comparison metric that makes it possible to trust the results obtained and compare them to the theory. This enables us to move forward and analyze more and more complex samples, to come closer to in vivo conditions for biological samples. Indeed, I was able to provide more insight on the analysis of liquid water, which has been a great topic of interest since the beginning of THz time-domain spectroscopy, and on the influence of ions and proteins on the structure of its network. Furthermore, we made it possible for smaller samples, either in size or in quantity, to be analyzed as well thanks to our butterfly device. The protocols as well as the fitting software can still be improved, but they provide trustworthy results and give a criterion for comparison of data. We foresee that this will lead the way to a better understanding and more intricate experiments with THz time-domain spectroscopy for biology.<\/p>\n<\/div><\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":47995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,40],"tags":[],"class_list":["post-47992","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-articles-temporaires-anglais"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/47992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=47992"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/47992\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/47995"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=47992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=47992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=47992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}