{"id":45782,"date":"2021-06-04T08:52:09","date_gmt":"2021-06-04T06:52:09","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=45782"},"modified":"2021-06-14T10:11:19","modified_gmt":"2021-06-14T08:11:19","slug":"carbon-quantum-dots-as-a-dual-platform-for-the-inhibition-and-light-based-destruction-of-collagen-fibers-implications-for-the-treatment-of-eye-floaters","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/carbon-quantum-dots-as-a-dual-platform-for-the-inhibition-and-light-based-destruction-of-collagen-fibers-implications-for-the-treatment-of-eye-floaters.html","title":{"rendered":"IEMN in Nanoscale Horizons : Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-d3e32e19b7b525dfd88dd3006bf897f8\">\n#top .av-special-heading.av-av_heading-d3e32e19b7b525dfd88dd3006bf897f8{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-d3e32e19b7b525dfd88dd3006bf897f8 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-d3e32e19b7b525dfd88dd3006bf897f8 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-d3e32e19b7b525dfd88dd3006bf897f8 av-special-heading-h3  avia-builder-el-0  el_before_av_one_full  avia-builder-el-first'><h3 class='av-special-heading-tag'  itemprop=\"headline\"  >Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1c4syc6-94faa6a3bcb119c7da67e87ac3ebd0e8\">\n.flex_column.av-1c4syc6-94faa6a3bcb119c7da67e87ac3ebd0e8{\nborder-radius:0px 0px 0px 0px;\npadding:10px 10px 10px 10px;\n}\n<\/style>\n<div  class='flex_column av-1c4syc6-94faa6a3bcb119c7da67e87ac3ebd0e8 av_one_full  avia-builder-el-1  el_after_av_heading  el_before_av_one_full  first flex_column_div'     ><section  class='av_textblock_section av-kphyozz2-8c66b8a8faa0d281c6103760a79ef50c'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><em>Alexandre Barras (a), F\u00e9lix Sauvage (b), In\u00e8s de Hoon (ab), Kevin Braeckmans(b), Dawei Hua(b), Ga\u00ebtan Buvat(a), Juan C. Fraire(b), Christophe Lethien (a), J. Sebag (cd),\u00a0Michael Harrington(e), Amar Abderrahmani(a), Rabah Boukherroub(a),\u00a0Stefaan De Smedt (b) and Sabine Szunerits (a)<br \/>\n<\/em><\/p>\n<hr \/>\n<p><em>(a) Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 \u2013 IEMN, F-59000 Lille, France. E-mail: sabine.szunerits@univ-lille.fr<br \/>\n<\/em><em>(b) Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.\u00a0E-mail: stefaan.desmedt@ugent.be<br \/>\n<\/em><em>(c)VMR Institute for Vitreous Macula Retina, Huntington Beach, California 92647, USA<br \/>\n<\/em><em>(d) Doheny Eye Institute\/UCLA, Los Angeles, California 90033, USA<br \/>\n<\/em><em>(e) Huntington Memorial Research Institute, Pasadena, CA, USA<\/em><\/p>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ib5z5i-15cd252d883d4dea3d2d964c8e4729b0\">\n.flex_column.av-ib5z5i-15cd252d883d4dea3d2d964c8e4729b0{\nborder-radius:0px 0px 0px 0px;\npadding:4px 4px 4px 4px;\nbackground-color:rgba(237,149,18,0.11);\n}\n<\/style>\n<div  class='flex_column av-ib5z5i-15cd252d883d4dea3d2d964c8e4729b0 av_one_full  avia-builder-el-3  el_after_av_one_full  el_before_av_textblock  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-kphyx4qj-38f81da41b3551d3aa4de721100dc387'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><blockquote>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2021\/06\/visuel_oeil.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-45783 alignleft\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2021\/06\/visuel_oeil.jpg\" alt=\"\" width=\"200\" height=\"148\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2021\/06\/visuel_oeil.jpg 200w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2021\/06\/visuel_oeil-16x12.jpg 16w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a>Common in myopia and aging, vitreous opacities arise from\u00a0clumped collagen fibers within the vitreous body that cast shadows\u00a0on the retina, appearing as \u2018floaters\u2019 to the patient. Vitreous\u00a0opacities degrade contrast sensitivity function and can cause\u00a0significant impairment in vision-related quality-of-life, representing\u00a0an unmet and underestimated medical need. One therapeutic\u00a0approach could be the use of versatile light-responsive nanostructures\u00a0which (i) interfere with the formation of collagen fibers\u00a0and\/or (ii) destroy aggregates of vitreous collagen upon pulsedlaser\u00a0irradiation at low fluences. In this work, the potential of\u00a0positively and negatively charged carbon quantum dots (CQDs) to\u00a0interfere with the aggregation of type I collagen is investigated. We\u00a0demonstrate that fibrillation of collagen I is prevented most\u00a0strongly by positively charged CQDs (CQDs-2) and that pulsedlaser\u00a0illumination allowed to destroy type I collagen aggregates and\u00a0vitreous opacities (as obtained from patients after vitrectomy)\u00a0treated with CQDs-2.<\/p>\n<\/blockquote>\n<\/div><\/section><\/div>\n<section  class='av_textblock_section av-kpi14c1i-2e7c142ea5a5aae420bd610f4b95d4b5'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kpi0zxtc-56d342125d06cf9cf05e8a076694fc4d\">\n#top .avia-animated-number.av-kpi0zxtc-56d342125d06cf9cf05e8a076694fc4d .avia-animated-number-title{\ncolor:#8c212c;\n}\n<\/style>\n<a href='https:\/\/doi.org\/10.1039\/D1NH00157D'  title=\"\"  class=\"avia-animated-number av-kpi0zxtc-56d342125d06cf9cf05e8a076694fc4d av-force-default-color avia_animate_when_visible  avia-builder-el-6  el_after_av_textblock  avia-builder-el-last  avia-color-font-custom\" data-timer=\"3000\"><strong class=\"heading avia-animated-number-title\"><span class='avia-animated-number-icon av-icon-before-number av-icon-char' aria-hidden='true' data-av_icon='\ue803' data-av_iconfont='entypo-fontello'><\/span><\/strong><div class=\"avia-animated-number-content\"><p>Learn more in the journal Nanoscale Horizons<\/p>\n<\/div><\/a>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":46037,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,30],"tags":[],"class_list":["post-45782","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-breves"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/45782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=45782"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/45782\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/46037"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=45782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=45782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=45782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}