{"id":42903,"date":"2020-04-03T09:24:22","date_gmt":"2020-04-03T07:24:22","guid":{"rendered":"https:\/\/www.iemn.fr\/articles-temporaires-anglais\/un-patch-trans-dermique-pour-le-traitement-de-maladies-chroniques-telles-que-le-diabete-2.html"},"modified":"2020-11-09T09:26:01","modified_gmt":"2020-11-09T07:26:01","slug":"un-patch-trans-dermique-pour-le-traitement-de-maladies-chroniques-telles-que-le-diabete-2","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/newsletter\/un-patch-trans-dermique-pour-le-traitement-de-maladies-chroniques-telles-que-le-diabete-2.html","title":{"rendered":"A trans-dermal patch for the treatment of chronic diseases such as diabetes"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_heading  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_58_edsby2eguc1a\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;border-style:solid;border-color:#000;background-position:0% 0%;background-repeat:no-repeat;width:180px;height:30px;left:0px;top:231px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-quote-right\" style=\"color:#ffffff;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>ACTUALITES<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-42903'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kha7z6u2-693b0a24ad37f7c918613d3bf0dca8d3\">\n#top .av-special-heading.av-kha7z6u2-693b0a24ad37f7c918613d3bf0dca8d3{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-kha7z6u2-693b0a24ad37f7c918613d3bf0dca8d3 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-kha7z6u2-693b0a24ad37f7c918613d3bf0dca8d3 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-kha7z6u2-693b0a24ad37f7c918613d3bf0dca8d3 av-special-heading-h3  avia-builder-el-1  el_after_av_layerslider  el_before_av_textblock  avia-builder-el-first'><h3 class='av-special-heading-tag'  itemprop=\"headline\"  >A trans-dermal patch for the treatment of chronic diseases such as diabetes.<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-k8juor33-d27298ac9c58f3bf3e1aadf9c2105b17'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/04\/patch.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-40019\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/04\/patch.png\" alt=\"\" width=\"318\" height=\"248\" \/><\/a><\/p>\n<p>Glycemic control, necessary to reduce chronic complications in type 1 diabetes, often requires multiple daily injections of insulin. The discomfort associated with the use of needles often leads diabetic patients to become discouraged or even neglect their own therapeutic management.<\/p>\n<p>Today, several technological developments are underway to offer alternative solutions to compensate for (multiple) daily injections of insulin. Transdermal administration of insulin, a painless and simple approach, is an interesting alternative and presents several advantages such as the possibility of prolonged and on-demand treatment. However, the transdermal delivery of insulin is limited by the low permeability of the outermost epidermal layer (stratum corneum), which only allows the passage of hydrophobic molecules with a molecular weight below 500 Da.<\/p>\n<p>In this work*, we have demonstrated the improvement of the permeability of the stratum corneum by thermal activation for insulin permeation. We have developed a new transdermal insulin delivery system that exploits the excellent electrothermal properties of a perforated gold thin film covered with an insulin-loaded graphene layer. By applying a low voltage (power less than 200 mW cm-2), it is possible to reach a stable temperature of 52\u00b0C in a few seconds, which allows the initiation of insulin delivery. This self-powered platform can use commercially available portable battery systems. Thus this transdermal patch, designed using simple technology, represents an advance in the treatment of chronic diseases such as diabetes for which effective and non-invasive insulin dosing remains a major challenge.<\/p>\n<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/nh\/c9nh00576e\"><strong>*Electrothermal patches driving the transdermal delivery of insulin <\/strong><\/a><\/p>\n<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/nh\/c9nh00576e\">Quentin Pagneux, Ran Ye, Li Chengnan, Alexandre Barras, Nathalie Hennuyer, Bart Staels, D. Caina, J. I. Avila Osses, Amar Abderrahmani, Val\u00e9rie Plaisance, Val\u00e9rie Pawlowski, Rabah Boukherroub, Sorin Melinte and Sabine Szunerits <\/a><\/p>\n<p><strong><em>Nanoscale Horizons<\/em><\/strong>, 2020, <strong>5<\/strong>, 663-670. <a href=\"https:\/\/doi.org\/10.1039\/C9NH00576E\">https:\/\/doi.org\/10.1039\/C9NH00576E<\/a><\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":40019,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[297],"tags":[300],"class_list":["post-42903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsletter","tag-nl1"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/42903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=42903"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/42903\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/40019"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=42903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=42903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=42903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}