{"id":40981,"date":"2020-05-18T16:37:25","date_gmt":"2020-05-18T14:37:25","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=40981"},"modified":"2020-07-08T09:31:26","modified_gmt":"2020-07-08T07:31:26","slug":"projet-limms-ugsf-canther-iemn-2","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/newsletter\/projet-limms-ugsf-canther-iemn-2.html","title":{"rendered":"LIMMS-UGSF-CANTHER-IEMN project"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_one_full  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_52_91ac7ynla2rk\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/11\/sliders_groupe_physique-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;background-position:0% 0%;background-repeat:no-repeat;mix-blend-mode:normal;top:231px;left:0px;height:30px;width:350px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-user-circle\" style=\"color:#f2f2f2;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>GROUPE DE RECHERCHE : PHYSIQUE<\/ls-layer><\/div><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/12\/sliders_groupe_physique2-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;background-position:0% 0%;background-repeat:no-repeat;mix-blend-mode:normal;top:231px;left:0px;height:30px;width:350px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-user-circle\" style=\"color:#f2f2f2;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>GROUPE DE RECHERCHE : PHYSIQUE<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-40981'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-29v6p4n-41595c6549df29e2bf7bd524d56ff827\">\n.flex_column.av-29v6p4n-41595c6549df29e2bf7bd524d56ff827{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-29v6p4n-41595c6549df29e2bf7bd524d56ff827 av_one_full  avia-builder-el-1  el_after_av_layerslider  el_before_av_one_fifth  avia-builder-el-first  first flex_column_div av-zero-column-padding'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-k5sa1h-53aa117b430af6f64b8512981c15bc1c\">\n#top .av-special-heading.av-k5sa1h-53aa117b430af6f64b8512981c15bc1c{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-k5sa1h-53aa117b430af6f64b8512981c15bc1c .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-k5sa1h-53aa117b430af6f64b8512981c15bc1c .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-k5sa1h-53aa117b430af6f64b8512981c15bc1c av-special-heading-h2  avia-builder-el-2  el_before_av_textblock  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >LIMMS-UGSF-CANTHER-IEMN project<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-ka86lfrr-0c27d64842a31ec9a77fcc290594166b'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>Researchers from Lille and Tokyo have joined forces to design specific sensors for proteins in the SARS-CoV-2 virus.<br \/>\nSimulations aim to elucidate the molecular mechanisms of recognition and interaction of these proteins.<\/h4>\n<h4><\/h4>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1bqr0nr-f8fcb2528cc89f56f1f9778d46bfb924\">\n.flex_column.av-1bqr0nr-f8fcb2528cc89f56f1f9778d46bfb924{\nborder-radius:0px 0px 0px 0px;\npadding:10px 10px 10px 10px;\nbackground-color:#f2f2f2;\n}\n<\/style>\n<div  class='flex_column av-1bqr0nr-f8fcb2528cc89f56f1f9778d46bfb924 av_one_fifth  avia-builder-el-4  el_after_av_one_full  el_before_av_four_fifth  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-ka86qyyp-9888a8ecff1010d58c37b3fdc30dfe8e'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: center;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-40860\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2-159x300.jpg\" alt=\"\" width=\"159\" height=\"300\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2-159x300.jpg 159w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2.jpg 210w\" sizes=\"auto, (max-width: 159px) 100vw, 159px\" \/><\/a><\/p>\n<p><em>The image shows the Spike protein (grey-cyan) interacting with the ACE2 human receptor (blue) and a candidate ssDNA aptamer (red) binding to the same receptor binding site.<\/em><\/p>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-jdv1o7-0968744bbdeba48db32ef81d31b17dde\">\n.flex_column.av-jdv1o7-0968744bbdeba48db32ef81d31b17dde{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-jdv1o7-0968744bbdeba48db32ef81d31b17dde av_four_fifth  avia-builder-el-6  el_after_av_one_fifth  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-ka86smn1-65ea3e5aaa2426c383bf698f29d49a35'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>In a project involving experimental and modelling teams at LIMMS (Tokyo), IEMN, UGSF and CANTHER CNRS units (Lille), we are using large-scale molecular simulations to design nanoscale quantum-dot sensors, aimed at recognising the 'spike' protein and the N-protein of the SARS-CoV-2 virus, by means of ssDNA aptamers. Very cheap to produce in large quantities, extremely biocompatible with practically no adverse effects, aptamers are capable of specifically binding to targets and modulating or blocking their activity, just like natural antibodies. Generated by an in-vitro selection process from pools of random sequence oligonucleotides (the SELEX technique), a typical aptamer is 10-30 kDa in size (about 30-60 DNA or RNA nucleotides), it binds its target with sub-nanomolar affinity, and can discriminate against closely related targets. Our molecular simulations elucidate the microscopic details of the DNA interaction with key proteins of the virus. Furthermore, in the framework of CoVid-19 innovative therapies, we are investigating the possibility that the same DNA aptamers could actively block, or at least slow down, the \"opening\" mechanism of the S-protein, thereby suppressing or strongly reducing the cell-receptor binding, which is the key lead to virus infection.<\/p>\n<div  class='avia-button-wrap av-rpqvoq-97389e76264eda740505eda4205a7282-wrap avia-button-left  avia-builder-el-8  avia-builder-el-no-sibling'><a href='mailto:fabrizio.cleri@univ-lille.fr'  class='avia-button av-rpqvoq-97389e76264eda740505eda4205a7282 av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-silver'   aria-label=\"Contact: Fabrizio CLERI\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Contact: Fabrizio CLERI<\/span><\/a><\/div>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.iemn.fr\/en\/articles-temporaires\/projet-limms-ugsf-canther-iemn.html\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-40986\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/drapeau_francais_pt.jpg\" alt=\"\" width=\"30\" height=\"17\" \/><\/a><\/p>\n<p><span style=\"color: #ffffff;\">.<\/span><\/p>\n<hr \/>\n<p style=\"text-align: center;\">This work is supported by the national supercomputing initiative GENCI. <a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-40886 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2.jpg\" alt=\"\" width=\"567\" height=\"92\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2.jpg 567w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2-300x49.jpg 300w\" sizes=\"auto, (max-width: 567px) 100vw, 567px\" \/><\/a><\/p>\n<\/div><\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[297],"tags":[291,306,308,42],"class_list":["post-40981","post","type-post","status-publish","format-standard","hentry","category-newsletter","tag-capteur","tag-coronavirus","tag-covid-19","tag-iemn"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/40981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=40981"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/40981\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=40981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=40981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=40981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}