{"id":40855,"date":"2020-05-15T14:37:50","date_gmt":"2020-05-15T12:37:50","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=40855"},"modified":"2020-07-08T09:02:16","modified_gmt":"2020-07-08T07:02:16","slug":"projet-limms-ugsf-canther-iemn","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/newsletter\/projet-limms-ugsf-canther-iemn.html","title":{"rendered":"LIMMS-UGSF-CANTHER-IEMN project"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-29v6p4n-41595c6549df29e2bf7bd524d56ff827\">\n.flex_column.av-29v6p4n-41595c6549df29e2bf7bd524d56ff827{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-29v6p4n-41595c6549df29e2bf7bd524d56ff827 av_one_full  avia-builder-el-0  el_before_av_one_fifth  avia-builder-el-first  first flex_column_div av-zero-column-padding'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-pdx93r-65deb748e194164c61331ba7bef9dddf\">\n#top .av-special-heading.av-pdx93r-65deb748e194164c61331ba7bef9dddf{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-pdx93r-65deb748e194164c61331ba7bef9dddf .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-pdx93r-65deb748e194164c61331ba7bef9dddf .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-pdx93r-65deb748e194164c61331ba7bef9dddf av-special-heading-h2  avia-builder-el-1  el_before_av_textblock  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >LIMMS-UGSF-CANTHER-IEMN project<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-ka86lfrr-0c27d64842a31ec9a77fcc290594166b'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>Researchers from Lille and Tokyo have joined forces to design specific sensors for proteins in the SARS-CoV-2 virus.<br \/>\nSimulations aim to elucidate the molecular mechanisms of recognition and interaction of these proteins.<\/h4>\n<h4><\/h4>\n<\/div><\/section><\/p><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1bqr0nr-f8fcb2528cc89f56f1f9778d46bfb924\">\n.flex_column.av-1bqr0nr-f8fcb2528cc89f56f1f9778d46bfb924{\nborder-radius:0px 0px 0px 0px;\npadding:10px 10px 10px 10px;\nbackground-color:#f2f2f2;\n}\n<\/style>\n<div  class='flex_column av-1bqr0nr-f8fcb2528cc89f56f1f9778d46bfb924 av_one_fifth  avia-builder-el-3  el_after_av_one_full  el_before_av_four_fifth  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-ka86qyyp-9888a8ecff1010d58c37b3fdc30dfe8e'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: center;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-40860\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2-159x300.jpg\" alt=\"\" width=\"159\" height=\"300\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2-159x300.jpg 159w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/virus_covid_fdblc2.jpg 210w\" sizes=\"auto, (max-width: 159px) 100vw, 159px\" \/><\/a><\/p>\n<p><em>Spike protein (grey-cyan) interacting with the human ACE2 receptor (blue) and a candidate ssDNA aptamer (red) binding to the same receptor binding site.<\/em><\/p>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-jdv1o7-0968744bbdeba48db32ef81d31b17dde\">\n.flex_column.av-jdv1o7-0968744bbdeba48db32ef81d31b17dde{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-jdv1o7-0968744bbdeba48db32ef81d31b17dde av_four_fifth  avia-builder-el-5  el_after_av_one_fifth  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-ka86smn1-65ea3e5aaa2426c383bf698f29d49a35'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>In a project involving experimental and modelling teams from LIMMS (Tokyo), IEMN, UGSF and CANTHER (Lille), we are using large-scale molecular simulations to design nanometric quantum sensors, aimed at recognising the 'spike' protein and the N protein of the SARS-CoV-2 virus, by means of ssDNA aptamers. Very cheap, easy to produce in large quantities, extremely biocompatible and with virtually no undesirable effects, aptamers are able to bind specifically to targets and modulate or block their activity, just like natural antibodies. Generated by an in vitro selection process from pools of random sequence oligonucleotides (the SELEX technique), a typical aptamer is 10 to 30 kDa in size (around 30 to 60 nucleotides of DNA or RNA), binds its target with sub-nanomolar affinity and can discriminate between closely related targets. Our molecular simulations elucidate the microscopic details of how DNA interacts with key viral proteins. In addition, in the context of innovative CoVid-19 therapies, we are investigating the possibility that the same DNA aptamers could actively block, or at least slow down, the opening mechanism of protein S, thereby suppressing or greatly reducing the cell's binding to receptors, which is the main means of transmission of infection by the virus.<\/p>\n<p><div  class='avia-button-wrap av-rpqvoq-97389e76264eda740505eda4205a7282-wrap avia-button-left  avia-builder-el-7  avia-builder-el-no-sibling'><a href='mailto:fabrizio.cleri@univ-lille.fr'  class='avia-button av-rpqvoq-97389e76264eda740505eda4205a7282 av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-left avia-color-silver'   aria-label=\"Contact: Fabrizio CLERI\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Contact: Fabrizio CLERI<\/span><\/a><\/div><br \/>\n<a href=\"https:\/\/www.iemn.fr\/en\/articles-temporaires\/projet-limms-ugsf-canther-iemn-2.html\/?preview=true\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-40984\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/drapeau_anglais_pt.jpg\" alt=\"\" width=\"30\" height=\"17\" \/><\/a><\/p>\n<p><span style=\"color: #ffffff;\">.<\/span><\/p>\n<hr \/>\n<p style=\"text-align: center;\">This work is supported by the GENCI national supercomputer initiative. <a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-40886 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2.jpg\" alt=\"\" width=\"567\" height=\"92\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2.jpg 567w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/05\/logos2-300x49.jpg 300w\" sizes=\"auto, (max-width: 567px) 100vw, 567px\" \/><\/a><\/p>\n<\/div><\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[297],"tags":[306,308,42],"class_list":["post-40855","post","type-post","status-publish","format-standard","hentry","category-newsletter","tag-coronavirus","tag-covid-19","tag-iemn"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/40855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=40855"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/40855\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=40855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=40855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=40855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}