{"id":40022,"date":"2020-04-03T09:24:22","date_gmt":"2020-04-03T07:24:22","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=40022"},"modified":"2020-08-27T21:41:08","modified_gmt":"2020-08-27T19:41:08","slug":"un-patch-trans-dermique-pour-le-traitement-de-maladies-chroniques-telles-que-le-diabete","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/un-patch-trans-dermique-pour-le-traitement-de-maladies-chroniques-telles-que-le-diabete.html","title":{"rendered":"Un patch trans-dermique pour le traitement de maladies chroniques telles que le diab\u00e8te"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_heading  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_58_1hlrrcmjbwmuy\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;border-style:solid;border-color:#000;background-position:0% 0%;background-repeat:no-repeat;width:180px;height:30px;left:0px;top:231px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-quote-right\" style=\"color:#ffffff;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>ACTUALITES<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-40022'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-1578c5eb8f83a97ed0a65dee6a1ef613\">\n#top .av-special-heading.av-av_heading-1578c5eb8f83a97ed0a65dee6a1ef613{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-1578c5eb8f83a97ed0a65dee6a1ef613 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-1578c5eb8f83a97ed0a65dee6a1ef613 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-1578c5eb8f83a97ed0a65dee6a1ef613 av-special-heading-h3  avia-builder-el-1  el_after_av_layerslider  el_before_av_textblock  avia-builder-el-first'><h3 class='av-special-heading-tag'  itemprop=\"headline\"  >A trans-dermal patch for the treatment of chronic diseases such as diabetes.<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-k8juor33-d27298ac9c58f3bf3e1aadf9c2105b17'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/04\/patch.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-40019\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/04\/patch.png\" alt=\"\" width=\"318\" height=\"248\" \/><\/a>Glycemic control, necessary to reduce chronic complications in type 1 diabetes, often requires numerous daily injections of insulin. The discomfort associated with the use of needles often leads diabetic patients to become discouraged or even neglect their own therapeutic management.<\/p>\n<p>Today, several technological developments are underway to offer alternative solutions to (multi)daily insulin injections. Transdermal delivery of insulin, a painless and simple approach, is an interesting alternative and offers several advantages such as the possibility of prolonged treatment on demand. However, transdermal delivery of insulin is limited by the low permeability of the outermost epidermal layer (stratum corneum), which only allows the passage of hydrophobic molecules with a molecular weight below 500 Da.<\/p>\n<p>In this work*, we demonstrated the enhancement of stratum corneum permeability by thermal activation for insulin permeation. We developed a novel transdermal insulin delivery system that exploits the excellent electrothermal properties of a perforated gold thin film coated with an insulin-loaded graphene layer. By applying a low voltage (less than 200 mW cm<sup>-2<\/sup>), a stable temperature of 52\u00b0C can be reached within seconds to initiate insulin delivery. This self-powered platform can use commercially available portable battery systems. Thus, this transdermal patch, designed using a simple technology, represents an advance for the treatment of chronic diseases such as diabetes for which efficient and non-invasive insulin dosing remains a major challenge.<\/p>\n<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/nh\/c9nh00576e\"><strong>*Electrothermal patches driving the transdermal delivery of insulin <\/strong><\/a><\/p>\n<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/nh\/c9nh00576e\">Quentin Pagneux, Ran Ye, Li Chengnan, Alexandre Barras, Nathalie Hennuyer, Bart Staels, D. Caina, J. I. Avila Osses, Amar Abderrahmani, Val\u00e9rie Plaisance, Val\u00e9rie Pawlowski, Rabah Boukherroub, Sorin Melinte and Sabine Szunerits <\/a><\/p>\n<p><strong><em>Nanoscale Horizons<\/em><\/strong>, 2020, <strong>5<\/strong>, 663-670. <a href=\"https:\/\/doi.org\/10.1039\/C9NH00576E\">https:\/\/doi.org\/10.1039\/C9NH00576E<\/a><\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":40019,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,299],"tags":[300],"class_list":["post-40022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-news-2","tag-nl1"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/40022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=40022"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/40022\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/40019"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=40022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=40022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=40022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}