{"id":38648,"date":"2019-12-13T12:32:24","date_gmt":"2019-12-13T10:32:24","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=38648"},"modified":"2019-12-19T11:04:25","modified_gmt":"2019-12-19T09:04:25","slug":"capteur-aptamere-a-base-de-fet-de-graphene-et-de-loptique-plasmon","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/capteur-aptamere-a-base-de-fet-de-graphene-et-de-loptique-plasmon.html","title":{"rendered":"Soutenance de th\u00e8se : Patrik ASPERMAIR \u2013 Capteur aptam\u00e8re \u00e0 base de FET de graph\u00e8ne et de l\u2019optique plasmon"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_heading  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_58_1akxkzru4zf0c\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;border-style:solid;border-color:#000;background-position:0% 0%;background-repeat:no-repeat;width:180px;height:30px;left:0px;top:231px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-quote-right\" style=\"color:#ffffff;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>ACTUALITES<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-38648'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-k48drpag-42cc266ab8451cd9cfa386d6be014479\">\n#top .av-special-heading.av-k48drpag-42cc266ab8451cd9cfa386d6be014479{\nmargin:0 0 10px 0;\npadding-bottom:4px;\n}\nbody .av-special-heading.av-k48drpag-42cc266ab8451cd9cfa386d6be014479 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-k48drpag-42cc266ab8451cd9cfa386d6be014479 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-k48drpag-42cc266ab8451cd9cfa386d6be014479 av-special-heading-h2  avia-builder-el-1  el_after_av_layerslider  el_before_av_hr  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >THESIS: Graphene FET-based aptamer sensor and plasmon optics<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-18u73nj-dad6a947580930e400fc42ba200e80f1\">\n#top .hr.av-18u73nj-dad6a947580930e400fc42ba200e80f1{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n.hr.av-18u73nj-dad6a947580930e400fc42ba200e80f1 .hr-inner{\nwidth:100%;\n}\n<\/style>\n<div  class='hr av-18u73nj-dad6a947580930e400fc42ba200e80f1 hr-custom  avia-builder-el-2  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jriy64i8-2f4600354c0449b610997916bbd9b6bc'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" >\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13ewzjw-68e036126b913e5028f77311dc66b825\">\n.av_font_icon.av-13ewzjw-68e036126b913e5028f77311dc66b825{\ncolor:#bfbfbf;\nborder-color:#bfbfbf;\n}\n.av_font_icon.av-13ewzjw-68e036126b913e5028f77311dc66b825 .av-icon-char{\nfont-size:60px;\nline-height:60px;\n}\n<\/style>\n<span  class='av_font_icon av-13ewzjw-68e036126b913e5028f77311dc66b825 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue8c9' data-av_iconfont='entypo-fontello' ><\/span><\/span>\n<h5><strong style=\"font-size: 16px;\"><strong>Patrik ASPERMAIR<\/p>\n<p><\/strong><\/strong><\/h5>\n<p><strong>Tuesday 17 December 2019 at 10.00 am<br \/>\n<\/strong>Muthgasse 11, 2nd floor A-1190 Vienna - room A-OG02-O03<\/p>\n<\/div><\/section>\n<section  class='av_textblock_section av-jtefqx33-628129dba2299b2ecd65ebfc92eac29d'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div  class='hr av-kjh3zw-4dff888f744b728a1aca9b3a0971493a hr-default  avia-builder-el-6  avia-builder-el-no-sibling'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<h5><strong><span style=\"color: #800000;\">Jury :<\/span><\/strong><\/h5>\n<ul>\n<li>Sabine SZUNERITS, PREX, University of Lille (Supervisor)<\/li>\n<li>Vincent BOUCHIAT, Research Director, Institute N\u00e9el (Rapporteur)<\/li>\n<li>Jos\u00e9 Luis TOCA-HERRERA, Research Director, Institute of Biophysics (Rapporteur)<\/li>\n<li>Wolfgang KNOLL, Professor, Austrian Institute of Technology (supervisor)<\/li>\n<\/ul>\n<h5><span class=\"\">Summary: <\/span><\/h5>\n<p><span class=\"\">The choice between optical detection principles and electrical concepts for biomedical diagnostics has not yet been decided. Both approaches continue to offer solutions for rapid, multiplexed, simple and inexpensive detection of relevant biological molecules. However, if small analytes are to be detected and\/or if the analyte binding density at the transducer surface is low, label-free optical detection is problematic. In this work, an innovative and versatile detection platform was developed, combining an electrical and optical readout device to compare signals during real-time biological recognition. It is based on coupling the reading of a graphene-based field effect transistor (gFET) with that of surface plasmon resonance (SPR). Various types of link, including biotin\/neutravidin, PNA\/DNA and ssRNA\/ssDNA aptamer for protein detection, were studied and the results discussed.<\/span><\/p>\n<h5>Abstract:<\/h5>\n<p>The race in biomedical diagnostics between optical detection principles and electrical concepts is not decided yet. Both approaches continue to offer solutions for fast, multiplexed, simple and cheap detection of biological relevant molecules. However, if it comes to the detection of small analytes and\/or if the achievable analyte binding density at the transducer surface is low, label-free optical detection schemes have a problem because the change in the optical interfacial architecture induced by the mere binding of the analyte may be simply too minute to be detected. In this work, an innovative and versatile sensing platform, combining an electrical and optical read-out device to compare the different signal behaviours during a biological binding event in real time was developed. It is based in coupling the read out of a graphene-based field-effect transistor (gFET) with that of surface plasmon resonance (SPR). Various binding events including biotin\/neutravidin, PNA\/DNA and ssRNA\/ssDNA aptamers for protein detection were investigated and the results discussed.<\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":38653,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,36],"tags":[],"class_list":["post-38648","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-articles-temporaires"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/38648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=38648"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/38648\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/38653"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=38648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=38648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=38648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}