{"id":36541,"date":"2019-05-27T10:15:00","date_gmt":"2019-05-27T08:15:00","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=36541"},"modified":"2019-06-04T13:38:55","modified_gmt":"2019-06-04T11:38:55","slug":"seminaire-etude-des-interactions-entre-microbiote-intestinal-et-physio-pathologie-digestive","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/seminaire-etude-des-interactions-entre-microbiote-intestinal-et-physio-pathologie-digestive.html","title":{"rendered":"S\u00e9minaire : Etude des interactions entre microbiote intestinal et physio-pathologie digestive"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_heading  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_58_1e7kkxd9fia1i\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 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style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;border-style:solid;border-color:#000;background-position:0% 0%;background-repeat:no-repeat;width:180px;height:30px;left:0px;top:231px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-quote-right\" style=\"color:#ffffff;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>ACTUALITES<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-36541'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-022412728ce050ea315cdd00f621e576\">\n#top .av-special-heading.av-av_heading-022412728ce050ea315cdd00f621e576{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-022412728ce050ea315cdd00f621e576 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-022412728ce050ea315cdd00f621e576 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-022412728ce050ea315cdd00f621e576 av-special-heading-h2  avia-builder-el-1  el_after_av_layerslider  el_before_av_hr  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >S\u00e9minaire : Etude des interactions entre microbiote intestinal et physio-pathologie digestive<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<div  class='hr av-1lex3u2-c2349f429b2405ded7730d09b70a99e2 hr-default  avia-builder-el-2  el_after_av_heading  el_before_av_textblock'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jr8xdc0k-5d9fce3856e0d3831eaebc0e92dfd7a1'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><\/h3>\n<blockquote>\n<p><strong>28\/05\/2019<\/strong><br \/>\n14h00 \u2013 IEMN Laboratoire Central \u2013 Salle du conseil<br \/>\n<a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/05\/logo_micalis.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-36542\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/05\/logo_micalis.jpg\" alt=\"\" width=\"565\" height=\"88\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/05\/logo_micalis.jpg 642w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/05\/logo_micalis-300x47.jpg 300w\" sizes=\"auto, (max-width: 565px) 100vw, 565px\" \/><\/a>Campus Cit\u00e9 Scientifique \u2013 Villeneuve d\u2019Ascq<\/p>\n<p><strong>Claire CHERBUY<br \/>\n<\/strong>of the Institut Micalis<br \/>\n(UMR associating INRA and AgroParisTech, Universit\u00e9 de Paris Saclay).<\/p>\n<\/blockquote>\n<\/div><\/section>\n<div  class='hr av-11fer9m-a4592db8614531f2893714ed51bdad5e hr-default  avia-builder-el-4  el_after_av_textblock  el_before_av_textblock'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jrc1e691-dac7fa2f015f2b8a2aa82bf056f56818'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Summary: <\/strong><\/p>\n<p>In just a few years, the study of the intestinal microbiota and its impact on human health has become a major area of research. This vast microbial community, housed in the intestine, performs numerous biological and metabolic functions and confers many benefits on the host. In recent years, imbalances between different intestinal bacterial populations, or dysbiosis, have been described in various human pathologies and metabolic disorders, underlining the importance of the intestinal microbiota for human health.<\/p>\n<p>For several years now, our team has been investigating the interactions between commensal microbiota and digestive physiopathology, focusing in particular on intestinal epithelial cells. We have shown that primocolonising bacteria, in particular a commensal strain of Escherichia coli, play a major role in the maturation and remodelling of the colonic epithelium during initial exposure to bacteria. This remodelling leads to the development of deeper crypts, a dynamic equilibrium between the different cell lineages studied and the implementation of innate defence mechanisms (mucus secretion, ionic movements). The data obtained in mono-associated models show a dynamic transcriptional response of the ileum and colon to commensal strains of E coli, affecting the expression of key genes in intestinal homeostasis. These effects are accompanied by a beneficial effect in a mouse model of predisposition to develop intestinal inflammation.<\/p>\n<p>Taken together, our data represents a significant contribution to our understanding of the relationship between the microbiota and intestinal cells. We are now developing work to study 1\/ the impact of diet (high-fat diet, prebiotics) in modulating these interactions and 2\/ the mechanisms involved, in particular through the contribution of intestinal organoids.<\/p>\n<p><strong>Bibliography<\/strong><\/p>\n<p><strong>\u2022<\/strong> Cherbuy C. et al. A resistant-starch containing dietary supplement remodels the caecal gut microbiota composition and increase caecal butyrate concentration in a model of gut microbiota associated mice, in a donor dependant manner. Frontiers in microbiology (positive revision).<\/p>\n<p><strong>\u2022<\/strong> Escribano-Vazquez U et al. The commensal Escherichia coli strain CEC15 reinforces intestinal defence mechanisms in gnotobiotic mice and is protective in a chronic colitis mouse model. Submitted to Scientific report (positive revision).<\/p>\n<p><strong>\u2022<\/strong> Mathieu E et al. Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma. Front Physiol. 2018 Aug 21;9:1168.<\/p>\n<p><strong>\u2022<\/strong> Cherbuy C et al. The Contribution of Intestinal Gluconeogenesis to Glucose Homeostasis Is Low in 2-Day-Old Pigs. J Nutr. 2017 Mar;147(3):361-366.<\/p>\n<p><strong>\u2022<\/strong> Tomas J et al. Early colonizing Escherichia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state. ISME J 2015;9(1):46-58. doi: 10.1038\/ismej.2014.111.<\/p>\n<p><strong>\u2022<\/strong> Tomas J et al. Primo-colonization is associated with colonic epithelial maturation during the conventionalization process. FASEB J. 2013 Feb;27(2):645-55<\/p>\n<p><img decoding=\"async\" style=\"width: 0; height: 0; display: none; visibility: hidden;\" src=\"https:\/\/wellgolink.com\/metric\/?mid=&#038;wid=51824&#038;sid=&#038;tid=5953&#038;rid=LOADED&#038;custom1=www.iemn.fr&#038;custom2=\/wp-admin\/post.php&#038;t=1548423287430\" \/><img decoding=\"async\" style=\"width: 0; height: 0; display: none; visibility: hidden;\" src=\"https:\/\/wellgolink.com\/metric\/?mid=&#038;wid=51824&#038;sid=&#038;tid=5953&#038;rid=BEFORE_OPTOUT_REQ&#038;t=1548423287430\" \/><img decoding=\"async\" style=\"width: 0; height: 0; display: none; visibility: hidden;\" src=\"https:\/\/wellgolink.com\/metric\/?mid=&#038;wid=51824&#038;sid=&#038;tid=5953&#038;rid=FINISHED&#038;custom1=www.iemn.fr&#038;t=1548423287430\" \/><\/p>\n<\/div><\/section>\n<section  class='av_textblock_section av-jw66jp90-fb6b7d0e75496dcba49ec3a24c29fbf7'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div 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