{"id":36419,"date":"2019-04-24T08:31:39","date_gmt":"2019-04-24T06:31:39","guid":{"rendered":"https:\/\/www.iemn.fr\/?p=36419"},"modified":"2019-09-06T10:26:45","modified_gmt":"2019-09-06T08:26:45","slug":"36419","status":"publish","type":"post","link":"https:\/\/www.iemn.fr\/en\/actualites\/36419.html","title":{"rendered":"Soutenance de th\u00e8se de Damien ESCHIMESE : Conception, fabrication et caract\u00e9risation de sondes de spectroscopie raman \u00e0 exaltation de pointe \u00e0 base de nano-antennes m\u00e9talliques"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_heading  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_58_smkisizndjfv\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/01\/sliders_news1-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;border-style:solid;border-color:#000;background-position:0% 0%;background-repeat:no-repeat;width:180px;height:30px;left:0px;top:231px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-quote-right\" style=\"color:#ffffff;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>ACTUALITES<\/ls-layer><\/div><\/div><\/div><div id='after_layer_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-36419'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-1b0ed359b5de8039e471bc9bdc62ae79\">\n#top .av-special-heading.av-av_heading-1b0ed359b5de8039e471bc9bdc62ae79{\nmargin:0 0 10px 0;\npadding-bottom:4px;\n}\nbody .av-special-heading.av-av_heading-1b0ed359b5de8039e471bc9bdc62ae79 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-1b0ed359b5de8039e471bc9bdc62ae79 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-1b0ed359b5de8039e471bc9bdc62ae79 av-special-heading-h2  avia-builder-el-1  el_after_av_layerslider  el_before_av_hr  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >THESIS: Development of a microsystem integrating microfluidic functions for the biophysical characterisation of single cancer cells<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-18u73nj-dad6a947580930e400fc42ba200e80f1\">\n#top .hr.av-18u73nj-dad6a947580930e400fc42ba200e80f1{\nmargin-top:5px;\nmargin-bottom:5px;\n}\n.hr.av-18u73nj-dad6a947580930e400fc42ba200e80f1 .hr-inner{\nwidth:100%;\n}\n<\/style>\n<div  class='hr av-18u73nj-dad6a947580930e400fc42ba200e80f1 hr-custom  avia-builder-el-2  el_after_av_heading  el_before_av_textblock  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-thin'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-jriy64i8-2f4600354c0449b610997916bbd9b6bc'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" >\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13ewzjw-68e036126b913e5028f77311dc66b825\">\n.av_font_icon.av-13ewzjw-68e036126b913e5028f77311dc66b825{\ncolor:#bfbfbf;\nborder-color:#bfbfbf;\n}\n.av_font_icon.av-13ewzjw-68e036126b913e5028f77311dc66b825 .av-icon-char{\nfont-size:60px;\nline-height:60px;\n}\n<\/style>\n<span  class='av_font_icon av-13ewzjw-68e036126b913e5028f77311dc66b825 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue8c9' data-av_iconfont='entypo-fontello' ><\/span><\/span>\n<h5><strong style=\"font-size: 16px;\">Damien ESCHIMESE<\/strong><\/h5>\n<p><strong>Friday 03 May 2019 at 2.00 pm<br \/>\n<\/strong>Amphitheatre of the IEMN-Laboratoire central - Villeneuve d'Ascq<\/p>\n<\/div><\/section>\n<section  class='av_textblock_section av-jtefqx33-628129dba2299b2ecd65ebfc92eac29d'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div  class='hr av-kjh3zw-4dff888f744b728a1aca9b3a0971493a hr-default  avia-builder-el-6  avia-builder-el-no-sibling'><span class='hr-inner'><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<h5><strong><span style=\"color: #800000;\">Jury:<\/span><\/strong><\/h5>\n<table>\n<tbody>\n<tr>\n<td>Fr\u00e9d\u00e9rique DE FORNEL<\/td>\n<td><\/td>\n<td>Research Director<\/td>\n<td><\/td>\n<td>University of Burgundy<\/td>\n<td><\/td>\n<td>Rapporteur<\/td>\n<\/tr>\n<tr>\n<td>C\u00e9dric AYELA<\/td>\n<td><\/td>\n<td>Research Manager<\/td>\n<td><\/td>\n<td>Bordeaux Laboratory for Material and System Integration<\/td>\n<td><\/td>\n<td>Rapporteur<\/td>\n<\/tr>\n<tr>\n<td>Thierry MELIN<\/td>\n<td><\/td>\n<td>Research Director<\/td>\n<td><\/td>\n<td>Institute of Electronics, Microelectronics and Nanotechnology<\/td>\n<td><\/td>\n<td>Directeur de th\u00e8se<\/td>\n<\/tr>\n<tr>\n<td>Stephen ARSCOTT<\/td>\n<td><\/td>\n<td>Research Director<\/td>\n<td><\/td>\n<td>Institute of Electronics, Microelectronics and Nanotechnology<\/td>\n<td><\/td>\n<td>Thesis Co-Director<\/td>\n<\/tr>\n<tr>\n<td>Ga\u00ebtan L\u00c9V\u00caQUE<\/td>\n<td><\/td>\n<td>Senior Lecturer<\/td>\n<td><\/td>\n<td>University of Lille - IEMN<\/td>\n<td><\/td>\n<td>Examinateur<\/td>\n<\/tr>\n<tr>\n<td>Anne-Laure BAUDRION<\/td>\n<td><\/td>\n<td>Senior Lecturer<\/td>\n<td><\/td>\n<td>Troyes University of Technology, L2n<\/td>\n<td><\/td>\n<td>Examinateur<\/td>\n<\/tr>\n<tr>\n<td>Bernard HUMBERT<\/td>\n<td><\/td>\n<td>Professeur des Universit\u00e9s<\/td>\n<td><\/td>\n<td>Jean Rouxel Materials Institute, Nantes<\/td>\n<td><\/td>\n<td>Examinateur<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span class=\"\">Summary:<\/span><\/h5>\n<p>As tumour masses develop, cancer cells acquire a specific phenotype that makes them resistant to treatment and enables them to invade surrounding tissues, the peripheral bloodstream and spread throughout the body. Surgical treatment of primary tumours is mostly effective, but targeting tumour cells spread to distant organs remains extremely complex. As a result, ~90 % of cancer-related mortality is due to tumour development at secondary sites: metastases. The change in the phenotype of the cell required for metastatic progression is also accompanied by a significant reduction in its rigidity, enabling it to insert itself into the surrounding tissues. As a result, the characterisation of biomechanical properties may prove to be an original approach for detecting cancer cells in the bloodstream (circulating tumour cells).<\/p>\n<div id=\"attachment_34929\" style=\"width: 523px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-34929\" class=\"wp-image-34929\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2.jpg\" alt=\"\" width=\"513\" height=\"261\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2.jpg 1044w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2-300x153.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2-768x391.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2-1030x524.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2019\/03\/YT_img2-705x359.jpg 705w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><\/a><p id=\"caption-attachment-34929\" class=\"wp-caption-text\">Overview of the on-chip measurement system for cellular mechanical characteristics<\/p><\/div>\n<p>Recurrently, the various techniques are exposed to a compromise between the characterisation throughput (number of cells processed in a given time) and its content (number and precision of parameters measured). Some techniques, such as atomic force microscopy (AFM), enable very precise measurements but suffer from an extremely low characterisation throughput, while methods based on microfluidics, similar to flow deformability cytometry, enable interesting measurement throughputs but suffer from a lack of content, making it impossible to precisely identify the different cell phenotypes.<\/p>\n<p>Circulating cells are micron-sized (10-30 microns in diameter), so microtechnologies offer multiple dimensional advantages for manipulating, stimulating and characterising them individually. MEMS (Micro Electro Mechanical Systems) are therefore ideally suited to measuring the various biophysical parameters and mechanical and electrical properties of single cells. However, MEMS devices cannot be used in a conductive liquid environment for electrical and mechanical characterisation. To overcome this limitation, this study proposes to separate the part that manipulates the cell in its biological environment from the MEMS actuators and sensors that perform the electrical and mechanical measurements. In addition, to increase the characterisation throughput and ensure operability, the MEMS device directly integrates the microfluidic channel in which the cells will circulate.<\/p>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":36425,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36419","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/36419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=36419"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/posts\/36419\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media\/36425"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=36419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/categories?post=36419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/tags?post=36419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}