{"id":71545,"date":"2024-11-22T10:37:55","date_gmt":"2024-11-22T08:37:55","guid":{"rendered":"https:\/\/www.iemn.fr\/?page_id=71545"},"modified":"2024-11-22T17:31:24","modified_gmt":"2024-11-22T15:31:24","slug":"dnastrix","status":"publish","type":"page","link":"https:\/\/www.iemn.fr\/en\/les-collaborations\/projets-collaboratifs\/dnastrix","title":{"rendered":"ANR project"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-obgwup-e849561b42eb2866e0aa5229228349dd\">\n.flex_column.av-obgwup-e849561b42eb2866e0aa5229228349dd{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-obgwup-e849561b42eb2866e0aa5229228349dd av_one_full  avia-builder-el-0  el_before_av_one_full  avia-builder-el-first  first flex_column_div av-zero-column-padding'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb\">\n.avia-image-container.av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-53098 avia-img-lazy-loading-not-53098 avia_image' src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/06\/logo_anr.jpg\" alt='' title='logo_anr'  height=\"85\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/06\/logo_anr.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/06\/logo_anr-18x5.jpg 18w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l48hejsx-e4793490ff2a2a809d51b2d1d36f4496\">\n.flex_column.av-l48hejsx-e4793490ff2a2a809d51b2d1d36f4496{\nborder-radius:20px 20px 20px 20px;\npadding:10px 10px 10px 10px;\nbackground-color:#ebb401;\n}\n<\/style>\n<div  class='flex_column av-l48hejsx-e4793490ff2a2a809d51b2d1d36f4496 av_one_full  avia-builder-el-2  el_after_av_one_full  el_before_av_one_full  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48hdtga-50380e38c85ad2e1915c9650e85ebb6d'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Project <strong><span style=\"caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;\">ANR-24-CE30-1443<\/span><span style=\"caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;\">&nbsp;<\/span><\/strong><\/h3>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lkgiy9-6fe9252508a87bef590816866096ff99\">\n.flex_column.av-lkgiy9-6fe9252508a87bef590816866096ff99{\nborder-radius:0px 0px 0px 0px;\npadding:20px 0px 20px 0px;\n}\n<\/style>\n<div  class='flex_column av-lkgiy9-6fe9252508a87bef590816866096ff99 av_one_full  avia-builder-el-4  el_after_av_one_full  el_before_av_textblock  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48g5n3e-1551bed9ef7e820e4f83d8e2482ed0e9'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8\">\n.av_font_icon.av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8{\ncolor:#ebb401;\nborder-color:#ebb401;\n}\n.av_font_icon.av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span>DNASTRIX<\/h4>\n<h4><\/h4>\n<\/div><\/section><\/div><\/p>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l48g64e5-ff59cec83eb92ca4253e1d2739a34413\">\n#top .av_textblock_section.av-l48g64e5-ff59cec83eb92ca4253e1d2739a34413 .avia_textblock{\nfont-size:14px;\n}\n<\/style>\n<section  class='av_textblock_section av-l48g64e5-ff59cec83eb92ca4253e1d2739a34413'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><ul>\n<li><strong>R\u00e9sum\u00e9 en Fran\u00e7ais<\/strong>:<\/li>\n<\/ul>\n<p>Tissue cells are affected by mechanical forces at different lengths and timescales, and these intracellular and extracellular mechanical signals affect the evolution of cell life. However, although the mechanics of the cell as a whole is now a fairly well-studied subject, we still lack a detailed understanding of the mechanisms by which these mechanical stresses are transmitted to the nucleus of the cell, and what the effects of mechanical deformation are on nuclear processes, involving the (re)organisation of chromatin and possibly downstream genetic functions associated with DNA.The DNASTRIX project aims to study and quantify how nuclear mechanics can be modified by forces from the cellular environment, and what are the key genomic implications of these mechanical processes, from the cellular to the molecular scale, potentially involved in many human diseases. To achieve such ambitious goals, we will push the boundaries of a set of innovative techniques based on micro-electro-mechanical systems (MEMS) devices, under active development in our laboratories, by which we can apply controlled forces to both molecular aggregates, and whole living cells, while performing real-time fluorescence and confocal imaging. In parallel, we will exploit a theoretical and computational molecular dynamics modelling programme (atomic and coarse-grained) of the key proteins involved in the mechanical actions transmitted to chromatin, as well as micromechanical modelling of whole cells, to elucidate the multi-scale details of the transfer of mechanical stresses to nuclear constituents. The objectives of this project are therefore twofold and parallel: (1) to observe and quantify the link between extranuclear cellular structures and the nucleus; (2) to reorganise chromatin and identify possible damage to chromatin and DNA induced by mechanical forces.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-71549\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix.jpg\" alt=\"\" width=\"450\" height=\"309\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix.jpg 850w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-300x206.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-768x527.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-18x12.jpg 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-845x583.jpg 845w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-705x484.jpg 705w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n<ul>\n<li>\n<h4><strong>R\u00e9sum\u00e9 en Anglais<\/strong>:<\/h4>\n<\/li>\n<\/ul>\n<p>Tissue cells are affected by mechanical forces at different lengths and timescales, and these intracellular and extracellular mechanical signals affect the evolution of cell life. However, although the mechanics of the cell as a whole is now a fairly well-studied subject, we still lack a detailed understanding of the mechanisms by which these mechanical stresses are transmitted to the nucleus of the cell, and what the effects of mechanical deformation are on nuclear processes, involving the (re)organisation of chromatin and possibly downstream genetic functions associated with DNA. The DNASTRIX project aims to study and quantify how nuclear mechanics can be modified by forces from the cellular environment, and what are the key genomic implications of these mechanical processes, from the cellular to the molecular scale, potentially involved in many human diseases. To achieve such ambitious goals, we will push the boundaries of a set of innovative techniques based on micro-electro-mechanical systems (MEMS) devices, under active development in our laboratories, by which we can apply controlled forces to both molecular aggregates, and whole living cells, while performing real-time fluorescence and confocal imaging. In parallel, we will exploit a theoretical and computational molecular dynamics modelling programme (atomic and coarse-grained) of the key proteins involved in the mechanical actions transmitted to chromatin, as well as micromechanical modelling of whole cells, to elucidate the multi-scale details of the transfer of mechanical stresses to nuclear constituents. The objectives of this project are therefore twofold and parallel: (1) to observe and quantify the link between extranuclear cellular structures and the nucleus; (2) to reorganise chromatin and identify possible damage to chromatin and DNA induced by mechanical forces.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-71549 aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix.jpg\" alt=\"\" width=\"450\" height=\"309\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix.jpg 850w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-300x206.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-768x527.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-18x12.jpg 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-845x583.jpg 845w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/visual_dnastrix-705x484.jpg 705w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lkgiy9-14-2c8e0944eee09df78e71b202fe4921e9\">\n.flex_column.av-lkgiy9-14-2c8e0944eee09df78e71b202fe4921e9{\nborder-radius:0px 0px 0px 0px;\npadding:20px 0px 20px 0px;\n}\n<\/style>\n<div  class='flex_column av-lkgiy9-14-2c8e0944eee09df78e71b202fe4921e9 av_one_full  avia-builder-el-8  el_after_av_textblock  el_before_av_one_half  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48g5n3e-13-7278ea6f22ac0f17c9a39b622a792934'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-12-19d76c9397e1e1dc6fbb7ab860934b8e\">\n.av_font_icon.av-mqde7m-12-19d76c9397e1e1dc6fbb7ab860934b8e{\ncolor:#ebb401;\nborder-color:#ebb401;\n}\n.av_font_icon.av-mqde7m-12-19d76c9397e1e1dc6fbb7ab860934b8e .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-12-19d76c9397e1e1dc6fbb7ab860934b8e avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span>Partners<\/h4>\n<h5><\/h5>\n<\/div><\/section><\/div>\n<div class='flex_column_table av-237o9w1-e31f98e4cf06d668c03c0d3978576c28 sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-e31f98e4cf06d668c03c0d3978576c28\">\n@keyframes av_boxShadowEffect_av-237o9w1-e31f98e4cf06d668c03c0d3978576c28-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-e31f98e4cf06d668c03c0d3978576c28{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-e31f98e4cf06d668c03c0d3978576c28 av_one_half  avia-builder-el-11  el_after_av_one_full  el_before_av_one_half  first flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><section  class='av_textblock_section av-l48gdxv4-2ae09003fd94017ae2e0fee6578cc2d3'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-42329\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def-300x110.jpg\" alt=\"\" width=\"300\" height=\"110\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def-300x110.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def.jpg 340w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/h4>\n<h4><strong>Institut d\u2019Electronique, de Micro\u00e9lectronique et de Nanotechnologie, IEMN<\/strong><\/h4>\n<h5><em>Coordinateur\u00a0: Xavier Wallart<\/em><\/h5>\n<\/div><\/section><\/div>\n<div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-8-bceab16b09378dddf385b9f59d2c2d9b\">\n@keyframes av_boxShadowEffect_av-237o9w1-8-bceab16b09378dddf385b9f59d2c2d9b-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; 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Autoclose: 1 -->\n<div class='flex_column_table av-237o9w1-6-f483b9cccd268e01a9024b30325cfe76 sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-6-f483b9cccd268e01a9024b30325cfe76\">\n@keyframes av_boxShadowEffect_av-237o9w1-6-f483b9cccd268e01a9024b30325cfe76-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-6-f483b9cccd268e01a9024b30325cfe76{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-6-f483b9cccd268e01a9024b30325cfe76 av_one_half  avia-builder-el-15  el_after_av_one_half  el_before_av_one_half  first flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><section  class='av_textblock_section av-l48gdxv4-5-0dce5fa2f37a61ea57680eb98ce66769'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/canther.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-71558 aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/canther.jpg\" alt=\"\" width=\"391\" height=\"91\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/canther.jpg 391w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/canther-300x70.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/11\/canther-18x4.jpg 18w\" sizes=\"auto, (max-width: 391px) 100vw, 391px\" \/><\/a><\/p>\n<\/div><\/section><\/div>\n<div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-4-a09535fdedbbab9c129b7348b1396f8b\">\n@keyframes av_boxShadowEffect_av-237o9w1-4-a09535fdedbbab9c129b7348b1396f8b-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-4-a09535fdedbbab9c129b7348b1396f8b{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-4-a09535fdedbbab9c129b7348b1396f8b av_one_half  avia-builder-el-17  el_after_av_one_half  el_before_av_one_full  flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><\/div><\/div><!--close column table wrapper. Autoclose: 1 -->\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lkgiy9-11-e733f3040143fc6ad9c0b5db21c9fa85\">\n.flex_column.av-lkgiy9-11-e733f3040143fc6ad9c0b5db21c9fa85{\nborder-radius:0px 0px 0px 0px;\npadding:20px 0px 20px 0px;\n}\n<\/style>\n<div  class='flex_column av-lkgiy9-11-e733f3040143fc6ad9c0b5db21c9fa85 av_one_full  avia-builder-el-18  el_after_av_one_half  el_before_av_sidebar  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48g5n3e-10-1d04f8394d31e5beef5dfecb9576e8b4'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-9-db4a5443f0015cea75d606b6bcd5efee\">\n.av_font_icon.av-mqde7m-9-db4a5443f0015cea75d606b6bcd5efee{\ncolor:#ebb401;\nborder-color:#ebb401;\n}\n.av_font_icon.av-mqde7m-9-db4a5443f0015cea75d606b6bcd5efee .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-9-db4a5443f0015cea75d606b6bcd5efee avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue826' data-av_iconfont='entypo-fontello' ><\/span><\/span><a href=\"https:\/\/haltools.archives-ouvertes.fr\/Public\/afficheRequetePubli.php?projet_anr=109472&#038;CB_auteur=oui&#038;CB_titre=oui&#038;CB_identifiant=oui&#038;CB_article=oui&#038;CB_vignette=oui&#038;langue=Anglais&#038;tri_exp=annee_publi&#038;tri_exp2=typdoc&#038;tri_exp3=date_publi&#038;ordre_aff=TA&#038;CB_rubriqueDiv=oui&#038;Fen=Aff&#038;css=..\/css\/VisuRubriqueEncadre.css\" target=\"_blank\" rel=\"noopener\"> Discover all DNASTRIX project publications<\/a><\/h4>\n<h4>DNASTRIX<\/h4>\n<h5><\/h5>\n<\/div><\/section><\/div>\n<div  class='avia-builder-widget-area clearfix  avia-builder-el-21  el_after_av_one_full  avia-builder-el-last'><div id=\"hal-plus-publications-20\" class=\"widget clearfix wphal-plus-publications\"><h3 class=\"widgettitle\">Recently published by partner IEMN<\/h3><ul class=\"widhal-ul\"><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-05176171v1\" target=\"_blank\" rel=\"noopener\">Supercooling droplets on environmentally-friendly biomimetic anti-icing surfaces<\/a><\/li><\/ul><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":0,"parent":143,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-71545","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/71545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=71545"}],"version-history":[{"count":0,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/71545\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/143"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=71545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}