{"id":55124,"date":"2022-09-09T08:44:15","date_gmt":"2022-09-09T06:44:15","guid":{"rendered":"https:\/\/www.iemn.fr\/?page_id=55124"},"modified":"2025-05-20T10:07:05","modified_gmt":"2025-05-20T08:07:05","slug":"anr-nanomic","status":"publish","type":"page","link":"https:\/\/www.iemn.fr\/en\/anr-nanomic","title":{"rendered":"Projet ANR NANOMIC"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-obgwup-e849561b42eb2866e0aa5229228349dd\">\n.flex_column.av-obgwup-e849561b42eb2866e0aa5229228349dd{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-obgwup-e849561b42eb2866e0aa5229228349dd av_one_third  avia-builder-el-0  el_before_av_one_third  avia-builder-el-first  first flex_column_div av-zero-column-padding'     ><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-obgwup-13-ddfa5e3a6021867e252fa2e1d283af8b\">\n.flex_column.av-obgwup-13-ddfa5e3a6021867e252fa2e1d283af8b{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-obgwup-13-ddfa5e3a6021867e252fa2e1d283af8b av_one_third  avia-builder-el-1  el_after_av_one_third  el_before_av_one_third  flex_column_div av-zero-column-padding'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb\">\n.avia-image-container.av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-l48hjacc-51f1c3abb998a01ce275ef5054d6adcb av-styling- avia-align-center  avia-builder-el-2  avia-builder-el-no-sibling'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-53098 avia-img-lazy-loading-not-53098 avia_image' src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/06\/logo_anr.jpg\" alt='' title='logo_anr'  height=\"85\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/06\/logo_anr.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/06\/logo_anr-18x5.jpg 18w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-obgwup-12-aafefada72b62fbdec152f43fe69b335\">\n.flex_column.av-obgwup-12-aafefada72b62fbdec152f43fe69b335{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-obgwup-12-aafefada72b62fbdec152f43fe69b335 av_one_third  avia-builder-el-3  el_after_av_one_third  el_before_av_one_full  flex_column_div av-zero-column-padding'     ><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l48hejsx-e4793490ff2a2a809d51b2d1d36f4496\">\n.flex_column.av-l48hejsx-e4793490ff2a2a809d51b2d1d36f4496{\nborder-radius:20px 20px 20px 20px;\npadding:10px 10px 10px 10px;\nbackground-color:#ebb401;\n}\n<\/style>\n<div  class='flex_column av-l48hejsx-e4793490ff2a2a809d51b2d1d36f4496 av_one_full  avia-builder-el-4  el_after_av_one_third  el_before_av_one_full  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48hdtga-55abfa5656db44fdd76b37aed52962f6'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Project NANOMIC ANR-22-CE09-0016-01<\/h3>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lkgiy9-6fe9252508a87bef590816866096ff99\">\n.flex_column.av-lkgiy9-6fe9252508a87bef590816866096ff99{\nborder-radius:0px 0px 0px 0px;\npadding:20px 0px 20px 0px;\n}\n<\/style>\n<div  class='flex_column av-lkgiy9-6fe9252508a87bef590816866096ff99 av_one_full  avia-builder-el-6  el_after_av_one_full  el_before_av_one_full  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48g5n3e-d14dff6097a6073ddf6a61e5992886d8'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8\">\n.av_font_icon.av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8{\ncolor:#ebb401;\nborder-color:#ebb401;\n}\n.av_font_icon.av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-b8f4c22e6bbeb9225144fbb1e9b8c6d8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span>NANOMIC<\/h4>\n<h5><\/h5>\n<h5 class=\"translation-block\"><span id=\"page133R_mcid13\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">NANO platform<\/span> <span dir=\"ltr\" role=\"presentation\">innovative transport of<\/span> <span dir=\"ltr\" role=\"presentation\">nanobodies and manganese for tracking and<\/span> <span dir=\"ltr\" role=\"presentation\">specific magnetic resonance imaging<\/span><span dir=\"ltr\" role=\"presentation\">of pancreatic beta cells<\/span><\/span><\/h5>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lkgiy9-11-e733f3040143fc6ad9c0b5db21c9fa85\">\n.flex_column.av-lkgiy9-11-e733f3040143fc6ad9c0b5db21c9fa85{\nborder-radius:0px 0px 0px 0px;\npadding:20px 0px 20px 0px;\n}\n<\/style>\n<div  class='flex_column av-lkgiy9-11-e733f3040143fc6ad9c0b5db21c9fa85 av_one_full  avia-builder-el-9  el_after_av_one_full  el_before_av_one_fourth  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-l48g5n3e-10-f123be668bfa1041a5b045bc8469811f'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-9-ba3319396eed72cd5acaa8015aeeda90\">\n.av_font_icon.av-mqde7m-9-ba3319396eed72cd5acaa8015aeeda90{\ncolor:#ebb401;\nborder-color:#ebb401;\n}\n.av_font_icon.av-mqde7m-9-ba3319396eed72cd5acaa8015aeeda90 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-9-ba3319396eed72cd5acaa8015aeeda90 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue889' data-av_iconfont='entypo-fontello' ><\/span><\/span>Partners<\/h4>\n<h5><\/h5>\n<\/div><\/section><\/div>\n<div class='flex_column_table av-237o9w1-e31f98e4cf06d668c03c0d3978576c28 sc-av_one_fourth av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-e31f98e4cf06d668c03c0d3978576c28\">\n@keyframes av_boxShadowEffect_av-237o9w1-e31f98e4cf06d668c03c0d3978576c28-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-e31f98e4cf06d668c03c0d3978576c28{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-e31f98e4cf06d668c03c0d3978576c28 av_one_fourth  avia-builder-el-12  el_after_av_one_full  el_before_av_one_fourth  first flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><section  class='av_textblock_section av-l48gdxv4-2ae09003fd94017ae2e0fee6578cc2d3'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-42329 aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def-300x110.jpg\" alt=\"\" width=\"270\" height=\"99\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def-300x110.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/09\/logo_iemn_def.jpg 340w\" sizes=\"auto, (max-width: 270px) 100vw, 270px\" \/><\/a><\/p>\n<h4><\/h4>\n<h5 style=\"text-align: center;\"><strong>Institut d\u2019Electronique, de Micro\u00e9lectronique et de Nanotechnologie, IEMN, Lille<br \/>\n<\/strong><\/h5>\n<h6 style=\"text-align: center;\"><em>Coordinator: <span id=\"page133R_mcid14\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Amar<\/span> <span dir=\"ltr\" role=\"presentation\">ABDERRAHMANI<\/span><\/span><br \/>\n<\/em><\/h6>\n<\/div><\/section><\/div>\n<div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-7-daa7d18e52990ddabfbb1ba263a3db47\">\n@keyframes av_boxShadowEffect_av-237o9w1-7-daa7d18e52990ddabfbb1ba263a3db47-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-7-daa7d18e52990ddabfbb1ba263a3db47{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-7-daa7d18e52990ddabfbb1ba263a3db47 av_one_fourth  avia-builder-el-14  el_after_av_one_fourth  el_before_av_one_fourth  flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><section  class='av_textblock_section av-l48gdxv4-6-db0b8cb975dc001e54f13c2117353088'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/IPHC.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-55128 aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/IPHC.jpg\" alt=\"\" width=\"127\" height=\"88\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/IPHC.jpg 240w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/IPHC-18x12.jpg 18w\" sizes=\"auto, (max-width: 127px) 100vw, 127px\" \/><\/a><\/p>\n<h5 style=\"text-align: center;\"><strong>Institut Pluridisciplinaire Hubert Curien, IPHC, Strasbourg<\/strong><\/h5>\n<\/div><\/section><\/div>\n<div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-5-26f213818988b268221fb38f08449172\">\n@keyframes av_boxShadowEffect_av-237o9w1-5-26f213818988b268221fb38f08449172-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-5-26f213818988b268221fb38f08449172{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-5-26f213818988b268221fb38f08449172 av_one_fourth  avia-builder-el-16  el_after_av_one_fourth  el_before_av_one_fourth  flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><section  class='av_textblock_section av-l48gdxv4-4-dc12037282c0b744492ffe59e6b5db3c'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/LISM.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55129\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/LISM.png\" alt=\"\" width=\"405\" height=\"99\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/LISM.png 454w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/LISM-300x73.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/LISM-18x4.png 18w\" sizes=\"auto, (max-width: 405px) 100vw, 405px\" \/><\/a><\/p>\n<h5 style=\"text-align: center;\"><strong>Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires, LISM, Marseille<\/strong><\/h5>\n<\/div><\/section><\/div>\n<div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-237o9w1-3-519f8a0ea3eae1211985a9aec7ee5c6f\">\n@keyframes av_boxShadowEffect_av-237o9w1-3-519f8a0ea3eae1211985a9aec7ee5c6f-column {\n0%   { box-shadow:  0 0 0 0 #d3d3d3; opacity: 1; }\n100% { box-shadow:  0 0 10px 0 #d3d3d3; opacity: 1; }\n}\n.flex_column.av-237o9w1-3-519f8a0ea3eae1211985a9aec7ee5c6f{\nbox-shadow: 0 0 10px 0 #d3d3d3;\nborder-width:2px;\nborder-color:#cccccc;\nborder-style:solid;\nborder-radius:10px 10px 10px 10px;\npadding:20px 20px 20px 20px;\n}\n<\/style>\n<div  class='flex_column av-237o9w1-3-519f8a0ea3eae1211985a9aec7ee5c6f av_one_fourth  avia-builder-el-18  el_after_av_one_fourth  el_before_av_textblock  flex_column_table_cell av-equal-height-column av-align-bottom shadow-not-animated  column-top-margin'     ><section  class='av_textblock_section av-l48gdxv4-2-ee4d12b217d6d66e8ea4ab0ec5365530'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/logo-CBM.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-55130 aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/logo-CBM.jpg\" alt=\"\" width=\"74\" height=\"114\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/logo-CBM.jpg 181w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/11\/logo-CBM-8x12.jpg 8w\" sizes=\"auto, (max-width: 74px) 100vw, 74px\" \/><\/a><\/p>\n<h5 style=\"text-align: center;\"><strong>Centre de Biophysique Mol\u00e9culaire, CBM, Orl\u00e9ans<\/strong><\/h5>\n<\/div><\/section><\/div><\/div><!--close column table wrapper. Autoclose: 1 -->\n<section  class='av_textblock_section av-l48g64e5-b1c6fc41ede5d9ffe50c71bec5ec6310'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><ul>\n<li><strong><span style=\"color: #800000;\">IEMN Project Sponsor:<\/span> <span id=\"page133R_mcid14\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Amar<\/span> <span dir=\"ltr\" role=\"presentation\">ABDERRAHMANI<\/span><\/span><br \/>\n<\/strong><\/li>\n<li><strong><span style=\"color: #800000;\">Coordinator:<\/span> IEMN<br \/>\n<\/strong><\/li>\n<li><strong><span style=\"color: #800000;\">Partners:<\/span> LISM, IPHC, CBM<br \/>\n<\/strong><\/li>\n<\/ul>\n<p><strong><u>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13ewzjw-b58072c982babce8ed7840ecc9331fc9\">\n.av_font_icon.av-13ewzjw-b58072c982babce8ed7840ecc9331fc9{\ncolor:#800000;\nborder-color:#800000;\n}\n.av_font_icon.av-13ewzjw-b58072c982babce8ed7840ecc9331fc9 .av-icon-char{\nfont-size:20px;\nline-height:20px;\n}\n<\/style>\n<span  class='av_font_icon av-13ewzjw-b58072c982babce8ed7840ecc9331fc9 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue885' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/u><span style=\"color: #800000;\">Context:<\/span><\/strong><\/p>\n<p>Visualizing beta cells and quantifying their number by MRI an unmet medical need!<\/p>\n<p>\u2013 Beta cells are the predominant cell type of the pancreatic islets of Langerhans, which are composed of 5 different types<br \/>\n\u2013 Beta cells produce insulin, the only hormone that lower glycemia<br \/>\n\u2013 Loss of beta cell mass (BCM) mainly caused by cell death causes type 1 diabetes (only 10 to 50% BCM remaining at disease diagnosis). In type 2 diabetes beta cell function deteriorates but a progressive decline of BCM 30 to 50% in long term disease ensues over<br \/>\nyears.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55622\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals.jpg\" alt=\"\" width=\"317\" height=\"69\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals.jpg 1552w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-300x66.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-1030x225.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-768x168.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-1536x336.jpg 1536w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-18x4.jpg 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-1500x328.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-goals-705x154.jpg 705w\" sizes=\"auto, (max-width: 317px) 100vw, 317px\" \/><\/p>\n<p><strong><u>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13ewzjw-1-e11450bf8827f3333a846a73dfbf080f\">\n.av_font_icon.av-13ewzjw-1-e11450bf8827f3333a846a73dfbf080f{\ncolor:#800000;\nborder-color:#800000;\n}\n.av_font_icon.av-13ewzjw-1-e11450bf8827f3333a846a73dfbf080f .av-icon-char{\nfont-size:20px;\nline-height:20px;\n}\n<\/style>\n<span  class='av_font_icon av-13ewzjw-1-e11450bf8827f3333a846a73dfbf080f avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue885' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/u><span style=\"color: #800000;\">Objectives:<\/span><\/strong><\/p>\n<p>To engineer a disruptive nanoparticle based Magnetic Resonance Imaging (MRI) platform specifically targeting beta cells<\/p>\n<p>\u2013 For a relative accurate quantification of the number of beta cells in normal islets (the number will be compared to this determined by the immunohistochemistry method, the gold standard quantification of BCM)<br \/>\n\u2013 For a sensitive quantification of the number of beta cells when they slightly increase or decrease in diabetes<\/p>\n<p>Thus, the <strong>NANOMIC<\/strong> project aims at creating an innovative nanobody targeted NANOplatform delivering manganese contrast agents for MRI visualization of pancreatic Islet beta Cells.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-55625 aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives.jpg\" alt=\"\" width=\"349\" height=\"249\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives.jpg 1546w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-300x214.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-1030x736.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-768x548.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-1536x1097.jpg 1536w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-18x12.jpg 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-1500x1071.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-260x185.jpg 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2022\/12\/nanomic-objectives-705x503.jpg 705w\" sizes=\"auto, (max-width: 349px) 100vw, 349px\" \/><\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-uqruyc-52477bdb907b9bc82c96724f48575bae\">\n.flex_column.av-uqruyc-52477bdb907b9bc82c96724f48575bae{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-uqruyc-52477bdb907b9bc82c96724f48575bae av_one_full  avia-builder-el-23  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><section  class='av_textblock_section av-lmj8l5o9-d52422f870683d9b2cf91602a4ac6a89'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-8-bd8036e5790087e43988a433ee7e7783\">\n.av_font_icon.av-mqde7m-8-bd8036e5790087e43988a433ee7e7783{\ncolor:#ebb401;\nborder-color:#ebb401;\n}\n.av_font_icon.av-mqde7m-8-bd8036e5790087e43988a433ee7e7783 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-8-bd8036e5790087e43988a433ee7e7783 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue826' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/h4>\n<h4><a href=\"https:\/\/haltools.archives-ouvertes.fr\/Public\/afficheRequetePubli.php?projet_anr=66713&amp;CB_auteur=oui&amp;CB_titre=oui&amp;CB_identifiant=oui&amp;CB_article=oui&amp;CB_vignette=oui&amp;langue=Anglais&amp;tri_exp=annee_publi&amp;tri_exp2=typdoc&amp;tri_exp3=date_publi&amp;ordre_aff=TA&amp;CB_rubriqueDiv=oui&amp;Fen=Aff&amp;css=..\/css\/VisuRubriqueEncadre.css\" target=\"_blank\" rel=\"noopener\"><u>Discover all NANOMIC project publications<\/u><\/a><\/h4>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2428hg-a513bc13cdd16da3d0cdf23464eb591b\">\n.flex_column.av-2428hg-a513bc13cdd16da3d0cdf23464eb591b{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2428hg-a513bc13cdd16da3d0cdf23464eb591b av_one_half  avia-builder-el-26  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><div  class='avia-builder-widget-area clearfix  avia-builder-el-27  avia-builder-el-no-sibling'><div id=\"hal-plus-publications-11\" class=\"widget clearfix wphal-plus-publications\"><h3 class=\"widgettitle\">Recently published by partner IEMN<\/h3><ul class=\"widhal-ul\"><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-04209565v1\" target=\"_blank\" rel=\"noopener\"><i>Molecular Omics<\/i>, 2023, 19 (10), pp.810-822. <a target=\"_blank\" href=\"https:\/\/dx.doi.org\/10.1039\/D3MO00050H\" rel=\"noopener\">\u27e810.1039\/D3MO00050H\u27e9<\/a><\/a><\/li><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-04182831v1\" target=\"_blank\" rel=\"noopener\"><i>Optimizing Imaging and Dose-Response in Radiotherapies Workshop<\/i>, Canceropole Grand Ouest, Oct 2023, Erquy, France. 1 page<\/a><\/li><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-04095730v1\" target=\"_blank\" rel=\"noopener\"><i>Pharmaceutics<\/i>, 2023, 15 (4), pp.1215. <a target=\"_blank\" href=\"https:\/\/dx.doi.org\/10.3390\/pharmaceutics15041215\" rel=\"noopener\">\u27e810.3390\/pharmaceutics15041215\u27e9<\/a><\/a><\/li><\/ul><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-f7c1061df29de8cca6b42fcf455fe4a0\">\n.flex_column.av-av_one_half-f7c1061df29de8cca6b42fcf455fe4a0{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-f7c1061df29de8cca6b42fcf455fe4a0 av_one_half  avia-builder-el-28  el_after_av_one_half  el_before_av_one_full  flex_column_div av-zero-column-padding  column-top-margin'     ><div  class='avia-builder-widget-area clearfix  avia-builder-el-29  avia-builder-el-no-sibling'><div id=\"hal-plus-publications-26\" class=\"widget clearfix wphal-plus-publications\"><h3 class=\"widgettitle\">Recently published by partner IEMN<\/h3><ul class=\"widhal-ul\"><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-04209565v1\" target=\"_blank\" rel=\"noopener\">Generation of \u03b2-like cell subtypes from differentiated human induced pluripotent stem cells in 3D spheroids<\/a><\/li><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-04182831v1\" target=\"_blank\" rel=\"noopener\">Innovative nanobody-targeted nanoplatform delivering manganese contrast agents for MRI visualization of pancreatic islet beta cells<\/a><\/li><li class=\"widhal-li\"><a href=\"https:\/\/hal.science\/hal-04095730v1\" target=\"_blank\" rel=\"noopener\">Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes<\/a><\/li><\/ul><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_full-25347b0a799d5b9f7058434b2a9c3182\">\n.flex_column.av-av_one_full-25347b0a799d5b9f7058434b2a9c3182{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_full-25347b0a799d5b9f7058434b2a9c3182 av_one_full  avia-builder-el-30  el_after_av_one_half  avia-builder-el-last  first flex_column_div av-zero-column-padding  column-top-margin'     ><div  class='avia-button-wrap avia-button-center  avia-builder-el-31  avia-builder-el-no-sibling'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_button_big-fe6aa98ef82cac4a635729c01a4f1913\">\n#top #wrap_all .avia-button.av-av_button_big-fe6aa98ef82cac4a635729c01a4f1913:hover{\ncolor:white;\ntransition:all 0.4s ease-in-out;\n}\n<\/style>\n<a href='https:\/\/resana.numerique.gouv.fr\/public\/perimetre\/consulter\/1327149' class='avia-color-theme-color avia-font-color-theme-color avia-button avia-button-fullwidth av-av_button_big-fe6aa98ef82cac4a635729c01a4f1913 avia-icon_select-no avia-color-theme-color'   aria-label=\"Acces membres NANOMIC\"><span class='avia_iconbox_title' >Acces membres NANOMIC<\/span><span class='avia_button_background avia-button avia-button-fullwidth avia-color-theme-color'><\/span><\/a><\/div><\/div><\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":12,"featured_media":0,"parent":0,"menu_order":30,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-55124","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/55124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=55124"}],"version-history":[{"count":2,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/55124\/revisions"}],"predecessor-version":[{"id":73628,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/55124\/revisions\/73628"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=55124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}