{"id":40083,"date":"2020-04-08T14:53:12","date_gmt":"2020-04-08T12:53:12","guid":{"rendered":"https:\/\/www.iemn.fr\/?page_id=40083"},"modified":"2025-05-16T09:34:51","modified_gmt":"2025-05-16T07:34:51","slug":"ongoingstudies","status":"publish","type":"page","link":"https:\/\/www.iemn.fr\/en\/la-recherche\/les-groupes\/biomems\/ongoingstudies","title":{"rendered":"On going studies"},"content":{"rendered":"<div id='layer_slider_1'  class='avia-layerslider main_color avia-shadow  avia-builder-el-0  el_before_av_submenu  avia-builder-el-first  container_wrap sidebar_right'  style='height: 261px;'  ><div id=\"layerslider_43_dzfwqhbf1x8j\" data-ls-slug=\"homepageslider\" class=\"ls-wp-container fitvidsignore ls-selectable\" style=\"width:1140px;height:260px;margin:0 auto;margin-bottom: 0px;\"><div class=\"ls-slide\" data-ls=\"bgposition:50% 50%;duration:6000;transition2d:5;\"><img loading=\"lazy\" decoding=\"async\" width=\"2600\" height=\"270\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens.jpg\" class=\"ls-bg\" alt=\"\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens.jpg 2600w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens-300x31.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens-768x80.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens-1030x107.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens-1500x156.jpg 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2018\/10\/sliders_groupe_biomens-705x73.jpg 705w\" sizes=\"auto, (max-width: 2600px) 100vw, 2600px\" \/><ls-layer style=\"font-size:14px;text-align:left;font-style:normal;text-decoration:none;text-transform:none;font-weight:700;letter-spacing:0px;background-position:0% 0%;background-repeat:no-repeat;mix-blend-mode:normal;top:231px;left:0px;height:30px;width:320px;line-height:32px;color:#ffffff;border-radius:6px 6px 6px 6px;padding-left:50px;background-color:rgba(0, 0, 0, 0.57);\" class=\"ls-l ls-ib-icon ls-text-layer\" data-ls=\"minfontsize:0;minmobilefontsize:0;\"><i class=\"fa fa-user-circle\" style=\"color:#f2f2f2;margin-right:0.8em;font-size:1em;transform:translateY( -0.125em );\"><\/i>GROUPE DE RECHERCHE : BioMEMS<\/ls-layer><\/div><\/div><\/div>\n<div id='sub_menu1'  class='av-submenu-container av-jrqfadqy-ce2f2ab09b07c9cd48b0b2cdd423b7d9 footer_color  avia-builder-el-1  el_after_av_layerslider  el_before_av_heading  submenu-not-first container_wrap sidebar_right' style='z-index:301' ><div class='container av-menu-mobile-disabled av-submenu-pos-left'><ul id='av-custom-submenu-1' class='av-subnav-menu' role='menu'>\n<li class='menu-item av-rtfnbz-056deec7692d277d1153b80d988f410a menu-item-top-level menu-item-top-level-1' role='menuitem'><a href='https:\/\/www.iemn.fr\/en\/la-recherche\/les-groupes\/biomems'  ><span class='avia-bullet'><\/span><span class='avia-menu-text'>Introduction<\/span><\/a><\/li>\n<li class='menu-item av-150yk73-c57aa7653d5612615c65b80664eaf5fd menu-item-top-level menu-item-top-level-2' role='menuitem'><a href='https:\/\/www.iemn.fr\/en\/la-recherche\/les-groupes\/biomems\/members\/'  ><span class='avia-bullet'><\/span><span class='avia-menu-text'>Members<\/span><\/a><\/li>\n<li class='menu-item av-1aop3en-559a4f35fc91b2dfcf72c0e080935c76 menu-item-top-level menu-item-top-level-3' role='menuitem'><a href='https:\/\/www.iemn.fr\/en\/la-recherche\/les-groupes\/biomems\/ongoingstudies'  ><span class='avia-bullet'><\/span><span class='avia-menu-text'>On going studies<\/span><\/a><\/li>\n<\/ul><\/div><\/div><div id='after_submenu_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-40083'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ksnaz7-09867a5420a017d073aced600fce9a8e\">\n#top .av-special-heading.av-ksnaz7-09867a5420a017d073aced600fce9a8e{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-ksnaz7-09867a5420a017d073aced600fce9a8e .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-ksnaz7-09867a5420a017d073aced600fce9a8e .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-ksnaz7-09867a5420a017d073aced600fce9a8e av-special-heading-h2  avia-builder-el-2  el_after_av_submenu  el_before_av_textblock  avia-builder-el-first'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >BioMEMS Group On going studies<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-k8rc2orh-5f2be3b0665e580de50a447c243fc482'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/bandeau_biomems-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41716\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/bandeau_biomems-1.png\" alt=\"\" width=\"1600\" height=\"194\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/bandeau_biomems-1.png 825w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/bandeau_biomems-1-300x36.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/bandeau_biomems-1-768x93.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/bandeau_biomems-1-705x85.png 705w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><\/a><\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: -187px; top: -12.4063px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n<\/div><\/section>\n<div  class='flex_column av-1hx29cj-bec2dfdaa7e62b198c750b3e743059c6 av_one_full  avia-builder-el-4  el_after_av_textblock  el_before_av_one_full  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-lyehnw53-dd30d77196672c921d3feac92832f1c7'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.26.34.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-67948 size-thumbnail alignleft\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.26.34-80x80.png\" alt=\"\" width=\"80\" height=\"80\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.26.34-80x80.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.26.34-36x36.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.26.34-180x180.png 180w\" sizes=\"auto, (max-width: 80px) 100vw, 80px\" \/><\/a><\/p>\n<h1 style=\"text-align: center;\"><span style=\"text-decoration: underline;\">Axe 1 : Approches technologiques et m\u00e9thodologiques multi-\u00e9chelles pour une sant\u00e9 de pr\u00e9cision :<\/span><\/h1>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1ibpitv-945df4efbf6027736a00aaee49f8798f\">\n.flex_column.av-1ibpitv-945df4efbf6027736a00aaee49f8798f{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-1ibpitv-945df4efbf6027736a00aaee49f8798f av_one_full  avia-builder-el-6  el_after_av_one_full  el_before_av_one_full  first flex_column_div av-zero-column-padding  column-top-margin'     ><div  class='togglecontainer av-maqhaipm-77b92cd94d63a1b831cab33bcada72d0  avia-builder-el-7  avia-builder-el-no-sibling  toggle_close_all' >\n<section class='av_toggle_section av-14izktv-58c1a2204b91dedacd117407c6d6934d'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-1' data-fake-id='#toggle-id-1' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-1' data-slide-speed=\"200\" data-title=\"Development of alternative Organ-on-Chip (OoC) models\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Development of alternative Organ-on-Chip (OoC) models\" data-aria_expanded=\"Click to collapse: Development of alternative Organ-on-Chip (OoC) models\">Development of alternative Organ-on-Chip (OoC) models<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-1' aria-labelledby='toggle-toggle-id-1' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4><\/h4>\n<h4 style=\"text-align: center;\">A new Microfluidic platform to follow the extravasation process and collect extravasated cancer cells<\/h4>\n<hr \/>\n<p>To prevent metastatic recurrences, we need to understand the steps of metastases that occur during and after dissemination of tumor cells from the primary site and develop strategies to block these steps. Once arrested on the capillary beds of targeted organs, tumor cells have to extravasate through the endothelial wall and enter these organs. This extravasation step is crucial for the establishment of metastatic tumors.  One point that needs to be elucidated is the stemness characteristics of metastatic cancer cells.<br \/>\n<a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-41500 alignleft\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_9-300x125.png\" alt=\"\" width=\"415\" height=\"173\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_9-300x125.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_9.png 525w\" sizes=\"auto, (max-width: 415px) 100vw, 415px\" \/><\/a>The first hypothesis is that cancer cells need to be in a stem-ness state to be able to initiate extravasation and then generate metastasis. The other hypothesis is that cancer cells will only display stemness characteristics once extravasated in the appropriate microenvironment.<\/p>\n<p data-wp-editing=\"1\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41597 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\" alt=\"\" width=\"819\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><\/p>\n<p style=\"text-align: center;\"><em>\u00a0<\/em><\/p>\n<h4><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_10.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-41502 alignright\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_10-300x148.png\" alt=\"\" width=\"367\" height=\"181\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_10-300x148.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_10.png 496w\" sizes=\"auto, (max-width: 367px) 100vw, 367px\" \/><\/a>Devices and results ________________<\/h4>\n<p>We developed an original biomimetic platform which enable not only to follow in real-time the extravasation process but also to collect, for further analyses, extravasated cancer cells. We developed an original biomimetic microchip with a specific new design allowing to study and follow in real time the cancer cells and their interactions with the endothelium wall.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41597 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\" alt=\"\" width=\"819\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41702\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic.png\" alt=\"\" width=\"786\" height=\"243\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic.png 1051w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic-300x93.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic-1030x319.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic-768x237.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/images_new_microfluidic-705x218.png 705w\" sizes=\"auto, (max-width: 786px) 100vw, 786px\" \/><\/a>Our device enables to collect extravasated cancer cells through the bottom collecting chamber and compare them, in term of phenotype with those that were not able to extravasate.  We use time-lapse imaging in a biomimetic microfluidic device to study the metastatic potential of breast cancer cells focusing on CSCs\/non-CSCs.  This new original microfluidic microchip enables to study in real-time cancer cells and their interaction with the endothelium through a complex bifurcation network mimicking capillary bed.  The effect of the metastatic microenvironment is studied, through the modulation of the bottom collecting chamber. In this study, we developed a new microfluidic device in order to study tumor cell extravasation.<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-msg6j7-204892e2a8034f0dd421f11d3a628ff2\">\n.av_font_icon.av-msg6j7-204892e2a8034f0dd421f11d3a628ff2{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-msg6j7-204892e2a8034f0dd421f11d3a628ff2 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-msg6j7-204892e2a8034f0dd421f11d3a628ff2 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : anthony.treizebre <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-41597\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png\" alt=\"\" width=\"300\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<h5 style=\"text-align: center;\"><\/h5>\n<h5 style=\"text-align: center;\"><strong>Collaborations<\/strong><\/h5>\n<h5 style=\"text-align: center;\"><strong><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_new_microfluidic.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41699 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_new_microfluidic.png\" alt=\"\" width=\"500\" height=\"78\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_new_microfluidic.png 500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_new_microfluidic-300x47.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_new_microfluidic-495x78.png 495w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/a><br \/>\n<\/strong><\/h5>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqh4k9o-3cc32291d1e567d4131fd7f313cd922b'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-2' data-fake-id='#toggle-id-2' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-2' data-slide-speed=\"200\" data-title=\"Biosensors for studying and quantifying the infectious nature of parasites\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Biosensors for studying and quantifying the infectious nature of parasites\" data-aria_expanded=\"Click to collapse: Biosensors for studying and quantifying the infectious nature of parasites\">Biosensors for studying and quantifying the infectious nature of parasites<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-2' aria-labelledby='toggle-toggle-id-2' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4 style=\"text-align: center;\">Biosensors for studying and quantifying the infectious nature of parasites<\/h4>\n<hr \/>\n<div>\n<p class=\"paragraph\"><span class=\"eop\">Les r\u00e9centes \u00e9pid\u00e9mies de Covid-19 et de grippes aviaires ont mis en lumi\u00e8re les risque de transmission d\u2019agents pathog\u00e8nes de l\u2019animal \u00e0 l\u2019Homme (maladie dites \u00ab\u00a0zoonotiques\u00a0\u00bb). Ces crises sanitaires ont \u00e9galement mis en \u00e9vidence l\u2019importance de d\u00e9finir le plus t\u00f4t possible la capacit\u00e9 de diff\u00e9rents variants, ou souches, \u00e0 induire la maladie (notion de la virulence). <\/span><\/p>\n<\/div>\n<div>\n<p class=\"paragraph\"><span class=\"eop\">Une fois d\u00e9termin\u00e9e sa virulence, la gestion des risques li\u00e9s \u00e0 un agent infectieux passe par le d\u00e9ploiement de nouvelles strat\u00e9gies th\u00e9rapeutiques et la recherche de nouveaux m\u00e9dicaments.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"paragraph\"><span class=\"eop\">Dans ce contexte, les parasites unicellulaires appartenant au genre <i>Cryptosporidium<\/i> repr\u00e9sentent un d\u00e9fi particuli\u00e8rement complexe \u00e0 relever aussi bien pour les instances de sant\u00e9 public que pour les entreprises pharmaceutiques. En effet, malgr\u00e9 des d\u00e9cennies de recherche, il demeure toujours de vraies lacunes technologiques dans les mod\u00e8les de culture <i>in vitro<\/i> mis \u00e0 disposition des laboratoires de recherche. De m\u00eame l\u2019absence de m\u00e9dicaments permettant de traiter les patients immunod\u00e9prim\u00e9s contamin\u00e9s par ce parasite limite la capacit\u00e9 des praticiens hospitaliers ou des v\u00e9t\u00e9rinaires \u00e0 contr\u00f4ler les \u00e9pid\u00e9mies de Cryptosporidiose (la maladie induite par ce type de parasites).<\/span><\/p>\n<p style=\"font-weight: 400;\">Pour r\u00e9pondre \u00e0 ces grands enjeux de la m\u00e9decine animale et humaine, des strat\u00e9gies transdisciplinaires ont \u00e9t\u00e9 \u00e9labor\u00e9es. Elles combinent les savoirs faire issus de la micro\u00e9lectronique (construction d\u2019outils miniaturis\u00e9s en salle blanche), de la biologie et de l\u2019intelligence artificielle.<\/p>\n<p style=\"font-weight: 400;\">Grace \u00e0 cette approche transdisciplinaire, une plateforme de criblage de m\u00e9dicaments s\u2019appuyant sur des mesures \u00e9lectriques par spectroscopie d\u2019imp\u00e9dance a \u00e9t\u00e9 d\u00e9velopp\u00e9e. Cet outil a \u00e9t\u00e9 \u00e9labor\u00e9 dans le cadre d\u2019un projet Europ\u00e9en (port\u00e9 par l\u2019un membre de l\u2019\u00e9quipe BioMEMS). Ce dispositif d\u2019analyse est bas\u00e9 sur un r\u00e9seau de micro\u00e9lectrodes interdigit\u00e9es sur lesquelles des cellules humaines sont cultiv\u00e9es et infect\u00e9es par le parasite (<em>C. parvum<\/em>). Les donn\u00e9es obtenues ont montr\u00e9 que la r\u00e9ponse \u00e9lectrique enregistr\u00e9e \u00e9tait modifi\u00e9e en pr\u00e9sence de mol\u00e9cules inhibant le d\u00e9veloppement du parasite. Ces r\u00e9sultats repr\u00e9sentent la premi\u00e8re preuve de concept montrant l\u2019utilisation d\u2019une m\u00e9thode d\u2019analyse \u00e9lectrique non invasive utilis\u00e9e \u00e0 des fins de criblage de mol\u00e9cules \u00e0 vis\u00e9e th\u00e9rapeutique dirig\u00e9e contre un parasite. Cette strat\u00e9gie ouvre la voie \u00e0 l\u2019utilisation en routine de la spectroscopie d\u2019imp\u00e9dance dans le criblage de futurs m\u00e9dicaments de fa\u00e7on automatis\u00e9e et cin\u00e9tique.<\/p>\n<p style=\"font-weight: 400;\">Deux questions sont maintenant en cours d\u2019\u00e9tude sur cette plateforme imp\u00e9dim\u00e9trique\u00a0:<\/p>\n<ul>\n<li>Peut elle mesurer des variations de signature imp\u00e9dim\u00e9trique en fonction de souches de parasite pr\u00e9sentant des pouvoir infectieux diff\u00e9rents\u00a0?<\/li>\n<li>Peut elle \u00eatre appliqu\u00e9e \u00e0 d\u2019autres agents pathog\u00e8nes tels que des virus\u00a0?<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-41492 size-full alignleft\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_5.png\" alt=\"\" width=\"662\" height=\"359\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_5.png 662w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_5-300x163.png 300w\" sizes=\"auto, (max-width: 662px) 100vw, 662px\" \/><\/a><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-68018\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1-1030x713.jpg\" alt=\"\" width=\"572\" height=\"396\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1-1030x713.jpg 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1-300x208.jpg 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1-768x531.jpg 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1-18x12.jpg 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1-705x488.jpg 705w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Jerome-1.jpg 1298w\" sizes=\"auto, (max-width: 572px) 100vw, 572px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Droite: Conception g\u00e9n\u00e9rale du dispositif de criblage de m\u00e9dicaments. L\u2019image de droite montre des cellules HCT-8 dont le noyau est color\u00e9 au DAPI (points bleus) et qui se d\u00e9veloppent sur des micro\u00e9lectrodes interdigit\u00e9es. Cette couche cellulaire est infect\u00e9e par C. parvum (souche IOWA) marqu\u00e9 par des anticorps anti-Cryptosporidium marqu\u00e9s au Cy3 (points rouges). Gauche: Variation de la valeur d\u2019imp\u00e9dances en fonction du temps mesur\u00e9e sur des cellules Humaines (HCT-8) infect\u00e9es par des parasites. Les donn\u00e9es sont enregistr\u00e9es varient en fonction d\u2019une gamme de concentration d\u2019un compos\u00e9 pr\u00e9sentant une activit\u00e9 inhibitrice. En vert\u00a0: T\u00e9moin n\u00e9gatif comprenant les cellules seules non infect\u00e9es. En Rouge, t\u00e9moin positif comprenant des cellules infect\u00e9es avec des parasites en l\u2019absence de mol\u00e9cule inhibitrices. En Jaune, orange et violet, cellules infect\u00e9es avec l\u2019ajout une concentration finale de mol\u00e9cules inhibitrice respectivement de 100 \u00b5g\/mL, 400 \u00b5g\/mL et 600 \u00b5g\/mL. Les valeurs pr\u00e9sent\u00e9es correspondent \u00e0 la moyenne des r\u00e9sultats obtenus sur n exp\u00e9riences +\/- la d\u00e9viation standard.<\/p>\n<p><strong><span style=\"color: #f16728;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8\">\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/span>Contact : jerome.follet <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> yncrea.fr<\/strong><\/p>\n<p><strong><span style=\"color: #f16728;\">\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-8-256c0167ba3b015c6c6c0c38d3f77426\">\n.av_font_icon.av-mqde7m-1-8-256c0167ba3b015c6c6c0c38d3f77426{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-8-256c0167ba3b015c6c6c0c38d3f77426 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-8-256c0167ba3b015c6c6c0c38d3f77426 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/span>Contact : alexis.vlandas <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/strong><\/p>\n<h4>Publications ________________<\/h4>\n<ol>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-04569394v1\">Leni\u00e8re AC, Vlandas A, Follet J. Treating cryptosporidiosis: A review on drug discovery strategies. Int J Parasitol Drugs Drug Resist. 2024 Apr 20;25:100542. doi: 10.1016\/j.ijpddr.2024.100542. Epub ahead of print. PMID: 38669849; PMCID: PMC11066572.<\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-04079642v1\">Hoque S, Pinto P, Ribeiro CA, Canniere E, Daandels Y, Dellevoet M, Bourgeois A, Hammouma O, Hunter P, Gentekaki E, Kv\u00e1\u010d M, Follet J, Tsaousis AD. Follow-up investigation into Cryptosporidium prevalence and transmission in Western European dairy farms. Vet Parasitol. 2023 Jun;318:109920. doi: 10.1016\/j.vetpar.2023.109920. Epub 2023 Apr 1. PMID: 37030025.<\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-03501771v1\">Pinto P, Ribeiro CA, Hoque S, Hammouma O, Leruste H, D\u00e9trich\u00e9 S, Canniere E, Daandels Y, Dellevoet M, Roemen J, Barbier Bourgeois A, Kv\u00e1\u010d M, Follet J, Tsaousis AD. Cross-Border Investigations on the Prevalence and Transmission Dynamics of Cryptosporidium Species in Dairy Cattle Farms in Western Mainland Europe. Microorganisms. 2021 Nov 20;9(11):2394. doi: 10.3390\/microorganisms9112394. PMID: 34835519; PMCID: PMC8617893.<\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-04466299v1\">Baydoun M, Vanneste SB, Creusy C, Guyot K, Gantois N, Chabe M, Delaire B, Mouray A, Baydoun A, Forzy G, Chieux V, Gosset P, Senez V, Viscogliosi E, Follet J, Certad G. Three-dimensional (3D) culture of adult murine colon as an in vitro model of cryptosporidiosis: Proof of concept. Sci Rep. 2017 Dec 11;7(1):17288. doi: 10.1038\/s41598-017-17304-2. PMID: 29230047; PMCID: PMC5725449.<\/a><\/li>\n<li style=\"font-weight: 400;\">Dibao-Dina A, Follet J, Ibrahim M, Vlandas A, Senez V. Electrical impedance sensor for quantitative monitoring of infection processes on HCT-8 cells by the waterborne parasite Cryptosporidium. Biosens Bioelectron. 2015 Apr 15;66:69-76. doi: 10.1016\/j.bios.2014.11.009. Epub 2014 Nov 10. PMID: 25460884.<\/li>\n<\/ol>\n<h4>On going projects ___________<\/h4>\n<p style=\"font-weight: 400;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-68019 size-medium alignleft\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4-300x62.png\" alt=\"\" width=\"300\" height=\"62\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4-300x62.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4-768x160.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4-18x4.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4-705x147.png 705w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-4.png 803w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Projet Viamea, financ\u00e9 par le programme \u00ab\u00a0Stimule\u00a0\u00bb, r\u00e9gion Hauts de France<\/p>\n<p style=\"font-weight: 400;\">Projet Cryptostrain, financ\u00e9 par demi bourse de th\u00e8se r\u00e9gion Hauts de France et Junia<\/p>\n<p style=\"font-weight: 400;\">Projet Healthy Teeth, finance par le programme Interreg France Wallonie Flandres (FWVl)<\/p>\n<h5><\/h5>\n<h5><\/h5>\n<h5 style=\"text-align: center;\"><strong><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41597 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\" alt=\"\" width=\"819\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><br \/>\nCollaborations<\/strong><\/h5>\n<h5><strong> <a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-68021 size-full aligncenter\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5.png\" alt=\"\" width=\"1274\" height=\"185\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5.png 1274w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5-300x44.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5-1030x150.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5-768x112.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5-18x3.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-5-705x102.png 705w\" sizes=\"auto, (max-width: 1274px) 100vw, 1274px\" \/><\/a><\/strong><\/h5>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqh5zno-136cc7d46d8e647a4b836a5a2e607e65'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-3' data-fake-id='#toggle-id-3' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-3' data-slide-speed=\"200\" data-title=\"Innovative microsystems for the multi-physical characterisation of living cells\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Innovative microsystems for the multi-physical characterisation of living cells\" data-aria_expanded=\"Click to collapse: Innovative microsystems for the multi-physical characterisation of living cells\">Innovative microsystems for the multi-physical characterisation of living cells<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-3' aria-labelledby='toggle-toggle-id-3' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4 style=\"text-align: center;\">Distinguishing cancer cells based on their biophysical signatures<\/h4>\n<hr \/>\n<div><span lang=\"EN-US\">Single cell research is crucial for cancer studies, especially when combined with liquid biopsy techniques, as it allows for the detailed analysis of circulating tumor cells (CTCs), and immune cells from a simple blood sample. Unlike traditional biopsies, liquid biopsies are minimally invasive and can be performed repeatedly, providing real-time insights into tumor dynamics, heterogeneity, and the immune response. This approach enhances the development of personalized treatments, improves monitoring of treatment efficacy, and aids in early cancer detection, ultimately leading to better patient outcomes and survival rates.<\/span><\/div>\n<div>\n<hr \/>\n<p style=\"font-weight: 400;\">The BioMEMS team has been developing advance bioMEMS devices for cancer cell analysis in two axes:<\/p>\n<\/div>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-67840\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1.png\" alt=\"\" width=\"500\" height=\"350\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1.png 921w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1-300x210.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1-768x537.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1-18x12.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay1-705x493.png 705w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">The first one is studying the biophysical properties of cells, as they have profound significance in the development of diagnostic tools and therapeutic interventions for cancer. CTCs, in particular, offer valuable insights into disease progression and treatment efficacy. <\/span><span style=\"font-weight: 400;\">We have been engaged in developing a high-throughput method for integration into routine medical assessments, and a sensitive method for versatile analysis answering fundamental questions. These devices explore the biophysical attributes of cells to discern their metastatic potential.<\/span><\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n<hr \/>\n<div><span lang=\"EN-US\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-67841\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2.png\" alt=\"\" width=\"500\" height=\"285\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2.png 898w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2-300x171.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2-768x438.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2-18x10.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay2-705x402.png 705w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/a><\/span><\/div>\n<div><\/div>\n<div><span lang=\"EN-US\">The second axe focusses on cell interaction studies, as analyzing the interactions among cells provides insightful information on different pathological contexts, e.g., cancers, genetic diseases, immunological responses, and bacterial infections. We developed a practical method forming these pairs of single-cells providing high throughput and high spatiotemporal resolution with specific access to each cell type separately.<\/span><\/div>\n<div><\/div>\n<\/div>\n<p style=\"text-align: left;\"><em><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41597 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\" alt=\"\" width=\"819\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><\/em><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-7-265cbd28d88e62ef5d6182cdc41a283d\">\n.av_font_icon.av-mqde7m-1-7-265cbd28d88e62ef5d6182cdc41a283d{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-7-265cbd28d88e62ef5d6182cdc41a283d .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-7-265cbd28d88e62ef5d6182cdc41a283d avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : cagatay.tarhan <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> yncrea.fr<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h4>Publications ________________<\/h4>\n<p style=\"font-weight: 400;\">(i)<\/p>\n<ol>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-02105859v1\">Y. Tauran, M. Kumemura, M. C. Tarhan, G. Perret, F. Perret, L. Jalabert, D. Collard, H. Fujita and A.W. Coleman, \u201cDirect measurement of the mechanical properties of a chromatin analog and the epigenetic effects of para-sulphonato-calix[4]arene\u201c, Scientific Reports, 9, 5816, 2019.<\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-03185615v1\">Y. Takayama, G. Perret, M. Kumemura, M. Ataka, S. Meignan, S. L. Karsten, H. Fujita, D. Collard, C. Lagadec, M. C. Tarhan, Developing a MEMS Device with Built-in Microfluidics for Biophysical Single Cell Characterization. Micromachines, 9, 275, 2018.<\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-02105863v1\">Y. Tauran,* M. C. Tarhan,* L. Mollet,* J.B. Gerves, M. Kumemura, L. Jalabert, N. Lafitte, I. Byun, B.J. Kim, H. Fujita, D. Collard, F. Perret, K. Suwinska, C. Goutaudier and A.W. Coleman, \u201cElucidating the mechanism of the considerable mechanical stiffening of DNA induced by the couple Zn2+\/Calix[4]arene-1,3-Odiphosphorous acid\u201c, Scientific Reports, 8, 1226, 2018, (*: equal contribution).<\/a><\/li>\n<\/ol>\n<p style=\"font-weight: 400;\">(ii)<\/p>\n<ol>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-04318482v1\"> F. A. Shaik, C. Lewuillon, A. Guillemette, B. Ahmadian, C. Brinster, B. Quesnel, D. Collard, Y. Touil, L. Lemonnier and M. C. Tarhan, \u00ab\u00a0Pairing cells of different sizes in a microfluidic device for immunological synapse monitoring\u00a0\u00bb, Lab on a Chip, 22, 908-920, 2022. (HOT artciles of 2022)<\/a><\/li>\n<\/ol>\n<h4>On going projects ___________<\/h4>\n<p style=\"font-weight: 400;\">(i)<\/p>\n<ul>\n<li><em>High-throughput identification of circulating cancer cells using biophysical signature<\/em>, I-Site ULNE, 2018-2022.<\/li>\n<li><em>Modeling and classification of cancer cells using biophysical signatures<\/em>, Region HdF \/ I-Site (PhD student support), 2020-2023.<\/li>\n<li><em>Smart MEMS Instrumentation for Biophysical flow Cytometry with Statistical Learning<\/em>, ANR PRCE, 2022-2025.<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">(ii)<\/p>\n<ul>\n<li><em>Towards precision immunotherapies: Microfluidic single cell technology to unravel the PD-1\/PDL1 calcium signature in the immunological synapse<\/em>, Fondation ARC, 2019-2022.<\/li>\n<li><em>Role of calcium signaling in acute myeloid leukemia and the immunological synapse,<\/em> PLBIO, INCa, 2023-2027.<\/li>\n<\/ul>\n<h5><strong><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-67854\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3.png\" alt=\"\" width=\"803\" height=\"130\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3.png 1336w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3-300x49.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3-1030x167.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3-768x124.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3-18x3.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Cagatay-3-705x114.png 705w\" sizes=\"auto, (max-width: 803px) 100vw, 803px\" \/><\/a><\/strong><\/h5>\n<h5><\/h5>\n<h5><\/h5>\n<h5 style=\"text-align: center;\"><strong><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41597 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\" alt=\"\" width=\"819\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><br \/>\nCollaborations:<\/strong><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68067\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6-1030x297.png\" alt=\"\" width=\"699\" height=\"202\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6-1030x297.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6-300x87.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6-768x222.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6-18x5.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6-705x203.png 705w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-6.png 1255w\" sizes=\"auto, (max-width: 699px) 100vw, 699px\" \/><\/a><\/h5>\n<h5><strong>\u00a0<\/strong><\/h5>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqh8hyc-ec40dc77b31a8859cda02c93dc3630c1'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-4' data-fake-id='#toggle-id-4' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-4' data-slide-speed=\"200\" data-title=\"Development and understanding of innovative pharmacological approaches\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Development and understanding of innovative pharmacological approaches\" data-aria_expanded=\"Click to collapse: Development and understanding of innovative pharmacological approaches\">Development and understanding of innovative pharmacological approaches<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-4' aria-labelledby='toggle-toggle-id-4' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4><\/h4>\n<h4 style=\"text-align: center;\">High throughput opto-fluidic devices for cells treatment and therapies<\/h4>\n<hr \/>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-41494\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_6.png\" alt=\"\" width=\"534\" height=\"251\" \/><\/a>In diagnosis and therapy protocols, improving the efficiency of biological cell manipulations, like cell labelling or cancer immunotherapy, requires a controlled release of large molecular agents at high throughput. Several drawbacks characterize up to date techniques: cytotoxicity, low efficiency and throughput, specificity in drug or size or type of molecules. This project consists of developing a new high cell yield approach using gold nanoparticles mediated photoporation in a microfluidic chip, offering high throughput and low cytotoxicity drug delivery for adherent or circulating living cell. Instead of fixed plasmonic patches, we propose a new configuration with the use of advected AuNPs to allow flow photoporation. With a fully versatile setup, the spatial organization within both the biological cell and AuNP flows becomes a key point to avoid cytotoxicity due to cells\/AuNP contacts.<\/p>\n<p style=\"text-align: center;\"><em>\u00a0<\/em><\/p>\n<h4><strong><br \/>\n<\/strong>Devices and results _________<\/h4>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-41496 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_7.png\" alt=\"\" width=\"526\" height=\"205\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_7.png 526w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_7-300x117.png 300w\" sizes=\"auto, (max-width: 526px) 100vw, 526px\" \/><\/a>We have developed an original optofluidic devices based on a specific microfluidic design to finely control the relative distance between the flow containing the cells and the flow with gold nanoparticles. Additionally, to this improvement, tuning the distance between the two species gives us control over the mechanical stress caused by nanobubble collapse, and thus makes the optofluidic device compatible with stress sensitive cells.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-41498 alignright\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/image_8-300x279.png\" alt=\"\" width=\"341\" height=\"315\" \/><\/a>We worked through various protocols to establish a method to perform distant photoporation, that is, separating AuNPs from cells without pre-incubation in the prospect of retrieving AuNPs free photoporated samples. HeLa WT cells and AuNP suspension are injected in a microfluidic chip through separate inlets in such a way to control the distance between both distributions. Optical design was made to shape the laser beam properly and submit cells to a single pulse during their travel through the microchannel with respect to the flow rate. Permeabilization of cell membrane was monitored using FITC-dextran macromolecule incorporation via fluorescence microscopy.<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-6-05fee339e11cbd54dde622bcb2c724e7\">\n.av_font_icon.av-mqde7m-1-6-05fee339e11cbd54dde622bcb2c724e7{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-6-05fee339e11cbd54dde622bcb2c724e7 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-6-05fee339e11cbd54dde622bcb2c724e7 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : anthony.treizebre <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-5-65ae926bb1340f56177ef68ea9b2e0aa\">\n.av_font_icon.av-mqde7m-1-5-65ae926bb1340f56177ef68ea9b2e0aa{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-5-65ae926bb1340f56177ef68ea9b2e0aa .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-5-65ae926bb1340f56177ef68ea9b2e0aa avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : emmanuel.courtade <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<h4>Publications ________________<\/h4>\n<ol>\n<li>Treizebre, Q. Thommen, J. Pesez, H. Damart, L. Liegeois, E. Courtade, \u201cDevice and method for discriminating spermatozoa\u201d, Genes Diffusion\u00a0\/ Universit\u00e9 de Lille \/ CNRS. WO2018134281 (2018\/07\/26), INPI : FR3061910, 2018\/07\/20 (BOPI 2018-29).<\/li>\n<li><span style=\"font-weight: 400;\">A.Treizebre, Q. Thommen, J. Pesez, H. Damart, L. Liegeois, E. Courtade, \u00ab\u00a0Device and Method for selecting eukaryotic cells in a transportation channel by altering the eukariotic cells by means of electromagnetic radiation\u00a0\u00bb, Genes Diffusion \/ Universit\u00e9 de Lille \/ CNRS\u00a0, WO2016024061 (2016\/02\/18), INPI : FR3024738, 2016\/02\/12 (BOPI 2016-06).<\/span><\/li>\n<li>Braeckmans, A. Treizebre, R.Xiong, F.Anquez, Q.Thommen, E.Courtade, M.Layachi, \u00ab\u00a0Proc\u00e9d\u00e9 et dispositif pour fournir un \u00e9coulement fluidique\u00a0\u00bb, Universit\u00e9 de Gant, Universit\u00e9 de Lille, Num\u00e9ro de demande W02020221883, PCT\/EP2020062084, Date de publication 2020\/11\/05.<\/li>\n<li>\n<p style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-03996959v1\">Layachi, A. Treizebr\u00e9, L. Hay, D. Gilbert, J. Pesez, Q. D\u2019Acremont, K. Braeckmans, Q. Thommen and E. Courtade, Novel opto\u2011fluidic drug delivery system for efficient cellular transfection, J. Nanobiotechnology 21, 43 (2023)<\/a><\/p>\n<\/li>\n<\/ol>\n<h4><\/h4>\n<h4>On going project _________<\/h4>\n<p>ERC Nanobubble (Headed Pr. K. Breackmans, Univ Ghent)<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41597 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png\" alt=\"\" width=\"819\" height=\"1\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1.png 819w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-300x1.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-80x1.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-768x1.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-36x1.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-180x1.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-495x1.png 495w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-260x1.png 260w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-710x1.png 710w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/ligne-1-705x1.png 705w\" sizes=\"auto, (max-width: 819px) 100vw, 819px\" \/><\/a><\/p>\n<h5 style=\"text-align: center;\"><\/h5>\n<h5 style=\"text-align: center;\"><strong>Collaborations<\/strong><\/h5>\n<h5 style=\"text-align: center;\"><strong><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_high.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41691 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_high.png\" alt=\"\" width=\"360\" height=\"87\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_high.png 360w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_high-300x73.png 300w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/a><br \/>\n<\/strong><\/h5>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqh9d73-d916a4808de3e77f6d6d1425b3902904'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-5' data-fake-id='#toggle-id-5' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-5' data-slide-speed=\"200\" data-title=\"Innovative molecular approaches to analysing and manipulating living organisms\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Innovative molecular approaches to analysing and manipulating living organisms\" data-aria_expanded=\"Click to collapse: Innovative molecular approaches to analysing and manipulating living organisms\">Innovative molecular approaches to analysing and manipulating living organisms<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-5' aria-labelledby='toggle-toggle-id-5' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4 style=\"text-align: center;\">Innovative molecular approaches to analysing and manipulating living organisms<\/h4>\n<hr \/>\n<p style=\"font-weight: 400;\">La biologie synth\u00e9tique est un domaine en plein essor qui vise \u00e0 concevoir et construire des syst\u00e8mes biologiques nouveaux ou modifi\u00e9s pour des applications allant de la m\u00e9decine \u00e0 l\u2019agriculture. Un sous-domaine important de cette discipline est celui des cellules artificielles, qui cherchent \u00e0 imiter les fonctions des cellules naturelles de mani\u00e8re contr\u00f4l\u00e9e et pr\u00e9visible.<\/p>\n<p style=\"font-weight: 400;\">Notre th\u00e9matique de recherche explore la cr\u00e9ation de cellules artificielles\u00a0 capables de sentir et de r\u00e9agir \u00e0 leur environnement gr\u00e2ce \u00e0 des programmes mol\u00e9culaires. Ces syst\u00e8mes bio-inspir\u00e9s sont des v\u00e9sicules bilamellaires, fabriqu\u00e9es \u00e0 l\u2019aide de dispositifs microfluidiques d\u00e9di\u00e9s que nous d\u00e9veloppons au laboratoire. Elles se composent de trois \u00e9l\u00e9ments principaux : un capteur (membrane modifi\u00e9e r\u00e9pondant aux stimuli), un ordinateur (programme mol\u00e9culaire \u00e0 l\u2019int\u00e9rieur de la membrane) et un actionneur (diverses r\u00e9ponses biochimiques).<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68059 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1.png\" alt=\"\" width=\"947\" height=\"522\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1.png 947w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1-300x165.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1-768x423.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1-18x10.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Alex1-705x389.png 705w\" sizes=\"auto, (max-width: 947px) 100vw, 947px\" \/><\/a><\/p>\n<p><span style=\"font-weight: 400;\">La premi\u00e8re phase de ce projet consiste \u00e0 concevoir et construire de nouveaux dispositifs microfluidiques sp\u00e9cifiquement pour g\u00e9n\u00e9rer ces compartiments uniques. Ensuite, les robots seront test\u00e9s sur des t\u00e2ches simples, comme la lib\u00e9ration de mol\u00e9cules d\u2019int\u00e9r\u00eat d\u00e9clench\u00e9e par des signaux complexes ou la d\u00e9tection d\u2019analytes. La polyvalence et la capacit\u00e9 d\u2019adaptation de ces cellules artificielles les rendent adapt\u00e9es \u00e0 une large gamme d\u2019applications, y compris des diagnostics in vitro faciles \u00e0 utiliser et tr\u00e8s sensibles.<\/span><\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-4-3546d8f728ed83456eb9626e8b95b67c\">\n.av_font_icon.av-mqde7m-1-4-3546d8f728ed83456eb9626e8b95b67c{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-4-3546d8f728ed83456eb9626e8b95b67c .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-4-3546d8f728ed83456eb9626e8b95b67c avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : alexandre.baccouche <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqhahjh-becd43aec3bd58ae36140d4b374d6264'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-6' data-fake-id='#toggle-id-6' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-6' data-slide-speed=\"200\" data-title=\"Using AI for health\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Using AI for health\" data-aria_expanded=\"Click to collapse: Using AI for health\">Using AI for health<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-6' aria-labelledby='toggle-toggle-id-6' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4 style=\"text-align: center;\"><strong><span lang=\"EN-US\">Advancing Histopathological Image Analysis: AI-Driven Computer Vision for Diagnostic Classification and Treatment Response Prediction<\/span><\/strong><\/h4>\n<hr \/>\n<p style=\"text-align: left;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-67837 alignleft\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-1.png\" alt=\"\" width=\"168\" height=\"190\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-1.png 168w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-1-11x12.png 11w\" sizes=\"auto, (max-width: 168px) 100vw, 168px\" \/><\/a>Cancer represents a major public health challenge, requiring innovations to improve diagnosis and predict responses to treatment. Our projects use artificial intelligence to analyse data such as microscopic images and thus contribute to this fight.<\/p>\n<hr \/>\n<p style=\"text-align: left;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-67838 alignright\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-2-300x150.png\" alt=\"\" width=\"330\" height=\"165\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-2-300x150.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-2-18x9.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Feryal-2.png 704w\" sizes=\"auto, (max-width: 330px) 100vw, 330px\" \/><\/a>The main objective of this area of the team\u2019s activity is to develop and refine artificial intelligence (AI) models capable of diagnosing various types and subtypes of cancer based on histopathological data. We also aim to predict patients\u2019 life expectancy and their response to specific treatments.<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-3-f549126870fbed470edfecde6bc5259f\">\n.av_font_icon.av-mqde7m-1-3-f549126870fbed470edfecde6bc5259f{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-3-f549126870fbed470edfecde6bc5259f .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-3-f549126870fbed470edfecde6bc5259f avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : feryal.windal <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> junia.com<\/p>\n<hr \/>\n<h4>Publications ________________<\/h4>\n<p style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-04456283v1\">1- Guetarni, Bilel et al. \u201cA vision transformer-based framework for knowledge transfer from multi-modal to mono-modal lymphoma subtyping models.\u201d IEEE journal of biomedical and health informatics PP (2023)<\/a><\/p>\n<p style=\"font-weight: 400;\"><a href=\"https:\/\/hal.science\/hal-03559897v1\">2- Azzouz, Abdelhakim et al. \u201cDeep Learning-Based Classification of Pancreatic Adenocarcinoma from Fine Needle Aspiration\/Biopsy Microscopic Images.\u201d Proceedings of Sixth International Congress on Information and Communication Technology (2021)<\/a><\/p>\n<p style=\"font-weight: 400;\">3- Michael Selasi DZAMESI et al. \u00ab A convolution-assisted vision transformer for the classification of Pancreatic Ductal Adenocarcinoma \u00bb CCCIE 2024, Springer.<\/p>\n<hr \/>\n<h4>On going projects ___________<\/h4>\n<p style=\"font-weight: 400;\">ANR IA_Ingineering\u00a0 (2021-2024) https:\/\/anr.fr\/Project-ANR-20-THIA-0016<\/p>\n<p style=\"font-weight: 400;\">Protocole R\u00e9gion Ethics (2023-2024). Aucun lien existant<\/p>\n<p style=\"font-weight: 400;\">JUNIA (2020-2021) Fond interne www.junia.com\/fr\/<\/p>\n<p style=\"font-weight: 400;\">Eurasant\u00e9 (2020) (https:\/\/www.eurasante.com\/appel-a-projet\/innovation-prevention\/)<\/p>\n<hr \/>\n<h5 style=\"text-align: center;\"><strong>Collaborations<\/strong><\/h5>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-67839 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN.png\" alt=\"\" width=\"1185\" height=\"174\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN.png 1185w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-300x44.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-1030x151.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-768x113.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-18x3.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-705x104.png 705w\" sizes=\"auto, (max-width: 1185px) 100vw, 1185px\" \/><\/a><\/p>\n<hr \/>\n<\/div><\/div><\/div><\/section>\n<\/div><\/div>\n<div  class='flex_column av-11rdrbn-7da9c22f72f804f4cf622a85110c8ea4 av_one_full  avia-builder-el-16  el_after_av_one_full  el_before_av_one_full  first flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-lyehqe5e-98e04f0d0cd41a4817280b46ae5dddcf'   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-67951 size-thumbnail\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11-80x80.png\" alt=\"\" width=\"80\" height=\"80\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11-80x80.png 80w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11-300x300.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11-12x12.png 12w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11-36x36.png 36w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11-180x180.png 180w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-08-a-16.46.11.png 491w\" sizes=\"auto, (max-width: 80px) 100vw, 80px\" \/><\/a><\/p>\n<h1 style=\"text-align: center;\"><span style=\"text-decoration: underline;\">Axe 2 : Conception et caract\u00e9risation de mat\u00e9riaux innovants :<\/span><\/h1>\n<\/div><\/section><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2npvctv-e7bfa8361bcfeac380db11803ad4e54a\">\n.flex_column.av-2npvctv-e7bfa8361bcfeac380db11803ad4e54a{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2npvctv-e7bfa8361bcfeac380db11803ad4e54a av_one_full  avia-builder-el-18  el_after_av_one_full  avia-builder-el-last  first flex_column_div av-zero-column-padding  column-top-margin'     ><div  class='togglecontainer av-maqhgpy8-2d54ef8b832d6dde2092130fe9c04aca  avia-builder-el-19  avia-builder-el-no-sibling  toggle_close_all' >\n<section class='av_toggle_section av-maqhetz0-ce995c4be347a2865e14b7301ed44781'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-7' data-fake-id='#toggle-id-7' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-7' data-slide-speed=\"200\" data-title=\"Bio-based materials and microtechnologies for the bio-economy\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Bio-based materials and microtechnologies for the bio-economy\" data-aria_expanded=\"Click to collapse: Bio-based materials and microtechnologies for the bio-economy\">Bio-based materials and microtechnologies for the bio-economy<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-7' aria-labelledby='toggle-toggle-id-7' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4 style=\"text-align: center;\"><span lang=\"EN-US\">Biosourced Materials and Micro-Technology for the Bioeconomy<\/span><\/h4>\n<hr \/>\n<p><span style=\"text-decoration: underline;\"><strong>Context:<\/strong><\/span><\/p>\n<p style=\"font-weight: 400;\">The increase in fossil resource prices, the fact that they will not be indefinitely available, and the need to act for environmental preservation drive the search for alternative technologies to valorize biomass. Thus, our team is working on developing enzyme screening tools and sensors for biomass valorization. To do so we rely on advanced microfluidics devices produced in our cleanroom, optical or electrical sensors and novel molecular approaches.<\/p>\n<p style=\"font-weight: 400;\">Following a series of ANR projects and technological maturation funding from SATT Nord, a startup was created in 2019: Zymoptiq, which developed an innovative sensor and method enabling simpler, faster, and more reliable enzyme analysis.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68280\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7.png\" alt=\"\" width=\"632\" height=\"336\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7.png 1248w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7-300x160.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7-1030x548.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7-768x409.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7-18x10.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-7-705x375.png 705w\" sizes=\"auto, (max-width: 632px) 100vw, 632px\" \/><\/a><\/p>\n<div><span lang=\"EN-US\">Currently, we are involved in two ANR projects from the AAP 2021: MoBiDYC, based on the combination of a microfluidic system and molecular programming for the ultra-high throughput discovery of enzymes for biomass valorization (2021-2025), and BioLiDe, which aims to extract high-value-added chemicals through the biological depolymerization of lignin using enzyme sensors (high-throughput screening) (2021-2026) in partnership with the startup Zymoptiq and a pulp company: Fibre Excellence (Saint Gaudens).<\/span><\/div>\n<div><\/div>\n<div>\n<p style=\"text-align: left;\">This thematic is developed through a closed collaboration with Y. Coffinier (NCM group, IEMN).<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8\">\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : celine.vivien <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8\">\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : alexis.vlandas <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<\/div>\n<div><\/div>\n<div><span style=\"font-size: 18px; font-weight: 600;\">On going projects ___________<\/span><\/div>\n<div><\/div>\n<div><span lang=\"EN-US\">ANR MoBiDYC (2021-2025)<\/span><\/div>\n<div>ANR BioLiDe (2021-2026)<\/div>\n<div><\/div>\n<div style=\"text-align: center;\"><span style=\"font-size: large;\"><b>Collaborations<\/b><\/span><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68282 size-large\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8-1030x129.png\" alt=\"\" width=\"1030\" height=\"129\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8-1030x129.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8-300x38.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8-768x96.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8-18x2.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8-705x88.png 705w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/WEB-IEMN-8.png 1448w\" sizes=\"auto, (max-width: 1030px) 100vw, 1030px\" \/><\/a><\/div>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqhfhn1-024ec18e634761d346f007f38f5eb8d2'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-8' data-fake-id='#toggle-id-8' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-8' data-slide-speed=\"200\" data-title=\"Non wetting Slippery infused surfaces \" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Non wetting Slippery infused surfaces \" data-aria_expanded=\"Click to collapse: Non wetting Slippery infused surfaces \">Non wetting Slippery infused surfaces <span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-8' aria-labelledby='toggle-toggle-id-8' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4><\/h4>\n<h4 style=\"text-align: center;\">Non wetting Slippery infused surfaces<\/h4>\n<hr \/>\n<p><span style=\"text-decoration: underline;\"><strong>Context:<\/strong><\/span><\/p>\n<p>Developing surfaces that do not adhere to liquids has applications in a large number of day-to-day applications (vehicle windscreens, surfaces that do not adhere to molecules or viruses, anti-icing, etc.). These surfaces are generally called superhydrophobic and are obtained by multi-scale texturing (at micro and nano scales) but are sometimes not very resistant to impacts, vibrations, temperature variations or a wide range of liquids (such as alcohols). To overcome these limitations, we are working on textured surfaces that are impregnated with an inherent liquid (typically oil). The liquid then sees only a smooth surface of oil on which it can slide.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68179\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1.png\" alt=\"\" width=\"888\" height=\"176\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1.png 2566w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-300x59.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-1030x204.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-768x152.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-1536x304.png 1536w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-2048x405.png 2048w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-18x4.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-1500x297.png 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent-1-705x140.png 705w\" sizes=\"auto, (max-width: 888px) 100vw, 888px\" \/><\/a><\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Objective<\/strong><\/span>: Obtain stable oil infused non wetting surfaces inside textured surfaces from Nepenthes plant bioinspiration.<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Applications:<\/strong><\/span> Antibiofouling, anti icing, non wetting surfaces.<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Challenge:<\/strong><\/span> Good oil retention properties by playing with both surface texturation and chemistry. Adjusted in function of application field.<\/p>\n<p style=\"text-align: left;\"><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68180\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2.png\" alt=\"\" width=\"661\" height=\"218\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2.png 2805w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-300x99.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-1030x340.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-768x253.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-1536x507.png 1536w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-2048x675.png 2048w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-18x6.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-1500x495.png 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Vincent2-705x232.png 705w\" sizes=\"auto, (max-width: 661px) 100vw, 661px\" \/><\/a><\/p>\n<p>Need to realize large surface (up to 100 cm\u00b2) to authorize characterization out of the laboratory. Ex. Windscreen (transparency required), production line\u2026<\/p>\n<p style=\"text-align: left;\">This thematic is developed through a closed collaboration with Y. Coffinier (NBI group, IEMN).<\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8\">\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : vincent.thomy <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h4>Publications ________________<\/h4>\n<ol>\n<li>Antifouling biomimetic liquid-infused stainless steel: application to dairy industrial processing<br \/>\nZOUAGHI S., SIX T., BELLAYER S., MORADI S., HATZIKIRIAKOS S.G., DARGENT T., THOMY V., COFFINIER Y., ANDRE C., DELAPLACE G., JIMENEZ M., ACS Appl. Mater. Interfaces 9, 31 (2017) 26565-26573 doi: 10.1021\/acsami.7b06709<\/li>\n<li><a href=\"https:\/\/hal.science\/IEMN\/hal-03381692v1\">Manon Saget, Caroline Fran\u00e7olle Almeida, Vanessa Fierro, Alain Celzard, Guillaume Delaplace, et al.. A critical review on surface modifications mitigating dairy fouling. <i>Comprehensive Reviews in Food Science and Food Safety<\/i>, 2021, 20 (5), pp.4324 \u2013 4366.<\/a><\/li>\n<li><a href=\"https:\/\/hal.science\/IEMN\/hal-04215387v1\">Anne-Sophie Vaillard, Manon Saget, Flavie Braud, Marc Lippert, Laurent Keirsbulck, et al.. Highly stable fluorine-free slippery liquid infused surfaces. <i>Surfaces and Interfaces<\/i>, 2023, 42, Part A, pp.103296. <\/a><\/li>\n<\/ol>\n<h4>On going projects ___________<\/h4>\n<p><a href=\"https:\/\/anr-economics.univ-lille.fr\/concept.html\">ANR Economics (2018-2022)<\/a><\/p>\n<p>CNRS INSIS Polytic (2020)<\/p>\n<p>StartAIRR Saathaf (2021-2022)<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/en\/projet-anr-coolisse\/\">ANR COOLISSE (2023-2027)<\/a><\/p>\n<h5 style=\"text-align: center;\"><\/h5>\n<h5 style=\"text-align: center;\"><strong>Collaborations<\/strong><\/h5>\n<h5 style=\"text-align: center;\"><strong>\u00a0<\/strong><\/h5>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-maqhg6u5-51293f2c311d0edcc86bdf01fd087378'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-9' data-fake-id='#toggle-id-9' class='toggler  av-title-above'  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-9' data-slide-speed=\"200\" data-title=\"Smart textile for personal thermal management\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: Smart textile for personal thermal management\" data-aria_expanded=\"Click to collapse: Smart textile for personal thermal management\">Smart textile for personal thermal management<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-9' aria-labelledby='toggle-toggle-id-9' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color'  itemprop=\"text\" ><h4 style=\"text-align: center;\">Smart textile for personal thermal management<\/h4>\n<hr \/>\n<p style=\"font-weight: 400;\">Our research theme, in collaboration with the Physics team (Ephony), aims to bring additional thermal comfort to the wearer, by adding polymer membranes to traditional textiles, thereby influencing the way in which the garments retain the heat emitted by the body. The aim of these membranes is to modify the interaction between textile and IR emitted by human body , thus accentuating the sensation of \u00ab\u00a0warmth\u00a0\u00bb provided by the garment, or, providing a sensation of coolness compared with an untreated textile. In the long term, a dynamic changeover between the \u00ab\u00a0warm\u00a0\u00bb and \u00ab\u00a0cool\u00a0\u00bb states could be envisaged, depending on external conditions.<\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68054 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1.png\" alt=\"\" width=\"1816\" height=\"448\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1.png 1816w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-300x74.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-1030x254.png 1030w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-768x189.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-1536x379.png 1536w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-18x4.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-1500x370.png 1500w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele1-705x174.png 705w\" sizes=\"auto, (max-width: 1816px) 100vw, 1816px\" \/><\/a><\/p>\n<p style=\"font-weight: 400;\">Our work over the period has focused mainly on the development of micro-structured polymer membranes to improve the thermal comfort experienced by a person at rest, by playing on the interaction between the textile and the radiation emitted by the human body in the mid-infrared (MIR) range (5-15\u00b5m).<\/p>\n<p style=\"font-weight: 400;\">2 strategies are currently studied to achieve this microstructuring (which could also be combined): either the integration of submicrometer particles within a polymer, or its structuring as a photonic crystal on the medium-IR scale.<\/p>\n<p style=\"font-weight: 400;\">This technological development, initiated through the Interreg France-Wallonie-Vlaanderen PHOTONITEX project and continued by the ANR PRCE POCOMA, has not only enabled the development of a thermal model for these membranes, but also the production of laboratory-scale demonstrators which have enabled room temperatures to be reduced by 1 to 2\u00b0C, while maintaining the individual\u2019s thermal comfort.<\/p>\n<p><span style=\"font-weight: 400;\">At present, the main challenge of the POCOMA project is to create demonstrators compatible with the textile industry by developing appropriate techniques.<\/span><\/p>\n<p><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68055 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2.png\" alt=\"\" width=\"893\" height=\"308\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2.png 893w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2-300x103.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2-768x265.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2-18x6.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Michele2-705x243.png 705w\" sizes=\"auto, (max-width: 893px) 100vw, 893px\" \/><\/a><\/p>\n<p><span style=\"color: #f16728;\"><strong>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8\">\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8{\ncolor:#f16728;\nborder-color:#f16728;\n}\n.av_font_icon.av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 .av-icon-char{\nfont-size:25px;\nline-height:25px;\n}\n<\/style>\n<span  class='av_font_icon av-mqde7m-1-ec2c04f41b7420486817f2e799a043b8 avia_animate_when_visible av-icon-style- avia-icon-pos-left avia-icon-animate'><span class='av-icon-char' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><\/span><\/strong><\/span>Contact : Michele.carette <img loading=\"lazy\" decoding=\"async\" class=\"align=absbottom wp-image-73424\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png\" alt=\"\" width=\"14\" height=\"14\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir.png 24w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2035\/05\/arobase_noir-12x12.png 12w\" sizes=\"auto, (max-width: 14px) 100vw, 14px\" \/> univ-lille.fr<\/p>\n<h4><\/h4>\n<h4>Publications ________________<\/h4>\n<ol>\n<li><a href=\"https:\/\/hal.science\/hal-03630726\"><span class=\"author\">M. Boutghatin<\/span>, <span class=\"author\">Y. Pennec<\/span>, <span class=\"author\">B. Djafari-Rouhani<\/span>, <span class=\"author\">A. Akjouj<\/span>, <span class=\"author\">V. Gaucher<\/span>, <span class=\"author\">H. Gidik<\/span>, <span class=\"author\">S. Assaf<\/span>, <span class=\"author\">M. Carette<\/span>, <span class=\"author\">V. Thomy<\/span>, <span class=\"articleTitle\">Asymmetric Design for a High-Performance Indoor Radiative Heating Fabric<\/span>. <i>Adv. Mater. Technol.<\/i><span class=\"pubYear\">2022<\/span>, <span class=\"vol\">7<\/span>, 2101738. https:\/\/doi.org\/10.1002\/admt.202101738<\/a><\/li>\n<li><a href=\"https:\/\/hal.science\/hal-03142220\">Polymer photonic crystal membrane for thermo-regulating textile, Assaf S., Boutghatin M.,\u00a0 Pennec Y., Thomy V., Korovin, A., Treizebre A., Carette M., Akjouj A., Gidik, Djafari-Rouhani B., Scientific Report (2020, to be published)<\/a><\/li>\n<\/ol>\n<h4>On going projects ___________<\/h4>\n<p>This work was partially supported by :<\/p>\n<ul>\n<li>Damart industrial contract (2021)<\/li>\n<li>Interreg Phtonitex (2028-2022) : http:\/\/www.photonitex.eu\/<\/li>\n<li>ANR PRCE (IEMN): Pocoma (2022-2026) : IEMN, DSB, GEMTEX, Junia, FOTON : https:\/\/www.iemn.fr\/projet-anr-pocoma<\/li>\n<li>Phd Funding R\u00e9gion Hauts-de-France \u2013 Univ. Lille, collaboration Univ Mons (Be)<\/li>\n<\/ul>\n<h5><\/h5>\n<h4 style=\"text-align: center;\"><strong><br \/>\nCollaborations &amp; Sponsors<\/strong><\/h4>\n<h4 style=\"text-align: center;\"><strong><br \/>\n<\/strong><strong> <a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_smart_textile.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-41618 size-full\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_smart_textile.png\" alt=\"\" width=\"787\" height=\"142\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_smart_textile.png 787w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_smart_textile-300x54.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_smart_textile-768x139.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2020\/06\/logos_smart_textile-705x127.png 705w\" sizes=\"auto, (max-width: 787px) 100vw, 787px\" \/><\/a><a href=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-68064\" src=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15.png\" alt=\"\" width=\"800\" height=\"110\" srcset=\"https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15.png 962w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15-300x41.png 300w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15-768x105.png 768w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15-18x2.png 18w, https:\/\/www.iemn.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-09-a-17.09.15-705x97.png 705w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/a><br \/>\n<\/strong><\/h4>\n<h5 style=\"text-align: center;\"><\/h5>\n<\/div><\/div><\/div><\/section>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":25695,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-40083","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/40083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/comments?post=40083"}],"version-history":[{"count":3,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/40083\/revisions"}],"predecessor-version":[{"id":73440,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/40083\/revisions\/73440"}],"up":[{"embeddable":true,"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/pages\/25695"}],"wp:attachment":[{"href":"https:\/\/www.iemn.fr\/en\/wp-json\/wp\/v2\/media?parent=40083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}